Orientador: Rogério Lopes Vieites / Banca: Juliana Audi Giannoni / Banca: Regina Marta Evangelista / Banca: Claudia Rucco Penteado / Banca: Angela Vacaro de Souza / Resumo: As espécies do gênero Garcinia apresentam concentrações expressivas de compostos fenólicos com atividade hipolipidêmica, anti-obesidade, anti-inflamatória e antioxidante in vitro e em modelos animais. O objetivo deste estudo foi realizar análises físico-químicas e quantificar compostos fenólicos e atividade antioxidante das folhas e frutos da espécie Garcinia cochinchinensis Choisy, conhecida como mangostão amarelo, e analisar os efeitos do consumo das frutas e folhas sobre o perfil bioquímico, antropométrico e comportamental de ratos Wistar. Os frutos e as folhas do mangostão amarelo foram obtidos do pomar da Faculdade de Tecnologia de Pompéia/SP, sendo realizadas análises de pH, sólidos solúveis, acidez titulável e ratio na polpa fresca. No extrato seco dos frutos foram efetuadas análises qualitativas colorimétricas para fitoquímicos e análises quantitativas nos frutos e folhas frescas para carotenóides, antocianinas, compostos fenólicos totais, flavonoides, pigmentos clorofila A e B, e atividade antioxidante total. Os sucos dos frutos e das folhas foram administrados em ratos Wistar machos, que constituíram cinco grupos experimentais: controle (G1), que receberam água ad libitum, G2 e G3, tratados com suco da polpa em concentrações de 20% e 40%, respectivamente, e G4 e G5, tratados com suco das folhas, em 20% e 40%, respectivamente. Após 40 dias de experimento os animais submetidos as doses mais concentradas de sucos da polpa e folhas do fruto (G3 e G5), além do grupo cont... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The species of the genus Garcinia present expressive concentrations of phenolic compounds with hypolipidemic, anti-obesity, anti-inflammatory and antioxidant activity in vitro and in animal models. The aim of this study was to quantify phenolic compounds and antioxidant activity of leaves and fruits of the species Garcinia cochinchinensis Choisy, known as yellow mangosteen, and analyze the effects of the consumption of fruit and leaves on the biochemical and anthropometric profile of Wistar rats. The fruit and leaves of the mangosteen yellow were obtained from the orchard of the Faculty of Technology of Pompeia/SP. Analyzes of pH, soluble solids and titratable acidity were performed on the fresh fruit pulp. In the dry extract of the fruits were performed qualitative colorimetric analysis for phytochemicals and quantitative analysis in fruit and fresh leaves to carotenoids, anthocyanins, phenolics, flavonoids, pigments chlorophyll A and B, and antioxidant activity by the hijacking of the stable free radical DPPH (radical 2.2-diphenyl-1-picrilidrazil). The juices of fruits and leaves were administered in male Wistar rats, which were five experimental groups: control (G1), which received water ad libitum, G2 and G3, treated with 20% and 40% of the pulp, juice and G4 and G5, treated with 20% and 40% of juice from the leaves, respectively. After 40 days of experiment, the animals submitted to the more concentrated doses of pulp juices and leaves of the fruit (G3 and G5), besides the control group, were submitted to behavior analysis using the open field and cross maze models. On the 41st day of the experiment, the blood of animals was collected for biochemical analysis of glucose, liver enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT), total cholesterol, VLDL-c, LDL-c, HDL-c, triglycerides and ultra-sensitive C-reactive protein. It was evaluated also anthropometric profile, being ... / Doutor
| Identifer | oai:union.ndltd.org:UNESP/oai:www.athena.biblioteca.unesp.br:UEP01-000898222 |
| Date | January 2018 |
| Creators | Farinazzi Machado, Flávia Maria Vasques, 1976. |
| Contributors | Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Agronômicas (Campus de Botucatu). |
| Publisher | Botucatu, |
| Source Sets | Universidade Estadual Paulista |
| Language | Portuguese |
| Detected Language | English |
| Type | text |
| Format | 102 p. : |
| Relation | Sistema requerido: Adobe Acrobat Reader |
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