Purpose: The objective of this study was to examine the timing of the age and the magnitude of peak lean tissue mass accrual (peak lean tissue velocity, PLTV) as it relates to the age and magnitude of peak cross sectional area velocity (PCSAV) and section modulus velocity (PZV) of proximal femur in both males and females during adolescence. We hypothesized that the age of PLTV would precede the age of PCSAV and PZV and that there be a positive relationship between the magnitude of PLTV and both PCSAV and PZV in both genders. <p>Methods: 41 males and 42 females aged 8-18 years were selected from the Saskatchewan Pediatric Bone Mineral Accrual Study (1991-2005). Participants total body lean tissue mass was assessed annually for 6 consecutive years using DXA. Narrow neck, intertrochanteric and femoral shaft cross sectional areas (CSA) and section modulus (Z) were determined annually using the hip structural analysis (HSA) program. Participants were aligned by maturational age (years from peak height velocity). Lean tissue mass, CSA, and Z were converted into whole year velocities and the maturational age of peak tissue velocities was determined using a cubic spline curve fitting procedure. A 2x3 (gender x tissue) factorial MANOVA with repeated measures was used to test for differences between age of PLTV and both, the age of PCSAV and PZV between males and females. Multiple regression analyses were used to determine the relationship between PLTV and both PCSAV and PZV.<p>Results: There were no sex differences in the ages at which tissue peaks occurred when aligned by maturational age. There were significant differences between the age of PLTV and both PCSAV and PZV at the narrow neck (p=0.001) and femoral shaft (p=0.03), where the age of PLTV preceded both PCSAV and PZV when pooled by gender. There were no significant differences at the intertrochanteric site (p=0.814). PLTV was a significant predictor of the magnitude of both PCSAV and PZV at all sites (p<0.05). <p> Conclusions: These findings support the hypothesis that the age of PLTV precedes the age of PCSA and PZV at the proximal femur and provides further evidence to support the muscle-bone relationship, suggesting that lean tissue mass accrual influences bone strength development at proximal femur during pubertal growth.
| Identifer | oai:union.ndltd.org:USASK/oai:usask.ca:etd-08062008-112134 |
| Date | 14 August 2008 |
| Creators | Jackowski, Stefan A |
| Contributors | Kontulainen, Saija, Faulkner, Robert A., Farthing, Jonathan, Cooper, David |
| Publisher | University of Saskatchewan |
| Source Sets | University of Saskatchewan Library |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://library.usask.ca/theses/available/etd-08062008-112134/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to University of Saskatchewan or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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