Asthma is complex and heterogeneous condition characterised by airway inflammation, airway hyperresponsiveness, variable airflow obstruction and symptoms including cough, wheeze and breathlessness. Many of those with asthma fail to achieve optimal control and there is a need to identify novel therapeutic targets and improve the way we detect airway inflammation if the burden of asthma is to be reduced. Chapters 1-4 explore whether agonists for the transcription factor, Peroxisome proliferator-activated receptor gamma (PPAR-y) have a role in asthma. We performed a single centre randomised two parallel group, double blind placebo controlled trial over a 12 week period using pioglitazone to activate PPAR-y. This was followed by a series of mechanistic in vitro experiments investigating whether there was evidence of PPAR-y translocation in sputum cells and airway smooth muscle cells.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:665481 |
| Date | January 2014 |
| Creators | Anderson, John Ross |
| Publisher | University of Nottingham |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
Page generated in 0.0025 seconds