The pharmacodynamic effects of Risperidone on the vestibular system were assessed via dynamic computed posturography in 12 healthy subjects (6 male). Subjects were administered 2 mg, orally, of Risperidone and assessed on the NeuroCom® Balance Master© system under varying conditions. The vestibular response was deductively quantified by first assessing balance with a static force plate and eyes closed (Condition 2), and then assessed on a dynamic force plate with eyes closed (Condition 5). On average, Condition 2 scores were 24.46 points higher than Condition 5 scores (95% CI [20.973, 27.957]). A Pearson correlation between scores in Condition 2 and 5 showed a significant, moderate positive correlation (r = .487, p <.001). A trend analysis showed the effect of time, post-dose, on equilibrium score to be linear in nature (p < .001). In conclusion, some, but not all, of the subjects involved in the study experienced diminished vestibular control after administration of Risperidone; this may be due to phenotypic differences or learning effects.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/23759 |
| Date | 12 July 2017 |
| Creators | Caccaviello, John Charles |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
| Rights | Attribution 4.0 International, http://creativecommons.org/licenses/by/4.0/ |
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