by Tsu Yun-Huang Stephen. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1992. / Includes bibliographical references (leaves 87-95). / ACKNOWLEDGEMENT --- p.1 / ABSTRACT --- p.2 / INTRODUCTION --- p.4 / Chapter SECTION 1: --- LITERATURE REVIEW --- p.5 / Chapter 1.1 --- Sensory ending in mammalian skin --- p.7 / Chapter 1.2 --- The slowly adapting type I mechanoreceptor --- p.7 / Chapter 1.3 --- The slowly adapting type II mechanoreceptor --- p.8 / Chapter 1.4 --- The role of the Merkel cell --- p.12 / Chapter 1.5 --- Hair cells as an analogy --- p.13 / Chapter 1.6 --- Molecular mechanism of SAI mechanotransduction --- p.14 / Chapter 1.7 --- Calcium influx and transmitter release --- p.17 / Chapter 1.8 --- Calcium homeostasis --- p.17 / Chapter 1.9 --- Substances that affect Calcium influx --- p.18 / Chapter "a," --- Inorganic ions --- p.18 / Chapter "b," --- Neomycin --- p.20 / Chapter "c," --- Verapamil --- p.20 / Chapter "d," --- Bay K8644 --- p.21 / Chapter 1.10 --- Modulators of intracellular calcium stores --- p.21 / Chapter 1.11 --- Caffeine and cAMP --- p.22 / Chapter 1.12 --- The mitochondria and NaN3 --- p.23 / Chapter SECTION 2: --- METHODS --- p.24 / Chapter 2.1 --- The Nerve Skin In Vitro Preparation --- p.25 / Chapter 2.2 --- Synthetic Interstitual Fluid --- p.25 / Chapter 2.3 --- Localised superfusion --- p.26 / Chapter 2.4 --- Nerve Chamber Perfusion --- p.26 / Chapter 2.5 --- Mechanical Stimulation and Experiment Control --- p.29 / Chapter 2.6 --- Data analysis --- p.29 / Chapter SECTION 3: --- RESULTS --- p.32 / Chapter 3.1 --- Viability of the Preparation --- p.33 / Chapter 3.2 --- Effects of Neomycin --- p.38 / Chapter 3.3 --- Effects of Magnesium --- p.47 / Chapter 3.4 --- Effects of Verapamil --- p.52 / Chapter 3.5 --- Effects of Bay-K-8644 --- p.58 / Chapter 3.6 --- Effects of Caffeine --- p.62 / Chapter 3.7 --- Effects of NaN3 --- p.69 / Chapter SECTION 4. --- DISCUSSION AND CONCLUSION / Chapter 4.1 --- Reliability of data obtained from the present in vitro preparation --- p.75 / Chapter 4.2 --- Comparison of the role of calcium in SAI and SA II receptors --- p.76 / Chapter 4.3 --- Synaptic link between Merkel cell and afferent nerve fibre? --- p.83 / Chapter SECTION5. --- REFERENCES --- p.87
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_318920 |
| Date | January 1992 |
| Contributors | Tsu, Yun-Huang., Chinese University of Hong Kong Graduate School. Division of Basic Medical Sciences. |
| Publisher | Chinese University of Hong Kong |
| Source Sets | The Chinese University of Hong Kong |
| Language | English |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, 95 leaves : ill. ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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