Wang Ya-ping. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1994. / Includes bibliographical references (leaves 111-120). / CONTENT / ACKNOWLEDGMENT / ABSTRACT / Chapter Chapter 1. --- Introduction / Chapter Chapter 2. --- Review of relevant literature / Chapter 2.1 --- Mammary structure and embryology / Chapter 2.2 --- Pathology of breast cancer / Chapter 2.3 --- Risk factors in breast cancer / Chapter 2.4 --- Prognostic factors in breast cancer / Chapter 2.5 --- Treatment of breast cancer / Chapter 2.6 --- Breast cancer research by flow cytometry / Chapter 2.7 --- c-erbB-2 oncogene research in breast cancer / Chapter 2.8 --- Tables and figures of chapter2 / Chapter Chapter 3. --- Materials and methods / Chapter 3.1 --- Flow cytometry assay of breast cancer tissue / Chapter 3.1.1 --- Sample collection / Chapter 3.1.2 --- Sample preparation for flow cytometric assay / Chapter 3.1.3 --- DNA content assay by flow cytometry / Chapter 3.1.4 --- Solutions for flow cytometric analysis / Chapter 3.2 --- c-erbB-2 and EGF receptor protein detection by immunohistochemical methods / Chapter 3.2.1 --- Preparation of sections / Chapter 3.2.2 --- Methods of staining / Chapter 3.2.3 --- Methods of analysis / Chapter 3.2.4 --- Confirmation of expression of c-erbB-2 protein by immunoblotting method / Chapter 3.2.5 --- Solutions for immunohistochemical and immunoblotting methods / Chapter 3.3 --- Clinical data from 346 breast cancer patients and method of analysis / Chapter 3.4 --- Tables and figures of chapter3 / Chapter Chapter 4. --- Results / Chapter 4.1 --- Results of flow cytometric analysis / Chapter 4.1.1 --- Tumour characteristics of 94 breast cancer patients / Chapter 4.1.2 --- Survival analysis by results of flow cytometry / Chapter 4.2 --- Results of immunohistochemical assay of c-erbB-2 and EGFr / Chapter 4.2.1 --- C-erbB-2 and EGFr expression in breast cancer / Chapter 4.2.2 --- The distribution of c-erbB-2 and EGFr expression in breast cancer / Chapter 4.2.3 --- Analysis of clinical outcome by c-erbB-2 and EGFr expression / Chapter 4.3 --- Clinical data of 346 patients with breast cancer / Chapter 4.3.1 --- Patients' characteristics / Chapter 4.3.2 --- Analysis of clinical data and outcome / Chapter 4.3.3 --- Analysis of clinical outcome according to histopathological characteristics of breast tumour / Chapter 4.3.4 --- Types of operation and clinical outcome / Chapter 4.3.5 --- Postoperative adjuvant therapy and clinical outcome / Chapter 4.3.6 --- Results from statistical analysis by Cox-regression / Chapter 4.4 --- Tables figures of chapter4 / Chapter Chapter 5. --- Discussion and conclusion / Chapter 5.1 --- Flow cytometric analysis of paraffin-embedded breast cancer tissue / Chapter 5.1.1 --- Evaluation of DNA flow cytometric results / Chapter 5.1.2 --- Correlation between tumor DNA aneuploidy or cell subpopulation and clinical outcome / Chapter 5.1.3 --- Correlation between S-phase fraction of breast tumour and clinical outcome / Chapter 5.1.4 --- Observation of high proportion of DNA hypoaneuploidy in this study / Chapter 5.2 --- c-erbB-2 oncogene overexpression in breast cancer / Chapter 5.2.1 --- c-erbB-2 oncoprotein expression in other studies / Chapter 5.2.2 --- Correlation between c-erbB-2 oncoprotein expression status and breast cancer pathogenesis / Chapter 5.3 --- Evaluation of EGFr expression in breast cancer / Chapter 5.4 --- Analysis of clinical data / Chapter 5.4.1 --- Clinical characteristics of patients with breast cancer / Chapter 5.4.2 --- Clinical characteristics of breast cancer and clinical outcome / Chapter 5.4.3 --- Clinical outcome by types of postoperative treatment / Chapter 5.5 --- Prognostic factors / Chapter 5.5.1 --- Our observations in comparison to other studies / Chapter 5.5.2 --- Prognostic factors for clinical application / Chapter 5.6 --- Tables and figures of chapter5 / References:
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_320707 |
| Date | January 1994 |
| Contributors | Wang, Ya-ping., Chinese University of Hong Kong Graduate School. Division of Surgical Sciences. |
| Publisher | Chinese University of Hong Kong |
| Source Sets | The Chinese University of Hong Kong |
| Language | English |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, vii, 120 leaves : ill. ; 30 cm. |
| Coverage | Hong Kong |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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