The post-translational modification of histones and their interaction with transcription factors is essential to gene regulation. Furthermore, these targets would greatly benefit from probe molecules to fully elucidate their biological actions and to potentially lead to therapeutics. However, these protein-protein interactions have been considered difficult to inhibit and few high-quality chemical probes currently exist for the study of epigenetic biological systems in particular.
| Identifer | oai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/12269851 |
| Date | 04 June 2016 |
| Creators | McKeown, Michael Robert |
| Contributors | Bradner, James Elliott |
| Publisher | Harvard University |
| Source Sets | Harvard University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Rights | open |
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