To test the hypothesis that postprandial rises of plasma
glucose attenuate the motivation derived from positive
tastes, I analyzed the effects of intraperitoneal (ip)
injections of glucose on sham feeding, a preparation in
which food intake is motivated primarily by taste
sensations. IP glucose suppressed sham feeding, with
maximal suppressions approximating 42%, but only when
glucose was administered contiguous with oropharyngeal
stimulation. The food intake inhibition produced by ip
glucose interacted with palatability; smaller doses of
glucose were required to suppress less concentrated sucrose
solutions. Closing the gastric cannula increased the
potency with which ip glucose inhibited eating suggesting
synergy of postabsorptive glucose with other postgastric
satiety signals. The inhibition of eating produced by ip
glucose did not result from malaise. Thus, postabsorptive
rises of plasma glucose decrease the ability of taste cues
to drive ingestion and suggest that this phenomenon may
contribute to spontaneous meal termination. / Thesis / Master of Science (MSc)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/22644 |
| Date | 12 1900 |
| Creators | Bedard, Michel |
| Contributors | Weingarten, H.P, Psychology |
| Source Sets | McMaster University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
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