Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2011. / Studies have shown that oxidative stress (OS) is a major pathological risk factor in various
diseases, including type 2 diabetes mellitus (T2DM). Hyperglycemia independently is a
generator of free radicals, hence increases the level of OS in T2DM subjects. The oxidation
of LDL is suggested to play a significant role in the pathogenesis of macrovascular
complications observed in diabetic patients. In subjects with hyperglycemia or
normoglycemia we investigated the relationship between MDA-protein adducts, HNE-protein
adducts and auto-antibodies against oxLDL, and cardiovascular profile as measured by hs-
CRP.
From an epidemiological study that screened a high risk urban population for diabetes using
oral glucose tolerance test, 98 hyperglycaemie and 79 normoglycaemic individuals were
selected for this study. Enzyme linked immuno-sorbent-assay methods were used to
determine the levels of serum MDA-protein adducts, HNE-protein adducts or auto-antibodies
against oxLDL. High sensitive CRP was measured by nephelometry.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:cput/oai:localhost:20.500.11838/2241 |
| Date | January 2011 |
| Creators | Tjaronda, Timothy Ngatangwe |
| Contributors | Matsha, T., Erasmus, R. T., Esterhuyse, J., Cape Peninsula University of Technology. Faculty of Health and Wellness Sciences. Department of Biomedical Sciences. |
| Publisher | Cape Peninsula University of Technology |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Rights | http://creativecommons.org/licenses/by-nc-sa/3.0/za/ |
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