Thesis (MScEng)--Stellenbosch University, 2012. / ENGLISH ABSTRACT: The monitoring of patients in healthcare is of prime importance to ensure their
efficient treatment. The monitoring of blood oxygen saturation in tissues
affected by diseases or conditions that may negatively affect the function is a
field that has grown in importance in recent times.
This study involved the development and testing of a highly sensitive noninvasive
blood oxygen saturation device. The device can be used to continuously
monitor the condition of tissue affected by diseases which affect the blood flow
through the tissue, and the oxygen usage in tissue. The device’s system was
designed to specifically monitor occluded tissue which has low oxygen
saturations and low perfusion. With the use of the device, it is possible to
monitor the status of tissue affected by diseases such as meningococcemia and
diabetes mellitus or conditions such as the recovery after plastic surgery.
The study delved into all aspects involved in the development of a non-invasive
artificial pulse oximeter, including but not limited to that of a detailed device
design, signals analysis, animal in-vivo and laboratory in-vitro system design for
the calibration of the system as well as human clinical validation and testing
procedures. All these aspects were compared to determine the relative
accuracies of the different models.
Through testing it was shown that it is possible to non-invasively measure the
mixed oxygen saturation in occluded tissue. However, without accurate
validation techniques and methods of obtaining both arterial and venous blood
samples in occluded tissue the system could not be fully validated for
determining both the arterial and venous oxygen saturations in the human invivo
study.
Although the system was unable to accurately measure specifically the venous
oxygenation it was able to measure the mixed oxygen saturation. With further
research it would be possible to validate the system for measuring both the
arterial and venous oxygen saturations. / AFRIKAANSE OPSOMMING: Die monitering van pasiënte in gesondheidsorg is van uiterste belang om
doeltreffende behandeling te verseker. Die monitering van bloedsuurstofversadiging
in weefsels wat geaffekteer word deur siektes of toestande wat ’n
negatiewe impak kan hê op die funksie daarvan is ’n gebied wat aansienlike
groei getoon het in die onlangse verlede.
Die studie het die ontwikkeling en toetsing van ’n hoogs sensitiewe nieindringende
bloedsuurstofversadigingsensor ingesluit. Hierdie sensor kan
gebruik word om deurentyd die toestand van weefsel te monitor wat
geaffekteer word deur siektes wat bloedvloei deur weefsel affekteer sowel as
die suurstofgebruik in die weefsel. Die stelsel is ontwerp om spesifiek die
ingeslote weefsel wat lae suurstofversadiging en lae perfusie het, te monitor.
Deur gebruik te maak van die toestel is dit moontlik om die toestand van die
weefsel wat geaffekteer word deur siektes soos meningococcemia en diabetes
mellitus of toestande soos die herstel na plastiese sjirurgie te monitor.
Die studie het gekyk na alle aspekte wat betrokke is in die ontwikkeling van ’n
nie-indringende kunsmatige pols-oksimeter, insluitend maar nie beperk tot
gedetailleerde ontwerp nie, sein analise, dier in-vivo en laboratorium in-vitro
stelselontwerp vir die kalibrasie van die stelsel sowel as menslike kliniese
bekragtiging en toetsprosedures. Al hierdie aspekte is vergelyk om die relatiewe
akkuraatheid van die verskillende modelle te bepaal.
Die toetse het gewys dat dit moontlik is om nie-indringend die gemengde
suurstofversadiging in weefsel te bepaal. Sonder akkurate bekragtigingstegnieke
en metodes om beide arteriële en vene bloedmonsters te versamel in ingeslote
weefsel kan die stesel nie ten volle bekragtig word om beide arteriële- en
veneversadigings in menslike in-vivo studie te bepaal nie.
Hoewel die stelsel nie ’n akkurate meting van die aarsuurstof kon kry nie, is daar
wel ’n akkurate meting geneem van die gemengde suurstofversadiging.
Toekomstige navorsing kan lei tot die bekragtiging van die stelsel om beide
arteriële en slagaar suurstofversadigings te meet.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:sun/oai:scholar.sun.ac.za:10019.1/19947 |
| Date | 03 1900 |
| Creators | Cloete, Garth |
| Contributors | Scheffer, C., Stellenbosch University. Faculty of Engineering. Dept. of Mechanical & Mechatronic Engineering. |
| Publisher | Stellenbosch : Stellenbosch University |
| Source Sets | South African National ETD Portal |
| Language | en_ZA |
| Detected Language | Unknown |
| Type | Thesis |
| Format | 86 p. : ill. |
| Rights | Stellenbosch University |
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