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Antimicrobial activity and stability of medicinal plant extracts : effect of simulated gastrointestinal conditions

Thesis (MTech. degree in Pharmaceutical Sciences)--Tshwane University of Technology, 2008. / The aim of the study is to investigate whether the chemical composition and antimicrobial activity of orally administered medicinal plants are affected by in vitro dissolution and gastrointestinal absorption processes. Few in vitro screening assays for biological activities of plant extracts consider the effect of the gastrointestinal system. This is an important factor for the bioavailability of plant extracts intended to be administered via the oral route. In this study, crude water and methanol extracts of selected plants (green tea, 'buchu', thyme, sage and wild camphor) were prepared and exposed to simulated gastric fluid and simulated intestinal fluid during dissolution studies. The crude extracts and resulting simulated gastric fluid and simulated intestinal fluid products were screened for antimicrobial activity.
Date January 2008
CreatorsVermaak, Ilze.
ContributorsViljoen, A. M., Hamman, J. H.
Source SetsSouth African National ETD Portal
Detected LanguageEnglish
Rights© 2008 Tshwane University of Technology

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