Abstract:
Drug dosage forms contain many components in addition to the active
pharmaceutical ingredient(s) to assist in the manufacturing process as well as to optimise
drug delivery. Due to advances in drug delivery technology, excipients are currently
included in novel dosage forms to fulfil specific functions and in some cases they directly
or indirectly influence the extent and/or rate of drug release and absorption. Since plant
polysaccharides comply with many requirements expected of pharmaceutical excipients
such as non-toxicity, stability, availability and renewability they are extensively
investigated for use in the development of solid oral dosage forms. Furthermore,
polysaccharides with varying physicochemical properties can be extracted from plants at
relatively low cost and can be chemically modified to suit specific needs. As an example,
many polysaccharide-rich plant materials are successfully used as matrix formers in
modified release dosage forms. Some natural polysaccharides have even shown
environmental-responsive gelation characteristics with the potential to control drug release
according to specific therapeutic needs. This review discusses some of the most important
plant-derived polymeric compounds that are used or investigated as excipients in drug
delivery systems.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:tut/oai:encore.tut.ac.za:d1001726 |
| Date | 16 July 2009 |
| Creators | Beneke, CE, Viljoen, AM, Hamman, JH |
| Publisher | Molecules |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Text |
| Format | |
| Rights | Molecules |
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