Retinoblastoma Binding Protein 6 (RBBP6) is a 200 KDa protein shown to play a role in 3'-
polyadenylation of mRNA transcripts, as well as to function as an E3 ligase catalysing
ubiquitination of cancer-associated proteins. RBBP6 has been previously reported to localise to
nuclear speckles, which are thought to play a role in mRNA splicing, presumably as a result of
its RS domain, which is known to target mRNA splicing factors to nuclear speckles. However
recent studies in our laboratory have shown that isoform 3 of RBBP6, consisting mainly of the
DWNN domain, also localises to speckles in resting cells, but more strongly in cells subjected to
various stresses, suggesting that the DWNN domain may be the speckle-targeting domain. / Magister Scientiae - MSc (Biotechnology)
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/6200 |
| Date | January 2018 |
| Creators | Mlaza, Mihlali |
| Contributors | Pugh, David J.R. |
| Publisher | University of the Western Cape |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Rights | University of the Western Cape |
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