Surgical embryo transfer in rodents is a common procedure in today’s research
laboratory, although little is known of the effect analgesics may have on not only the
recipient female but also the embryos. Two perioperative analgesics, ketoprofen and
buprenorphine, were evaluated against a saline control in terms of number of pups born,
number of pups weaned, and whether or not a litter was born. Both a uterine approach
and an oviduct approach were evaluated. Post-surgical behavior was compared among
the three surgical animals in each group, and between the non-surgical analgesic control
and its surgical counterpart. Results indicated that ketoprofen and buprenorphine have
no effect on the number of pups born, weaned, or litters born when compared to a saline
control. Significant differences were found between the non-surgical analgesic control
and its surgical counterpart in two behavioral categories; once for ketoprofen (behavior)
and once for buprenorphine (physical condition). No other differences were found.
| Identifer | oai:union.ndltd.org:tamu.edu/oai:repository.tamu.edu:1969.1/ETD-TAMU-1140 |
| Date | 15 May 2009 |
| Creators | Burckhardt, Heather Ann |
| Contributors | Ihrig, Melanie M. |
| Source Sets | Texas A and M University |
| Language | en_US |
| Detected Language | English |
| Type | Book, Thesis, Electronic Thesis, text |
| Format | electronic, application/pdf, born digital |
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