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Fabrication of organic and inorganic nanoparticles using electrospray

A new fabrication process of organic and inorganic nanoparticles and cups by
electrospraying blended polymer-sol-gel solutions followed by calcination has been
investigated. Because of low viscosity and high surface tension of blended polymersol-
gel solutions, an electrostatically extruded continuous liquid jet from the spray
source became tiny droplets with diameter of less than 1µm in transit. They were
collected as dried formats at the counter electrode. These are then calcinated to
eliminate polymers as well as cross-link sol-gel material. Silica nanocups have been
fabricated using the above technique and the probable methods to control their morphology
by varying the ionic concentration have been investigated. Experiments with
biodegradable polymers, like Poly Lactic Acid (PLA) and polyvinylpyrrolidine (PVP)
to fabricate nanoparticles using the above technique, have also been carried out. The
potential use of such biodegradable particles in drug delivery has been demonstrated.
This method can encapsulate drug in the particles without the need of any stabilizer
which can cause unwanted effect on the drug. The effect of solvents, polymer
concentration and deposition distance on morphology and diameter of particles was
also investigated on PLA particles. This process is a simple and efficient approach
for producing nanocomposite cups that cannot be made by an aggregation method
and also nano/micro particles which may find their use in drug delivery and filtration
media. Finally, a new technique to sort the particles based on their dimensions is
demonstrated. Because of interactions between charged droplets and a non-linear electrostatic field, nanoparticles with different dimensions are deposited at different
locations. By using this principle, silica nanocups have been sorted into three groups
with mean diameters of 0.31 µm, 0.7 µm and 1.1µm and a standard deviation of 20%.

Identiferoai:union.ndltd.org:tamu.edu/oai:repository.tamu.edu:1969.1/ETD-TAMU-1290
Date15 May 2009
CreatorsDeotare, Parag Bhaskar
ContributorsKameoka, Jun
Source SetsTexas A and M University
Languageen_US
Detected LanguageEnglish
TypeBook, Thesis, Electronic Thesis, text
Formatelectronic, application/pdf, born digital

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