The effect of menthol on nicotine metabolism was examined in liver S9 fractions of four different species and in the in vivo mouse model. The purpose of this study was to investigate three parameters: (1) biotransformation of nicotine to cotinine in various species (human, mouse, rat and trout) using in vitro methods; (2) to determine if the addition of menthol with nicotine altered biotransformation of nicotine to cotinine; (3) and to assess similar parameters in an in vivo mouse model. The major findings of this study include: (1) mice appear to metabolize nicotine, over time, in a manner similar to humans; (2) menthol decreased cotinine production, over time, after a single dose in mice; and (3) menthol increased cotinine production, over time, after repeated doses, in mice.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc407773 |
| Date | 12 1900 |
| Creators | Pace, Wendy Lee |
| Contributors | Huggett, Duane B., Burleson, Mark, Golden, Teresa D. |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | Text |
| Rights | Public, Pace, Wendy Lee, Copyright, Copyright is held by the author, unless otherwise noted. All rights Reserved. |
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