Schizophrenia is a debilitating psychiatric condition affecting almost one percent of the US population. Typical antipsychotics (e.g., haloperidol) have been in use for several decades and are generally very effective in treating the emotional and cognitive effects of schizophrenia, but are used as the last line of treatment due to their severe extrapyramidal motor side effects under chronic exposure. The present study was conducted to investigate the role of sex in determining the oromotor side effects of typical antipsychotics via measuring different behavioral dimensions of male and female Sprague-Dawley rats licking sucrose after haloperidol treatment. The results showed a stronger sensitivity in female rats than male rats within total licking responses and inter-lick intervals. The present results suggest closer attention needs to be paid to the role that sexual hormones play in the motor slowing and behavior-reducing effects of antipsychotics.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc822780 |
| Date | 12 1900 |
| Creators | Shoemaker, Danton L. |
| Contributors | Pinkston, Jonathan, Toussaint, Karen A., Ward, Todd, Schlund, Michael |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | iv, 23 pages : illustrations (some color), Text |
| Rights | Public, Shoemaker, Danton L., Copyright, Copyright is held by the author, unless otherwise noted. All rights Reserved. |
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