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Background: Postpartum Depression (PPD) affects up to one in five mothers. While psychotherapy can effectively reduce symptoms of PPD, it is unclear how PPD treatment affects maternal psychophysiology. Determining physiological changes in response to cognitive behavioural therapy (CBT) could provide insights into the mechanisms underlying effective treatment and/or help predict treatment outcomes. This study examined if treating PPD with CBT led to changes in frontal cortical activity and heart rate variability, two markers of maternal emotion regulatory capacity. Methods: Community-dwelling mothers with PPD (Edinburgh Postnatal Depression Scores ≥10) were randomized to receive nine weeks of group CBT delivered by recovered peers (i.e., those who had previously recovered from PPD) (n=26) or be put on a waitlist to receive the intervention nine weeks later (n=24). Electroencephalographic (frontal alpha asymmetry), electrocardiographic (heart rate variability), and clinical (depression, anxiety) data were collected at baseline and nine weeks later. Results: Participants in both the immediate treatment and waitlist control groups reported moderate levels of depression and anxiety at baseline. After treatment, mothers in the treatment group showed greater improvements in depression (p<0.01, Cohen d=1.22), and anxiety (p<0.005, Cohen d = 1.48), and high-frequency heart rate variability (p<0.05, Cohen d=0.70), but not frontal alpha asymmetry, compared to the waitlist control group. Conclusion: Group CBT for PPD can improve symptoms of depression and anxiety and parasympathetic nervous system function. Future research should attempt to replicate and extend these findings using larger samples, additional biomarkers, and longer periods of follow up. Examining how evidence-based treatments for PPD affect maternal psychophysiology can improve our understanding and potentially predict treatment effects. / Thesis / Master of Science (MSc) / Postpartum depression affects up to one in five mothers in the first year after delivery. When treated promptly with talking therapies (i.e., psychotherapy) such as cognitive behavioural therapy (CBT), many experience significant improvements in their symptoms. However, the changes occurring in the brain and the remainder of the nervous system occurring in response to psychotherapy is not well known. It is important that this is understood so that we can develop more effective treatments and better predict who will respond to different types of treatments. In particular, the role of the frontal lobe of the brain, and the body’s parasympathetic system is poorly understood in the context of PPD. This thesis aimed to examine the impact of CBT on women’s frontal lobe functioning using a measure called frontal alpha asymmetry (FAA) measured via electroencephalography (EEG), and parasympathetic nervous system-based heart rate variability (HRV) using electrocardiography (ECG). In this study, we compared mothers with PPD treated with CBT to those who did not receive this treatment. We found that HRV responded in mothers who received CBT compared to women who were in the control group. No significant changes were found for FAA after treatment. These results suggest that HRV may be explored further as a valid treatment outcome for CBT when provided to women with PPD.

Stress is a global health issue and effective stress management techniques are much needed. Mindfulness meditation in the form of mindfulness-based interventions have been shown to be effective interventions for self-reported stress reduction. However, the effects of mindfulness meditation on the objective physiological markers of stress are less clear. Heart rate variability, the variation in time between each consecutive heartbeat has been shown to be such an objective physiological marker of stress. The aim of this systematic review was to investigate how mindfulness-based interventions affect heart rate variability to better understand the utility of mindfulness meditation as a stress management technique. A literature search was conducted on March 8th, 2022, with the databases Web of Science, Scopus, and MEDLINE EBSCO to identify randomized controlled trials that examined the effects of mindfulness-based interventions on heart rate variability. A total of 10 studies met the inclusion criteria with a total of 970 participants. The results from the systematic review were mixed and indicate inconsistencies across the literature. Thus, there are uncertainties on how mindfulness-based interventions affect heart rate variability. Although the systematic review was limited by a small sample of studies, it highlights that further research on how mindfulness-based interventions affect heart rate variability is needed to better understand the utility of mindfulness meditation as a stress management technique.

The Wim Hof Method (WHM) is a contemporary combination of techniques including a breathing exercise, mindset and cold exposure. Interest in the method has blossomed in recent years as scientific studies has presented promising results on the methods impact on the autonomic nervous system (ANS) as well as the immune system. However, although biological factors have been demonstrated as a result of the method, psychological measures are lacking. In this study Subjective Well Being (SWB) was measured which refers to psychological attributes such as happiness, fulfilment and enrichment. As a biological marker Heart Rate Variability (HRV) was measured as it is theorised to be an indirect measure of the ANS which in turn often have been associated to reflect mental health. Measures of SWB and HRV were assessed pre- and post-intervention. Thirty-two participants met the inclusion criteria and were randomised into an intervention group and a control group. The intervention group was asked to do 10 days of WHM home practice after an initial introductory training. Meanwhile the control group were asked to live life as usual. Twenty-six participants completed the post assessments, and the collected data were analysed across time. It was found that participants in the intervention group reported a significant decrease in negative affect from pre-intervention to post-intervention in comparison to those in the control group. The present study adds to the existing research on the WHM by assessing new measures that reflect psychological well-being, namely SWB and HRV.

The value of heart rate variability (HRV) in the fields of health, disease, and exercise science has been established through numerous investigations. The typical mobile-based HRV device simply records interbeat intervals, without differentiation between noise or arrythmia as can be done with an electrocardiogram (ECG). The intent of this report is to validate a new single channel ECG device, the Movesense Medical sensor, against a conventional 12 channel ECG. A heterogeneous group of 21 participants performed an incremental cycling ramp to failure with measurements of HRV, before (PRE), during (EX), and after (POST). Results showed excellent correlations between devices for linear indexes with Pearson’s r between 0.98 to 1.0 for meanRR, SDNN, RMSSD, and 0.95 to 0.97 for the non-linear index DFA a1 during PRE, EX, and POST. There was no significant difference in device specific meanRR during PRE and POST. Bland–Altman analysis showed high agreement between devices (PRE and POST: meanRR bias of 0.0 and 0.4 ms, LOA of 1.9 to −1.8 ms and 2.3 to −1.5; EX: meanRR bias of 11.2 to 6.0 ms; LOA of 29.8 to −7.4 ms during low intensity exercise and 8.5 to 3.5 ms during high intensity exercise). The Movesense Medical device can be used in lieu of a reference ECG for the calculation of HRV with the potential to differentiate noise from atrial fibrillation and represents a significant advance in both a HR and HRV recording device in a chest belt form factor for lab-based or remote field-application.

京都大学 / 新制・課程博士 / 博士(情報学) / 甲第24742号 / 情博第830号 / 新制||情||139(附属図書館) / 京都大学大学院情報学研究科数理工学専攻 / (主査)教授 梅野 健, 教授 太田 快人, 准教授 辻本 諭 / 学位規則第4条第1項該当 / Doctor of Informatics / Kyoto University / DFAM

Stress is an ongoing and increasing problem at a societal and individual level. This systematic review aims to evaluate which effects breathwork has on stress in a healthy population. A literature search was done on Scopus, and Web of Science for peer-reviewed, published, and original research. In the search process, it was decided to include psychological and physiological assessments due to the narrow topic. Threestudies met the inclusion criteria and were included in this review. The outcome measurements included were heart-rate variability (HRV) which measures the activity in the autonomic nervous system (ANS) and salivary cortisol to measure cortisol as a biomarker of psychological stress, as well as the questionnaires PSS, PANAS, and STAI. There are many different breathwork techniques, in this review the focus is oncontrolled, slow deep breathing techniques e.g. diaphragmatic breathing, resonance breathing, and cyclic sighing. All three studies showed significant improvement in stress in the breathing groups. These findings suggest that breathwork can be valuable in reducing stress in healthy individuals. Furthermore, more research is needed before conclusions on the general population can be drawn.

Introduction: Guillain-Barré syndrome (GBS) is a neurological disease caused by an autoimmune attack on the peripheral nerves. The main symptoms are loss of motor and sensory skills in the upper and lower extremities. Autonomic dysfunction also occurs.Aim: To identify which parameters in neurography examination that are showing pathology at three different stages from the onset of symptoms. To practically perform and evaluate different electrode placements at RR-intervals.Materials and methods: The first part of this study was a retrospective study with results from 58 patients which were diagnosed with GBS in 2010-2020 at the University Hospital in Uppsala. The second part of this study included measurement of the heart rate variation with RR-intervals at different electrode placement in ten healthy volunteers. Results: In part 1 of the project, there were no significant differences between the groups at distal latency in the ulnar nerve, F-latency in the tibial nerve and in the conduction velocity in the sural nerve. However, there were significant differences in the amplitude of the radial nerve. In part 2 of the project, there were significant differences between the electrode placements, and most artifacts were found with electrodes placed on the shoulders.Conclusion: Examination with neurography and RR-intervals plays an important role in the diagnosis of GBS. As the amplitude in the radial nerve was the only one that showed significant differences between the groups, the nerve is recommended to be examined bilaterally. With a high presence of artifacts in RR-intervals with electrodes placed on the shoulders and wrists, placement on the chest is to be recommended.