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At present chemistry is undergoing an interesting change from the traditional preparation and investigation of single molecules to the construction and use of more complex functionalized architectures. Especially the better understanding of biological processes and the demand to create new materials with specific properties lead to a development of novel nanostructured assemblies that are held together by reversible weak interactions, that include coordination and hydrogen bonds, van der Waals forces as well as p-p and electrostatic interactions. Based on the smart use of Nature’s principles of molecular recognition and self-assembly, the supramolecular chemistry is now one of the pillars within the framework of nanotechnology. This contribution gives an overview on the basic concepts of supramolecular chemistry, the latter’s connections with biological systems and foreseeable applications. / Die Chemie erfährt gegenwärtig einen interessanten Übergang von der traditionellen Betrachtung der Einzelmoleküle hin zu großen komplexen Funktionseinheiten. Besonders das wachsende Verständnis biologischer Prozesse als auch die steigenden Forderungen nach neuen Werkstoffen mit einem spezifischen Eigenschaftsprofil führten zur gezielten Konstruktion definierter Baueinheiten auf der Nanometerskala. Dabei werden in intelligenter Weise reversible Bindungsprozesse auf Basis schwacher nichtkovalenter Wechselwirkungen, wie koordinative und Wasserstoffbrückenbindungen, Van-der-Waals- Kräfte sowie p−p- und elektrostatische Wechselwirkungen, genutzt. Aufbauend auf den natürlichen Prinzipien der molekularen Erkennung und Selbstorganisation ist die supramolekulare Chemie heute eine der Säulen in der Entwicklung der Nanotechnologie. Im Beitrag wird ein Überblick über wesentliche Aspekte der supramolekularen Chemie, ihre Anknüpfung an biologische Prinzipien und ausgewählte Nutzungsmöglichkeiten gegeben.

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<p dir="ltr">Methods of protein engineering and mutation to achieve selective and designed enzymatic function are often challenged by issues with foldamer stability. Molecular nanocages present an exciting new opportunity for biomimetic-defined cavities capable of biomolecule recognition and catalysis. While many different types of molecular cages exist, covalent organic molecular cages offer great flexibility and control over the design of the cage. Furthermore, the covalent linkages provide a robust framework resistant to degradation and stable in many chemical environments. Lastly, covalent organic cages may be designed for the precise placement of functional groups, including group placement inside the cage cavity for molecular recognition and binding. I report our recent advances in developing new synthetic methods for robust organic molecular cages with well-defined cavities and tunable functions for artificial enzyme catalysis and recognition. The basic design philosophy for such protein-mimetic structures will be introduced for the scalable synthesis of these macromolecules. Herein, we report two approaches to a [8+12] triazine-linked organic cage and a similar [8+12] triazine and boroxine-linked cage. While our first approach attempts a kinetically controlled tethered cage formation, our second method relies on the principles of dynamic covalent chemistry in the thermodynamically controlled self-assembly of the final cage structure.</p>

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