No description available.

No description available.

The principle of the combined reversed-phase chromatographic electrochemical detection assay of the major serum thyroid hormones is demonstrated. The separation of 3,3',5-triiodothyronine (T(,3)), 3,3',5'-triiodothyronine (rT(,3)) and 3,5,3',5'-tetraiodothyronine (T(,4)) has been studied as a function of solvent strength, pH, temperature and ionic strength. Detection was carried out using a thin-layer electrochemical detection cell set at 1.500 V containing a new material, low temperature isotropic carbon, as a working electrode. This material was evaluated against carbon paste and using it, subnanogram detection limits were noted for the above analytes under defined conditions. Investigation of the feasibility of this analysis applied to 1.0 mL serum samples was carried out using a combined solvent extraction-cation exchange resin clean-up approach. The data indicate that under the defined conditions, elevated total T(,3) levels can be discerned and total T(,4) levels quantitated demonstrating the potential utility of this approach in screening thyrometabolic status.

This work involves numerical integration as well as mathematical integration techniques in computing the bivariate and trivariate normal probabilities. The probabilities have been computed and tabulated for desired ranges of the non-negative values of the random variables, and for some specific values of correlation coefficients, taking the size of the tables into consideration. Formulas, however, also been given to derive the probabilities for negative values of the random variables.Computer programs have also been developed and included to compute the probabilities so as to produce the above mentioned probability tables. These computer programs were run on DECSYSTEM-10.

Using data from Hedge Fund Research, Inc. (HFR), this study adapts and expands on existing methods in survival analysis in an attempt to investigate whether hedge funds mortality can be predicted on the basis of certain hedge funds characteristics. The main idea is to determine the characteristics which contribute the most to the survival and failure probabilities of hedge funds and interpret them. We establish hazard models with time-independent covariates, as well as time-varying covariates to interpret the selected hedge funds characteristics. Our results show that size, age, performance, strategy, annual audit, fund offshore and fund denomination are the characteristics that best explain hedge fund failure. We find that 1% increase in performance decreases the hazard by 3.3%, the small size and the less than 5 years old hedge funds are the most likely to die and the event-driven strategy is the best to use as compare to others. The risk of death is 0.668 times lower for funds who indicated that an annual audit is performed as compared to the funds who did not indicated that an annual audit is performed. The risk of death for the offshore hedge funds is 1.059 times higher than the non-offshore hedge funds.

No description available.

Bibliography: leaves 220-224. / 224 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Statistics, 1997?

This thesis considers location and scale parameter modelling of the heteroscedastic t-distribution. This new distribution is an extension of the heteroscedastic Gaussian and provides robust analysis in the presence of outliers as well accommodates possible heteroscedasticity by flexibly modelling the scale parameter using covariates existing in the data. To motivate components of work in this thesis the Gaussian linear mixed model is reviewed. The mixed model equations are derived for the location fixed and random effects and this model is then used to introduce Restricted Maximum Likelihood ( REML ). From this an algorithmic scheme to estimate the scale parameters is developed. A review of location and scale parameter modelling of the heteroscedastic Gaussian distribution is presented. In this thesis, the scale parameters are a restricted to be a function of covariates existing in the data. Maximum Likelihood ( ML ) and REML estimation of the location and scale parameters is derived as well as an efficient computational algorithm and software are presented. The Gaussian model is then extended by considering the heteroscedastic t distribution. Initially, the heteroscedastic t is restricted to known degrees of freedom. Scoring equations for the location and scale parameters are derived and their intimate connection to the prediction of the random scale effects is discussed. Tools for detecting and testing heteroscedasticity are also derived and a computational algorithm is presented. A mini software package " hett " using this algorithm is also discussed. To derive a REML equivalent for the heteroscedastic t asymptotic likelihood theory is discussed. In this thesis an integral approximation, the Laplace approximation, is presented and two examples, with the inclusion of ML for the heteroscedastic t, are discussed. A new approximate integral technique called Partial Laplace is also discussed and is exemplified with linear mixed models. Approximate marginal likelihood techniques using Modified Profile Likelihood ( MPL ), Conditional Profile Likelihood ( CPL ) and Stably Adjusted Profile Likelihood ( SAPL ) are also presented and offer an alternative to the approximate integration techniques. The asymptotic techniques are then applied to the heteroscedastic t when the degrees of freedom is known to form two distinct REMLs for the scale parameters. The first approximation uses the Partial Laplace approximation to form a REML for the scale parameters, whereas, the second uses the approximate marginal likelihood technique MPL. For each, the estimation of the location and scale parameters is discussed and computational algorithms are presented. For comparison, the heteroscedastic t for known degrees of freedom using ML and the two new REML equivalents are illustrated with an example and a comparative simulation study. The model is then extended to incorporate the estimation of the degrees of freedom parameter. The estimating equations for the location and scale parameters under ML are preserved and the estimation of the degrees of freedom parameter is integrated into the algorithm. The approximate REML techniques are also extended. For the Partial Laplace approximation the estimation of the degrees of freedom parameter is simultaneously estimated with the scale parameters and therefore the algorithm differs only slightly. The second approximation uses SAPL to estimate the parameters and produces approximate marginal likelihoods for the location, scale and degrees of freedom parameters. Computational algorithms for each of the techniques are also presented. Several extensive examples, as well as a comparative simulation study, are used to illustrate ML and the two REML equivalents for the heteroscedastic t with unknown degrees of freedom. The thesis is concluded with a discussion of the new techniques derived for the heteroscedastic t distribution along with their advantages and disadvantages. Topics of further research are also discussed. / Thesis (Ph.D.)--School of Agriculture and Wine, 2005.

Thesis (Ph.D. ) -- McMaster University, 1998. / Includes bibliographical references (leaves 75-81). Also available via World Wide Web.

Thesis (Ph.D.)--Duquesne University, 2007. / Title from document title page. Abstract included in electronic submission form. Includes bibliographical references (p. 138-149) and index.