Background: Prolonged sitting in an automobile seat may alter the passive tissue stiffness of the lumbar spine differentially in males and females. Gender specific ergonomic interventions may be indicated for the automobile seat design. Purpose: To compare time-varying passive lumbar spine stiffness in response to a two hour simulated driving trial with time-varying lumbar spine and pelvic postures during sitting in an automobile seat. A secondary purpose was to investigate gender differences in lumbar spine stiffness, seat/occupant pressure profile, discomfort rating and posture. Methods: Twenty (10 males, 10 females) subjects with no recent history of back pain were recruited from a university population. Participants completed a simulated driving task for two hours. Passive lumbar range of motion was measured on a customized frictionless jig before, halfway through and at the end of the two-hour driving trial. Changes in the passive moment-angle curves were quantified using the transition zone slopes, breakpoints and maximum lumbar flexion angles. Lumbar spine and pelvic postures were monitored continuously during the simulated driving trial with average and maximum lumbar flexion angles as well as pelvic tilt angles being calculated. Results: Both men and women initially demonstrated an increase in transitional zone stiffness after 1 hour of sitting. After 2 hours of sitting, transitional zone stiffness was found to increase in males and decrease in females. During sitting, women were found to sit with significantly greater lumbar flexion than males and to significantly change the amount of lumbar flexion over the 2 hour period of simulated driving. Conclusions: Postural differences during simulated driving were demonstrated between genders in this study. In order to prevent injury to the passive elements of the spine during prolonged driving, gender specific ergonomic interventions, such as improved lumbar support, are indicated for the automobile seat.

Vibration isolation is a common approach to reduce the undesired vibration of a dynamic system from its surrounding. The common material used for the vibration isolator is rubber (for example) which is known to be environmentally unfriendly. This thesis presents a study on the use of corrugated cardboard for the vibration isolator, which is known to be a highly environment-friendly material. The focus of the study is on understanding and modeling of stiffness and damping of cardboard when it or its system (several cardboards) is used for isolating the vibration coming from the vertical direction of cardboard. In this thesis, a study is presented of finite element modeling of stiffness of corrugated cardboard in its vertical direction with the aim of overcoming two major shortcomings in modeling in the current literature: (1) the width effect is neglected even for cardboard with its width greater than length and (2) the non-linear constitutive relation is not accurately determined. Indeed, it is likely that these shortcomings are responsible for inaccuracy with the models in the current literature to predict the stiffness and peak load. Further, a test bed was set up for the measurement of damping of cardboards in this study. This thesis also presents an application of the theoretic development in the stiffness and damping of corrugated cardboard to design an isolator for the vacuum pump at Canadian Light Source. Several conclusions are drawn from this study: (1) modeling with consideration of the width effect and non-linear constitutive relation is necessary to improve the accuracy of prediction of stiffness of cardboard; (2) set up for the measurement of damping of cardboard is accurate; and (3) cardboard systems are feasible for vibration isolation in terms of the reduction of amplitude of vibration. The contribution of this thesis includes: (1) providing a finite element method for modeling of corrugated cardboards which have a complex non-linear constitutive relation, variable contact configuration, and 3D geometrical effect and (2) providing the feasibility of proving that corrugated cardboard can be used for vibration isolation.

In this work the influence of Under Sleeper Pads on the dynamic forces on a railway track is investigated. A special interest is devoted to the effect of using Under Sleeper Pads in a railway track with changing vertical stiffness. The contact force between wheel and rail and the ballast contact forces are examined. For the investigation a finite element model with the length of thirty sleepers is created and calculations are performed with the software LS-DYNA. Three different cases of varying vertical track stiffness are studied: the transition from an embankment to a bridge, a randomly varying track stiffness along the railway track and hanging sleepers.

The aim of this thesis was to evaluate the use of dynamic excitation as a method for stiffness and strength grading of wet side boards of narrow dimensions. The need for such an investigation has previously been identified in an ongoing research project in which the possibility to use side boards as lamellae in wet glued glulam beams is investigated.      The assessment of the dynamic excitation method was carried out by means of experimental work and measurements.. The approach was quantitative in the sense that the data was collected through experiments performed on a rather large population and that the results were analyzed using statistical methods.      To investigate the effect of moisture content on stiffness of narrow dimension, side boards, the stiffness was measured in three states: - in wet state, before splitting the boards, - in wet state, after splitting the boards, and - in dry state (splitted boards).      The conclusion, after calculations and analysis of all the results, was that the natural frequency and stiffness of wet boards could, with a high degree of reliability, be predicted by use of the dynamic excitation method. There was a strong correlation in stiffness between wet state split boards and dry state split boards, with a coefficient of determination of 0.93.

Information about dynamic tire properties has always been important for drivers of wheel driven vehicles. With the increasing amount of systems in modern vehicles designed to measure and control the behavior of the vehicle information regarding dynamic tire properties has grown even more important. In this thesis a number of methods for modeling and estimating dynamic tire properties have been implemented and evaluated. The more general issue of estimating model parameters in linear and non-linear vehicle models is also addressed. We conclude that the slope of the tire slip curve seems to dependent on the stiffness of the road surface and introduce the term combined stiffness. We also show that it is possible to estimate both longitudinal and lateral combined stiffness using only standard vehicle sensors.

An age-related decline in cerebral blood flow (CBF) is widely acknowledged. However, uncertainty exists as to whether this reduction is the result of a reduced metabolic demand (cerebral atrophy) or an impaired delivery system (cerebrovascular disease). The purpose of these experiments was to examine the relationship of CBF and dynamic cerebrovascular regulation with changes in common carotid intima-media thickness (cIMT), brachial-ankle pulse wave velocity (baPWV) and common carotid distensibility. Additionally, we took an exploratory view into the effect of vascular aging and CBF reduction on brain function, as expressed through the performance of motor and cognitive tasks. An important finding in elderly participants was that seated anterior CBF declined as a function of arterial stiffness, independently of age. Linear regression analysis developed a model that predicts CBF drops 22 ml/min (95% confidence interval (CI): 6, 38) for each 100 cm/s increase in baPWV and 8 ml/min (95% CI: 1, 15) for each additional year in age. The effect of baPWV appears to be mediated through an increase in cerebrovascular resistance (r2 = 0.84, p < 0.0001). Additionally, CBF showed postural dependency and the volume of the drop in CBF between supine and seated positions was greatest in elderly participants (YOUNG: 65 ± 81 ml/min; ELDERLY: 155 ± 119 ml/min; p = 0.001). Despite this negative impact of vascular aging on steady state flow, dynamic regulation does not appear to be affected. Cerebrovascular responses to an acute drop in blood pressure or to activation of the motor cortex were not attenuated in the elderly participants. Finally, seated CBF had modest directionally relevant relationships with perceptuo-motor and complex sequencing processes; while cIMT appeared to influence performance on initiation and inhibition tasks.

Electrostatically actuated parallel-plate MEMS tunable capacitors are desired elements for different applications including sensing, actuating and communications and RF (radio frequency) engineering for their superior characteristics such as quick response, high Q-factor and small size. However, due to the nature of their coupled electrostatic-structural physics, they suffer from low tuning range of 50% and have nonlinear capacitance-voltage (C-V) responses which are very sensitive to the voltage change near pull-in voltage. Numerous studies in the literature introduce new designs with high tunability ranging from 100% to over 1500%, but improvement of the nonlinearity and high sensitivity of the capacitor response have not received enough attention. In this thesis, novel highly tunable capacitors with high linearity are proposed to reduce sensitivity to the voltage changes near pull-in. The characteristic equations of a perfectly linear capacitor are first derived for two- and three-plate capacitors to obtain insight for developing linear capacitance-voltage responses. The devices proposed in this research may be classified into three categories: designs with nonlinear structural rigidities, geometric modifications and flexible moving electrodes. The concept of nonlinear supporting beams is exploited to develop parallel-plate capacitors with partially linear C-V curves. Novel electrodes with triangular, trapezoidal, butterfly, zigzag and fishbone shapes and structural/geometric nonlinearities are used to increase the linearity and tuning ratio of the response. To investigate the capacitors' behavior, an analytical approximate model is developed which can drastically decrease the computation time. The model is ideal for early design and optimization stages. Using this model, design variables are optimized for maximum linearity of the C-V responses. The results of the proposed modeling approach are verified by ANSYS FEM simulations and/or experimental data. When the fabrication process has dimensional limitations, design modifications and geometric enhancements are implemented to improve the linearity of the C-V response. The design techniques proposed in this thesis can provide tunabilities ranging from 80% to over 350% with highly linear regions in resulting C-V curves. Due to the low sensitivity of the capacitance to voltage changes in new designs, the entire tuning range is usable. Furthermore, the effect of fabrication uncertainties on parallel-plate capacitors performance is studied and a sensitivity analysis is performed to find the design variables with maximum impact on the C-V curves. An optimization method is then introduced to immunize the design against fabrication uncertainties and to maximize the production yield for MEMS tunable capacitors. The method approximates the feasible region and the probability distribution functions of the design variables to directly maximize the yield. Numerical examples with two different sets of design variables demonstrate significant increase in the yield. The presented optimization method can be advantageously utilized in design stage to improve the yield without increasing the fabrication cost or complexity.

Background: Prolonged sitting in an automobile seat may alter the passive tissue stiffness of the lumbar spine differentially in males and females. Gender specific ergonomic interventions may be indicated for the automobile seat design. Purpose: To compare time-varying passive lumbar spine stiffness in response to a two hour simulated driving trial with time-varying lumbar spine and pelvic postures during sitting in an automobile seat. A secondary purpose was to investigate gender differences in lumbar spine stiffness, seat/occupant pressure profile, discomfort rating and posture. Methods: Twenty (10 males, 10 females) subjects with no recent history of back pain were recruited from a university population. Participants completed a simulated driving task for two hours. Passive lumbar range of motion was measured on a customized frictionless jig before, halfway through and at the end of the two-hour driving trial. Changes in the passive moment-angle curves were quantified using the transition zone slopes, breakpoints and maximum lumbar flexion angles. Lumbar spine and pelvic postures were monitored continuously during the simulated driving trial with average and maximum lumbar flexion angles as well as pelvic tilt angles being calculated. Results: Both men and women initially demonstrated an increase in transitional zone stiffness after 1 hour of sitting. After 2 hours of sitting, transitional zone stiffness was found to increase in males and decrease in females. During sitting, women were found to sit with significantly greater lumbar flexion than males and to significantly change the amount of lumbar flexion over the 2 hour period of simulated driving. Conclusions: Postural differences during simulated driving were demonstrated between genders in this study. In order to prevent injury to the passive elements of the spine during prolonged driving, gender specific ergonomic interventions, such as improved lumbar support, are indicated for the automobile seat.

Fall-related hip fractures are a substantial public health issue. Unfortunately, little is known about whether the effective stiffness of the pelvis, a critical component governing impact force during lateral falls, differs substantially across different segments of the population. The objective of this thesis was to enhance the knowledge base surrounding pelvis impact dynamics by assessing the influence of gender and body mass index (BMI) on the effective stiffness of the pelvis, and on resulting peak loads applied to the hip, during sideways falls. Towards this end I conducted pelvis release trials (in which the pelvis was suspended and suddenly released onto a force plate) with males and females with low (<22) and high (>28) BMIs. One resonance-based (kvibe), and three force-deflection based (k1st, kcombo 300, and kcombo opt) methods of effective pelvic stiffness estimation were examined. The resulting stiffness estimates, and peak forces sustained during the pelvis release experiments, were compared between each BMI and sex group. The optimized force-deflection stiffness estimation method, kcombo opt provided the strongest fit to the experimental data. Strong main effects of BMI (f (1,13) = 10.87, p = 0.003) and sex (f (1,13) = 5.97, p = 0.022) were found for this stiffness estimation method. Additionally, a significant BMI-sex interaction was observed (f (3,6) = 5.31, p = 0.030), with low BMI males having much higher stiffness estimates than any other group. Normalized peak forces were higher in low BMI participants than in high BMI participants (f(1,13)=24.9, p<0.001). Linear regression demonstrated that peak impact force was positively associated with effective pelvic stiffness (β = 0.550, t(25) = 3.110, p=0.005), height (β = 0.326, t(25) = 2.119, p=0.045) and soft tissue thickness (β = 0.785, t(25) = 4.573, p<0.001). This thesis has demonstrated that body habitus and sex have significant effects on the stiffness of the pelvis during lateral falls. These differences are likely related to a combination of soft tissue and pelvic anatomical differences between BMI and sex groups. Pelvic stiffness, along with other easily collected variables, may be helpful in predicting peak forces resulting from lateral falls in the elderly. Differences in pelvic stiffness estimates between BMI and sex groups, and estimation method, necessitate careful consideration. These data will aid in selecting the most appropriate pelvic stiffness parameters when modeling impact dynamics for higher energy falls.

Smoking and environmental tobacco smoke (ETS) exposure are major risk factors for cardiovascular disease (CVD), although the exact components and pathophysiological mechanisms responsible for this association remain unclear. Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are ubiquitous environmental contaminants that form during organic material combustion and are thus found in cigarette smoke, vehicle exhaust particles, and air pollution. We hypothesize that PAHs are key agents responsible for mediating the cigarette smoke effects in the cardiovascular system, including increased oxidative stress, inflammation, and arterial stiffness.<p> Arterial stiffness is a powerful, independent predictor of cardiovascular risk and is regulated, in part, by vasoactive mediators derived from the endothelium. The first objective of this project was to determine whether pulse wave dP/dt collected from radiotelemetry-implanted rats is a reliable indicator of changes in arterial stiffness following administration of vasoactive drugs or acute ETS exposure. Anaesthetized rats were administered a single dose of saline (vehicle control), acetylcholine, norepinephrine, and N(G)-nitro-L-arginine methyl ester (L-NAME) via the tail vein, allowing a washout period between injections. Acetylcholine decreased and norepinephrine increased dP/dt compared to saline vehicle. Injection of the nitric oxide (NO) synthase inhibitor L-NAME decreased plasma nitrate/nitrite (NOx), but transiently increased dP/dt. For the ETS experiment, rats were exposed for one hour to sham, low dose ETS, or high dose ETS. Exposure to ETS did not significantly alter dP/dt or plasma endothelin-1 (ET-1) levels, but increased plasma NOx levels at the high ETS exposure and increased plasma nitrotyrosine levels in both ETS groups. In conclusion, acute changes in NO production via acetylcholine or L-NAME alter the arterial pulse wave dP/dt consistently with the predicted changes in arterial stiffness. Although acute ETS appears to biologically inactivate NO, a concomitant increase in NO production at the high ETS exposure may explain why ETS did not acutely alter dP/dt.<p> The second objective of this project was to compare the effects of subchronic ETS and BaP exposure on circadian blood pressure patterns, arterial stiffness, and possible sources of oxidative stress in radiotelemetry-implanted rats. Pulse wave dP/dt was used as an indicator of arterial stiffness, and was compared to both structural (wall thickness) and functional (NO production and bioactivity, ET-1 levels) features of the arterial wall. In addition, histology of lung, heart, and liver were examined as well as pulmonary and hepatic detoxifying enzyme activity (cytochrome P450 specifically CYP1A1). Daily ETS exposure for 28 days altered the circadian pattern of heart rate and blood pressure in rats, with a loss in the normal dipping pattern of blood pressure during sleep. Subchronic ETS exposure also increased dP/dt in the absence of any structural modifications in the arterial wall. Although NO production and ET-1 levels were not altered by ETS, there was increased biological inactivation of NO via peroxynitrite production (as indicated by increased plasma nitrotyrosine levels). Thus, vascular stiffness and failure of blood pressure to dip precede structural changes in rats exposed to ETS for 28 days. Exposure to ETS also caused increased number of lung neutrophils as well as increased CYP1A1 activity in lung microsomes.<p> Since ETS-induced increases in arterial stiffness occurred as early as day 7, radiotelemetry-implanted rats were exposed daily to intranasal BaP for 7 days. Similar to ETS, BaP exposure altered circadian blood pressure patterns and reduced blood pressure dipping during sleep. Thus, in support of part of our hypothesis, the PAH component of cigarette smoke may be responsible for the ETS-induced increase in blood pressure and the loss of dipping pattern during sleep. Increased neutrophil recruitment was observed in the lungs of both ETS- and BaP-exposed rats, suggesting that lung inflammatory reactions may be involved in the disruption of circadian blood pressure rhythms. Unlike ETS however, BaP exposure did not significantly alter pulse wave dP/dt, endothelial function, or lung CYP1A1 activity. Thus, contrary to our hypothesis, the reduction in NO bioactivity and increased arterial stiffness caused by ETS cannot be explained by BaP at the dose and length of the exposure in the current study. Production of reactive metabolites in the lung following ETS exposure may be responsible, at least in part, for the increases in oxidative stress in the vasculature, leading to reduced NO bioactivity and increased arterial stiffness. Oxidative stress caused by BaP exposure may have been insufficient to reduce NO bioactivity in the peripheral vasculature. Therefore arterial stiffness was not increased and factors other than NO may be responsible for the increase in blood pressure observed with ETS and BaP exposure.