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Regulation of the transcription factor Neurogenin 3 by post-translational modificationHurley, Christopher James January 2013 (has links)
No description available.
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Evolution of transcription factor repertoires in the SaccharomycotinaHess, Jaqueline January 2011 (has links)
No description available.
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Mechanisms of induced pluripotency : role of the homeodomain transcription factor NanogTheunissen, Thorold Wieger January 2012 (has links)
No description available.
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The in vivo specificity of HOX proteins in DrosophilaChoo, Siew Woh January 2011 (has links)
No description available.
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Investigation of the role of PITX2 in ocular expression pathways and human diseaseStrungaru, Marcela Hermina Unknown Date
No description available.
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Combinatorial gene regulation by T-domain transcription factorsJahangiri, Leila January 2012 (has links)
No description available.
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Investigating the role of Oct4 during lineage specification in the physiological context of mouse embryonic developmentChia, Gloryn Le Bin January 2013 (has links)
No description available.
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Determining the transcription factor code that specifies CiA interneuronsCerda-Moya, Gustavo Andrés January 2012 (has links)
No description available.
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The Role of Cys2-His2 Zinc Finger Transcription Factors in Polyol Metabolism, Asexual Development and Fumonisin Biosynthesis in Fusarium verticillioidesMalapi-Wight, Martha Maria 03 October 2013 (has links)
The ascomycete Fusarium verticillioides (Sacc.) Nirenberg (teleomorph: Gibberella moniliformis Wineland) causes stalk and ear rots on maize worldwide. In addition to the economic losses due to reduced yield, the fungus produces fumonisins on infected corn. One of the unanswered questions in mycotoxin research is how fungi perceive and respond to various extracellular stimuli and produce mycotoxins. To date, extensive research has been performed on important signaling pathways that regulate mycotoxin biosynthesis, but little is known about the downstream target genes, notably transcription factors (TFs). While the roles of TFs have shown to be critical in eukaryotic transcription regulation, only a few have been characterized in F. verticillioides. TFs with zinc fingers have been reported in all living organisms, and in fungal species, members of the Cys2-Hys2 (C2H2) zinc finger TF family are predicted to be involved in cell differentiation, carbon utilization, and development. Using the available genomic resources, I constructed a library of C2H2 TF deletion mutants, and identified SDA1, FvFLBC and CHT1 genes with a potential role in carbon utilization, development and fumonisin B1 (FB1) biosynthesis. The Δsda1 strain showed complete growth inhibition when using sorbitol as the sole carbon source and produced higher levels of FB1 when grown on corn kernels. In addition, the Δsda1 strain produced less number of conidia compared to the wild-type progenitor. Through gene complementation, I also demonstrated that F. verticillioides SDA1 and Trichoderma reesei ACE1 are functionally conserved. FvFLBC acts as a regulator of asexual development but not FB1 biosynthesis. I also discovered that the FvFlbC N-terminus is critical for conidia production. CHT1 is associated with asexual development, fumonisin biosynthesis and pigmentation. Characterization of key signal transduction pathways, and more importantly the function of SDA1, FvFLBC and CHT1, should facilitate the elucidation of the mechanisms and regulations of growth, development, and secondary metabolism in F. verticillioides. The outcome of this study may help us determine how to minimize F. verticillioides contamination of crops and the resulting mycotoxins, providing safer and higher value corn in the US and worldwide.
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The roles of Sox2 and Sox18 in hair type specification and pigmentation /Chan, N. S., Michelle. January 2007 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2007. / Also available online.
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