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No. of bitstreams: 1 JoseRodolfoLopesDePaivaCavalcanti_TESE.pdf: 2156602 bytes, checksum: 000c3eafedc8a66a1a55425b0168fd4a (MD5) Previous issue date: 2015-04-30 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq / Sabe-se que o grupo das catecolaminas ? integrado pela dopamina, noradrenalina e adrenalina e que a s?ntese dessas subst?ncias se d? de modo sequencial, sendo a enzima tirosina-hidroxilase reguladora da fase inicial deste processo. Neste sentido, a 3- hidroxitiramina/dopamina ? precursora da s?ntese de noradrenalina e adrenalina e ainda possui a capacidade de atuar como neurotransmissor na por??o central do sistema nervoso. Os tr?s principais n?cleos dopamin?rgicos, chamados zona retrorubral (grupo A8), subst?ncia negra pars compacta (grupo A9) e ?rea tegmentar ventral (grupo A10), est?o dispostos na por??o die-mesencef?lica e est?o envolvidos em tr?s vias, a mesostriatal, mesol?mbica e mesocortical. Estas vias est?o relacionadas diretamente com diversas manifesta??es comportamentais como controle da motricidade, sinaliza??o de recompensa na aprendizagem comportamental, motiva??o e nas manifesta??es patol?gicas da Doen?a de Parkinson e esquizofrenia. Considerando-se a relev?ncia desses, o objetivo do trabalho foi caracterizar morfologicamente os n?cleos dopamin?rgicos (A8, A9 e A10) do sagui (Callithrix jacchus) mediante estudo citoarquitet?nico e imunoistoqu?mico contra tirosina-hidroxilase. O sag?i ? um primata neotropical, cujas caracter?sticas morfofuncionais repercutem na adequabilidade de uso deste animal em pesquisas de ordem biom?dica. Sec??es coronais dos enc?falos de seis animais foram submetidas ? colora??o pelo m?todo de Nissl e immunoistoqu?mica para tirosinsa-hidroxilase. Com base na morfologia dos neur?nios, foi poss?vel subdividir o grupo A10 em sete regi?es: n?cleo interfascicular, linear rostral e linear caudal, situados na linha m?dia; paranigral e o parainterfascicular, situados na zona intermedi?ria; a por??o rostral da ?rea tegmentar ventral e o n?cleo parabraquial pigmentado, situados na por??o dorsolateral do tegmento mesencef?lico. O grupo A9 foi subdividido em quatro regi?es: subst?ncia negra camadas dorsal e ventral; subst?ncia negra conjuntos lateral e medial. Por ?ltimo, n?o foram indentificadas subdivis?es no grupo A8. Conclu?-se que A8, A9 e A10 s?o filogeneticamente conservados entre as esp?cies, por?m percebe-se a necessidade de se ampliar os estudos acerca das organiza??es subnucleares, seja investigando a sua ocorr?ncia em outras esp?cies de primatas, seja investigando a sua relev?ncia funcional. / It is known that the catecholamine group is constituted by dopamine, noradrenaline and adrenaline, in which the synthesis is regulated by an enzyme named tyrosine hydroxylase. Thus, 3-hydroxytyramine/dopamine (DA) is a precursor of the noradrenaline and adrenaline synthesis and acts as a neurotransmitter in the central nervous system. The three main nuclei, named the retrorubral field (A8 group), the substantia nigra pars compacta (A9 group) and the ventral tegmental area (A10 group), are arranged in the die-mesencephalic portion and are involved in three complexes circuitries - the mesostriatal, mesolimbic and mesocortical pathways. These pathways are related to behavioral manifestations, motricity, learning, reward and pathologies such as Parkinson?s Disease and Schizophrenia. Thus, the aim of this study was to perform de morphological analysis of the A8, A9 and A10 nuclei of the common marmoset (Callithrix jacchus). The marmoset is a neotropical primate, whose morphological and functional characteristics supports the suitability of use of this animal in biomedical research. Coronal sections of the marmoset brain were submitted to cytoarchitectonic characterization and TH-immunohistochemistry. Based on the morphology of the neurons, it was possible to subdivide the A10 group in seven regions: interfascicular nucleus, raphe rostral linear nucleus and raphe caudal linear nucleus, in the middle line; paranigral and parainterfascicular nucleus, in the middle zone; rostral portion of the ventral tegmental area nucleus and parabrachial pigmented nucleus, located in the dorsolateral portion of the mesencephalic tegmentum. A9 group was divided into four regions: substantia nigra compacta dorsal and ventral tiers; substantia nigra compacta lateral and medial clusters. No subdivisions were founded into A8 group. These results revealed that A8, A9 and A10 are phylogenetically conserved between species, but it?s necessary to expand the studies about this compartmentalization, investigating its occurrence in other primate species or investigating its functional relevance.