Epilepsy represents the most common neurological disease, its prevalence reaching up to 1%, and around 30% of patients become refractory to treatment. In these patients, epilepsy surgery is often their only chance for disease-free life. Aetiology of epilepsy is heterogenous; we recognize genetic, structural- metabolic epilepsy and epilepsy with unknown aetiology. Patients with focal pharmacoresistant epilepsy may become candidates for epilepsy surgery; the same does not apply to patients with metabolic or neurodegenerative disease. Multiple factors influence decision about epilepsy surgery, the most important ones being (i) the type of known or presumed structural lesion and (ii) the possibility to precisely delineate the epileptogenic zone (the area of seizure generation). Another factor that needs to be accounted for is the proximity of epileptogenic zone to the eloquent cortical areas (the areas with important neurological functions, e.g. motor or speech functions). Epilepsy surgery principally aims for complete removal the epileptogenic zone, and subsequently for complete freedom from seizures. Hypothesis on the localization of the epileptogenic zone arises from the combined information gained from various diagnostic, mostly neuroimaging, methods. Cognitive profile examination includes...

Objective: The goal of this study was to investigate relations between aspects of cognitive control and emotion in typically developing children, 7 to 9 years of age. This was investigated by examining performance on n-back working memory tasks that varied according to the level of cognitive control and emotion (e.g., faces, reward value) processing required. Relations between n-back performance and parental questionnaires of behavior were also examined. Participants & Methods: Participants included 77 typically developing children, 7 to 9 years of age. Each participant completed two novel n-back tasks. The first task involved working memory (0-back, 1-back, and 2-back levels) for emotional faces (neutral, happy, sad). The second task involved working memory (0-back, 1-back, and 2-back levels) for number stimuli with differing levels of reward (two tokens, six tokens). Matrix Reasoning was also completed as a screening measure of cognitive function. Parents completed a Child History questionnaire, the BRIEF, Conners 3 AI-Parent, and the Emotion Questionnaire. iv Results: No significant main effect was found for emotive content of stimuli or reward value. A significant effect of n-back level was found, both in terms of per hit RT and accuracy rates for both Emotive and Reward n-back. Significant relations were found between age and Sad conditions on 1-back and 2-back of the Emotive n-back, as well as 2-back conditions in the Reward n-back. No relations were found between BRIEF scales and performance on either n-back task. Significant correlations were found between Emotionality and accuracy measures of the Reward n-back task. Conclusions: This study made several important contributions to understanding emotion and cognitive control interplay. These contributions include introducing novel tasks for assessing this interplay, and providing insight on developmental relations and interaction between emotion and working memory and individual differences in emotionality in day to day life. Results are discussed with respect to theories of emotional and cognitive control interplay, temperament and individual differences, and the development of cognitive control. Directions for future research and implications are discussed.

[pt] Diversos estudos apontam o efeito do nível de escolaridade parental no desenvolvimento das funções cognitivas, em especial a linguagem e as funções executivas. Evidenciam a importância da interação entre o cuidador e a criança, a qualidade da estimulação e a promoção de experiências de desenvolvimento, propiciadas a criança, como fundamentais para o desenvolvimento das funções executivas. Há poucos estudos desse efeito no desenvolvimento de crianças brasileiras. O objetivo da dissertação foi investigar o efeito do nível de escolaridade dos pais, separadamente, no desempenho em tarefas de memória de longo prazo, memória de trabalho, controle inibitório e flexibilidade cognitiva de crianças e adolescentes com baixo nível socioeconômico na cidade do Rio de Janeiro. Participaram do estudo 352 crianças entre 7 a 15 anos de escolas privadas com perfil de baixo nível socioeconômico na cidade do Rio de Janeiro. Os instrumentos utilizados foram a Figura Complexa de Rey, a Aprendizagem auditivo verbal de Rey, o paradigma de Stroop e as tarefas de Fluência Verbal fonêmica e semântica. Os resultados mostraram efeitos para a escolaridade de ambos os pais. Resultados sistemáticos aconteceram na fluência verbal, na faixa de 9-10 anos. Não foram encontrados efeitos significativos em controle inibitório e memória de trabalho. O efeito da escolaridade parental apareceu de forma sistemática em funções executivas, mas não em outras funções, em uma amostra homogênea, o que levanta a ideia de que outros fatores como a renda e a cultura, se somam ao efeito ambiental no desenvolvimento cognitivo. / [en] Several studies demonstrated the effect of parents educational level in the development of cognitive functions, especially language and executive functions. Highlight the importance of interaction between the caregiver and the child, the quality of stimulation and promotion of development experiences afforded the child, as fundamental for the development of executive functions. There are few studies of this effect in the development of Brazilian children. The objective of the study is to analyze the effect of the education level of parents, separately, in the cognitive performance of long-term memory, working memory, inhibitory control and cognitive flexibility in children and adolescents living at Rio de Janeiro with low socioeconomic status. The study included 352 children between 7-15 years of private schools with low socioeconomic profile students of city of Rio de Janeiro. The instruments used were the Rey–Osterrieth Complex Figure Test, the Rey Auditory Verbal Learning Test, the Stroop test (Victoria Version) and Verbal Fluency phonemic and semantic. The results showed effects on education of both parents. Systematic results happened in verbal fluency, in the 9-10 year group. There were no significant effects on inhibitory control and working memory. The effect of parental education appeared systematically in executive functions, but not in other functions, raises the idea that other factors such as income and culture add to the environmental effect on cognitive development.