In 2006, an amphoteric molecule containing both an aldehyde and an unprotected amine was reported in the Yudin group by Dr. Ryan Hili. The unprotected aziridine aldehyde exists as homochiral dimers. Furthermore, due to the reversibility of the hemiacetal formation, the free aldehyde is available to undergo a wide array of reactions including an Ugi multicomponent reaction to give the final peptide macrocycle. Thus far, the mechanistic pathway involved in the Ugi reaction between S-trans aziridine aldehyde dimer and L-amino acids in the presence of tert-butyl isocyanide has given high diastereoselectivity whereas low diastereoselectivity is observed if the aziridine dimer is of the opposite stereochemistry. Herein, preliminary results show that a S-cis aziridine aldehyde with either a D or L-secondary amino acid gives high diastereoselectivity showing that the reaction is under Felkin-Ahn control.

In 2006, an amphoteric molecule containing both an aldehyde and an unprotected amine was reported in the Yudin group by Dr. Ryan Hili. The unprotected aziridine aldehyde exists as homochiral dimers. Furthermore, due to the reversibility of the hemiacetal formation, the free aldehyde is available to undergo a wide array of reactions including an Ugi multicomponent reaction to give the final peptide macrocycle. Thus far, the mechanistic pathway involved in the Ugi reaction between S-trans aziridine aldehyde dimer and L-amino acids in the presence of tert-butyl isocyanide has given high diastereoselectivity whereas low diastereoselectivity is observed if the aziridine dimer is of the opposite stereochemistry. Herein, preliminary results show that a S-cis aziridine aldehyde with either a D or L-secondary amino acid gives high diastereoselectivity showing that the reaction is under Felkin-Ahn control.

A Component Oriented Software Engineering (COSE) modeling environment is enhanced with the capability to import executable components and deliver applications through their composition. For this purpose, an interface layer that utilizes JAR libraries as components has been developed. Also, Domain Engineering process has been applied to Geographical Information Systems (GIS) domain and utilized towards converting the environment to a development framework. The interface layer imports JAR libraries into the COSECASE tool, which is a graphical tool supporting COSE approach and COSE Modeling Language (COSEML). As a result, systems can be designed using abstractions and then implemented by corresponding deployed components. Imported code is made available to the COSECASE environment through this interface layer. Also, Domain Analysis, Domain Design, and Domain Implementation phases of Domain Engineering process have been applied to the GIS domain. Components developed in this Domain Implementation phase have been imported into COSECASE. A simple GIS application has been designed and generated through the interface layer of COSECASE for demonstration purposes.

Tools and environments have aided developers in producing software since compilers and editors became standard offerings with operating systems. A major challenge for the tools and environments community has been to find ways to build and integrate tools so that they, or capabilities between them, can be easily adapted for use in new contexts. The "Eclipse" Project is an open source software development project dedicated to providing a robust, full-featured, commercial-quality, industry platform for the development of highly integrated tools. The mission of the "Eclipse" Project is to adapt and evolve the eclipse technology to meet the needs of the eclipse tool building community and its users, so that the vision of eclipse as an industry platform is realized. "Eclipse" uses an innovative plug-in architecture allowing near-infinite extensions to the base IDE. Unlike other opensource projects that don't allow proprietary derivative works, "Eclipse" can be extended with proprietary plug-ins, repackaged, and sold commercially. Aspect-Oriented programming (AOP) is a new programming paradigm based on the idea that computer systems are better programmed by separately specifying the various concerns of a system and some description of their relationships, and then relying on mechanisms in the underlying AOP environment to weave or compose them together into a coherent program. While the tendency in Object-Oriented Programming is to find commonality among classes and push it up in the inheritance tree, AOP attempts to realize scattered concerns as first-class elements, and eject them horizontally from the object structure. The primary goals of this research were 1. Incorporation of "Component Pascal" into "Eclipse". "Component Pascal"was a command line compiler that is targeted to a variety of platforms including JVM and.NET. 2. Research and design visual programming tools for "Component Pascal" in "Eclipse", in particular visual tools that support aspect-oriented views of software. These objectives are now complete and a plug-in has been developed that enables the development of "Component Pascal" software within "Eclipse". Aspect-Orientation has been incorporated directly into the "Component Pascal" compiler.

This thesis is devoted to a component model for Web application and the corresponding tools for its development. The model is described after the review of various existing Web application development methods and models. A case study is also provided to support the analysis. -- abstract / Thesis (PhD)--University of South Australia, 2003.

Strategies for reuse of components are important in order to create a closed loop manufacturing system. Over decades, the notion has been gaining ground due to environmental and legislative reasons. Reuse of components is desirable and in many cases might be economically beneficial. However, the implementation of reuse strategies has been hindered by the requirement of reliable methodologies to assess the remaining life and reuse potential of used components. The estimation of the remaining life is problematic as the useful life of a component is affected by several causes of obsolescence. The common causes are due to physical and technological issues. So far, little research has attempted to address these issues simultaneously, and integrating them. This thesis seeks to develop methodologies that aid in predicting the integrated remaining lifetime of used components. There are three core parts of this research. First, the methodology determines the remaining life of used components from the physical lifetime perspective. This was derived from the estimation of physical failure using failure rate data, and the statistical analysis of usage intensity age as obtained from customers survey. Second, the research presents the use of the technological forecasting technique to predict the remaining technological life. As it is influenced by the technology progress, the forecast was developed on the basis of product technology clusters and market trend extrapolation analysis. Finally, the resulting estimations from the two aspects were combined to obtain an integrated assessment for estimating the remaining life of components. The potential for components in a product to be reused is justified when the remaining life is greater than the average expected lifespan of the product. Two cases of domestic appliances – televisions and washing machines were used to highlight and demonstrate the validity of the proposed methodology. The results show that the proposed method provides the practitioners with a promising tool for end-of-life decision making. This is in particularly attractive when used as a preliminary decision support tool prior to the time consuming and costly processes such as disassembly and quality testing.

Thesis (Ph. D.)--University of Alabama at Birmingham, 2007. / Additional advisors: Gary J. Grimes, Chittoor V. Ramamoorthy, Murat N. Tanju, Gregg L. Vaughn, B. Earl Wells. Description based on contents viewed Feb. 12, 2009; title from PDF t.p. Includes bibliographical references (p. 150-158).

Dissertatio (Ph. D.)--Worcester Polytechnic Institute. / Keywords: software maintenance; software evolution; regression test-cases; components; legacy system; incremental software evolution methodology; fine-grained components. Includes bibliographical references (p. 283-294).

Thesis (doctoral)--University of Oulu, 2000. / Includes bibliographical references. Also available on the World Wide Web.

Thesis (Ph. D.)--University of Texas at Dallas, 2007. / Includes vita. Includes bibliographical references (leaves 201-214)