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Extraction of desmosines from urine : an indicator for inflammatory lung damageWinfield, Kaye R January 2007 (has links)
[Truncated abstract] Urinary desmosines have been proposed as a biomarker for inflammatory lung damage. Desmosine, a breakdown product of elastin, is an effective marker of the degradation of elastin and has been studied in many disease scenarios where there is acute and chronic lung inflammation. Lung matrix degradation has been proven in vitro and in vivo with many experiments showing that the excess proteases degrades lung matrix. The secretion of proteases by neutrophils is an innate response of the body to the invasion by micro organisms and when secreted in excess, the protective anti-protease mechanism is swamped. Chronic inflammation and persistent infection eventually leads to bronchiectasis and respiratory failure. Urinary desmosine has been shown to be elevated in respiratory conditions with acute and chronic inflammation . . . Urinary desmosine levels in a large cohort of healthy children have been established using this method and predictive Z-score formulae have been developed to use in children with lung disease. Exploration of these scores in children with CF have shown that the levels of urinary desmosine appear to be sensitive to the clinical setting, where high urinary desmosine levels were present during exacerbation and significantly reduced when treated for infection with antibiotic therapy and physiotherapy. The study of young children under the age of seven was undertaken to determine if the urinary desmosine levels could indicate when lung damage was occurring and to determine what mechanisms might be involved. Since there appeared to be no apparent relationship between elevated desmosines and proteases in the lung in young children with CF, further studies are required to define the mechanisms behind increased elastin metabolism in those children.
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Protein interaction and cell surface trafficking differences between wild-type and [Delta]F508 cystic fibrosis transmembrane conductance regulatorGoldstein, Rebecca F. January 2007 (has links) (PDF)
Thesis (Ph. D.)--University of Alabama at Birmingham, 2007. / Title from first page of PDF file (viewed Feb. 6, 2008). Includes bibliographical references.
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Clinical, immunological and olfactory aspects of sinusitis and nasal polyposis : with special reference to patients with cystic fibrosis /Henriksson, Gert, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.
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Mechanism of MDR protein mediated multidrug resistance /Hoffman, Mary M. January 1997 (has links)
Thesis (Ph. D.)--Cornell University, May, 1997. / Includes bibliographical references (leaves 170-181).
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Epidemiological and immunological studies of environmental mycobacteria : with focus on Mycobacterium abscessus /Jönsson, Bodil, January 2009 (has links)
Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2009. / Härtill 5 uppsatser.
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Sulfated sugars in cystic fibrosis mucins and the effects of sugar sulfation on the growth of Pseudomonas aeruginosa /Chance, Deborah L. January 1997 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 1997. / Typescript. Vita. Includes bibliographical references (leaves 131-132). Also available on the Internet.
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Gating of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels by nucleoside triphosphates /Zeltwanger, Shawn January 1998 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 1998. / "December 1998" Typescript. Vita. Includes bibliographical references (l. 140-148). Also available on the Internet.
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Sulfated sugars in cystic fibrosis mucins and the effects of sugar sulfation on the growth of Pseudomonas aeruginosaChance, Deborah L. January 1997 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 1997. / Typescript. Vita. Includes bibliographical references (leaves 131-132). Also available on the Internet.
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The immunology and infection of the cystic fibrosis lungDrummond Massengale, Andrea Rene. January 1900 (has links)
Thesis (Ph. D.)--West Virginia University, 1999. / Title from document title page. Document formatted into pages; contains xi, 131 p. : ill. Vita. Includes abstract. Includes bibliographical references.
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Rational design of split gene vectors to expand the packaging capacity of adeno-associated viral vectorsGhosh, Arkasubhra, January 2007 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2007. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "December 2007" Includes bibliographical references.
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