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Modulation of the myelopoietic support function of murine bone marrow stroma by ionising radiation : the role of soluble mediators and the effects of putative radioprotective agentsCooper, Simon James January 1998 (has links)
No description available.
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Longitudinal data models for evaluating change in prescribing patternsSithole, Jabulani S. January 2000 (has links)
No description available.
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Application of survival methods for the analysis of adverse event dataMason, Tracey January 1999 (has links)
The concept of collecting Adverse Events (AEs) arose with the advent of the Thalidomide incident. Prior to this the development and marketing of drugs was not regulated in any way. It was the teterogenic effects which raised people's awareness of the damage prescription drugs could cause. This thesis will begin by describing the background to the foundation of the Committee for the Safety of Medicines (CSM) and how AEs are collected today. This thesis will investigate survival analysis, discriminant analysis and logistic regression to identify prognostic indicators. These indicators will be developed to build, assess and compare predictor models produced to see if the factors identified are similar amongst the methodologies used and if so are the background assumptions valid in this case. ROC analysis will be used to classify the prognostic indices produced by a valid cut-off point, in many medical applications the emphasis is on creating the index - the cut-off points are chosen by clinical judgement. Here ROC analysis is used to give a statistical background to the decision. In addition neural networks will be investigated and compared to the other models. Two sets of data are explored within the thesis, firstly data from a Phase III clinical trial used to assess the efficacy and safety of a new drug used to repress the advance of Alzheimer's disease where AEs are collected routinely and secondly data from a drug monitoring system used by the Department of Rheumatology at the Haywood Hospital to identify patients likely to require a change in their medication based on their blood results.
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Cocaine metabolism in Pseudomonas maltophilia MB11LBritt, Adrian John January 1991 (has links)
No description available.
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Cyclooxygenase 2 inflammationGilroy, Derek William January 1997 (has links)
No description available.
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Synthesis of the anthraquinone portion of dynemicin A : Taxanes chiral construction of the A, B and C rings of taxolMagnus, Nicholas Andrew January 1996 (has links)
No description available.
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The lethal and non-lethal effects of ivermectin on cattle dung on the fly Neomyia cornicinaGover, Jane Charlotte January 1995 (has links)
No description available.
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Variation in prescribing in general practiceCarthy, Patricia Ann January 2000 (has links)
No description available.
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The actions of centrally acting muscle relaxants on synpatic reflexes of motoneurones in vitroSiarey, Richard John January 1992 (has links)
No description available.
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Development of enzyme assays for heroin and morphineHolt, Peter-John January 1995 (has links)
No description available.
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