Philosophiae Doctor - PhD / Background: Extended-spectrum beta-lactamase-producing (ESBL) and carbapenemaseproducing Gram-negative bacilli showing resistance to cephalosporins and carbapenems respectively, have been reported from several countries globally and recently among Libyan combatants who have been transferred to European countries for advanced medical care. However, there is a lack of data about their presence in Misrata and in Libya in general. This is the first documented study aimed at investigating the prevalence and resistance mechanisms of ESBL and carbapenemase-producing K. pneumoniae isolates from Misrata. Materials and Methods: Two hundred Gram-negative bacillus isolates were collected and identified from hospitals and pathology laboratories in Misrata. Following antimicrobial susceptibility screening, those showing resistance to cephalosporin and carbapenem were tested for ESBL activity using the Modified double disc synergy test, Sensititer ESBL confirmatory MIC plates and MAST AmpC detection sets D52C and D68C. Carbapenemase activity was detected using RAPIDEC CARBA NP test, Modified Hodge test (MHT), carbapenem inactivation methods (CIM), carbapenem combined test (CCT), and by MAST carba puls set. ESBL and carbapenemases genes were detected using multiplex PCR. Results: K. pneumoniae was the predominant species (85/200) of the 14 species identified, with 56 (65.8%) showing carbapenem resistance, 16 (18.8%) were cephalosporin-resistant carbapenem-susceptible and 13 (15.2%) were susceptible to all antibiotics except ampicillin. OXA-48 was the only carbapenemase detected, with SHV, TEM and CTX-M group 1 found in almost all carbapenem and cephalosporin resistant K. pneumoniae. Rep-PCR analysis revealed multiple clones and some K. pneumoniae strains were genetically related or indistinguishable despite differences in ESBL genes or carbapenemase activity. Conclusion: The findings of this study show that carbapenemase- and ESBL-producing K. pneumoniae are prevalent in Misrata and emphasize the urgent need for optimized infection control and antibiotic stewardship programmes in the Libyan hospitals to prevent further spread of these organisms.

This objectivist, experimental study investigated the influence of virtual expert systems (VES) on the decision accuracy of non-expert consultants within a technology consulting contact centre environment. Because of the overwhelming availability of conceptual information, non-expert consultants experience challenges in making accurate decisions, and would benefit from augmented technologies, such as VES. VES hold the ability to capture and scale large volumes of decision variables for consideration by human experts when making decisions. A total of 40 participants were randomly selected from contact centres in the Eastern Cape and Gauteng provinces of South Africa for this study. Human logic was captured and scaled into a technology fault finding virtual expert and administered as an experiment to group participants. The experimental and control group participants were randomly assigned to the respective groups of 20 participants each. The control group was exposed to the paper-based, fault-finding manual. The pre-test and post-test data were collected based on four decision accuracy measures, namely individual performance, average call handling time, first call resolution and customer service. The Clarify performance system of the participating technology consulting company was used as data collection tool to record the findings used for Chapter 5. Statistical data analyses were performed using ANOVA and two-tailed significance tests to test the relationship between VES and decision accuracy in the pre-test and post-test phases of the study. The study found that the participant scores on the decision accuracy measures were only statistically significant on the measure of first call resolution measure (significance score of a p value <.05). On the other (three) measures, the scores obtained from experimental group participants showed more improvement than that of the control group participants. Consequently, the hypothesis that the use of VES enhance decision accuracy amongst non-expert technology consultants was accepted and the alternative hypothesis rejected. Some limitations pertaining to the resultant Hawthorne effect (the effect when some employees work harder and perform better when they are participants in an experiment) was noted amongst participants. This effect resulted from the use of team leaders in monitoring performance during the experiment and the involvement of the technology consulting company in determining the performance norms of the identified measures. Another limitation of the study related to the size of the sample where only two provinces were included. The limitation may affect the generalisation of results to other future settings when such a study is repeated. It was recommended that future studies in this field should make provision for a larger population, inclusive of other provinces to avoid these limitations.

An expert system for identifying cows to be culled, MAXCULL, was programmed to run on an IBM or compatible personal computer . It was designed to be used with Dairy Herd Improvement (DHI) records as an aid in decision making. MAXCULL used fifty-two health, seventeen reproduction, and thirty-nine production rules in the analysis. MAXCULL was initially developed using two expert system tools. VP-Expert and Super Expert both had inductive abilities and were reasonably priced . VP - Expert was selected to continue the development of the MAXCULL system . The program u sed a rule-based method of storing knowledge, which was obtained from literature reviewed in the health, reproduction and management areas. Three blocks of rules were developed. MAXCULL used a backward- chaining control strategy. The information on each cow was obtained from a special report obtained from DHI Provo . The diagnosis from MAXCULL produced an explanation paragraph identifying possible reasons for removing the cow. Twenty herds with DHI records were identified, ten assigned as controls and ten to be evaluated with the MAXCULL system . General linear model procedures were used to compare thirteen variables after using MAXCULL for one year. No significant differences were noted for any of the variables. The chi- square analysis showed that the decisions of MAXCULL were significantly different from the decisions of the manager. The final survey supports the idea that dairy management expertise can be provided to the dairy manager through an expert system.

Most legal expert systems attempt to implement complex models of legal reasoning. Yet the utility of a legal expert system lies not in the extent to which it simulates a lawyer's approach to a legal problem, but in the quality of its predictions and of its arguments. A complex model of legal reasoning is not necessary: a successful legal expert system can be based upon a simplified model of legal reasoning. ¶ Some researchers have based their systems upon a jurisprudential approach to the law, yet lawyers are patently able to operate without any jurisprudential insight. A useful legal expert system should be capable of producing advice similar to that which one might get from a lawyer, so it should operate at the same pragmatic level of abstraction as does a lawyer - not at the more philosophical level of jurisprudence. ¶ A legal expert system called SHYSTER has been developed to demonstrate that a useful legal expert system can be based upon a pragmatic approach to the law. SHYSTER has a simple representation structure which simplifies the problem of knowledge acquisition. Yet this structure is complex enough for SHYSTER to produce useful advice. ¶ SHYSTER is a case-based legal expert system (although it has been designed so that it can be linked with a rule-based system to form a hybrid legal expert system). Its advice is based upon an examination of, and an argument about, the similarities and differences between cases. SHYSTER attempts to model the way in which lawyers argue with cases, but it does not attempt to model the way in which lawyers decide which cases to use in those arguments. Instead, it employs statistical techniques to quantify the similarity between cases. It decides which cases to use in argument, and what prediction it will make, on the basis of that similarity measure. ¶ SHYSTER is of a general design: it provides advice in areas of case law that have been specified by a legal expert using a specification language. Four different, and disparate, areas of law have been specified for SHYSTER, and its operation has been tested in each of those legal domains. ¶ Testing of SHYSTER in these four domains indicates that it is exceptionally good at predicting results, and fairly good at choosing cases with which to construct its arguments. SHYSTER demonstrates the viability of a pragmatic approach to legal expert system design.

<p>Om en pojke </p><p>- en pojke med Downs syndrom och kommunikationssvårigheters vardag</p><p>Uppsatsen handlar om hur den pojke som jag har valt att studera kommunicerar med sin omgivning när hans kommunikationssätt skiljer sig från det normala. Jag tar upp omgivningens inverkan och påverkan på kommunikationen och på livet i stort när förutsättningarna inte är samma som för övriga i gruppen. Pojken jag har studerat har Down syndrom och kraftig hörselnedsättning, han använder sig av teckenkommunikation och pictogrambilder för att kommunicera med sin omgivning. Jag har observerat pojken och intervjuat viktiga personer i hans närhet för att förstå hans livssituation. </p><p>Det samhälle vi lever i idag påverkar oss liksom hur tidigare samhällen har varit konstruerade. Synen på personer med funktionshinder har förändrats över tid och det har påverkat utformningarna av de olika system som finns i dag. Den kunskap och de erfarenheter vi har påverkar vårt sätt att bemöta våra medmänniskor. I det samhälle vi lever är vi separerade från varandra, vi känner bara till och förstår den grupp som vi själva tillhör. Samhället är strukturerat på ett vis där experter tar hand om många av våra existentiella frågor och funderingar, utan att vi för den sakens skull få svar på dem. Att vi i vår tid inte får tillgång till samma erfarenheter som samhällsmedborgare på medeltiden fick är naturligtvis en viktig aspekt som jag tar upp till diskussion och analys.</p>

Om en pojke - en pojke med Downs syndrom och kommunikationssvårigheters vardag Uppsatsen handlar om hur den pojke som jag har valt att studera kommunicerar med sin omgivning när hans kommunikationssätt skiljer sig från det normala. Jag tar upp omgivningens inverkan och påverkan på kommunikationen och på livet i stort när förutsättningarna inte är samma som för övriga i gruppen. Pojken jag har studerat har Down syndrom och kraftig hörselnedsättning, han använder sig av teckenkommunikation och pictogrambilder för att kommunicera med sin omgivning. Jag har observerat pojken och intervjuat viktiga personer i hans närhet för att förstå hans livssituation. Det samhälle vi lever i idag påverkar oss liksom hur tidigare samhällen har varit konstruerade. Synen på personer med funktionshinder har förändrats över tid och det har påverkat utformningarna av de olika system som finns i dag. Den kunskap och de erfarenheter vi har påverkar vårt sätt att bemöta våra medmänniskor. I det samhälle vi lever är vi separerade från varandra, vi känner bara till och förstår den grupp som vi själva tillhör. Samhället är strukturerat på ett vis där experter tar hand om många av våra existentiella frågor och funderingar, utan att vi för den sakens skull få svar på dem. Att vi i vår tid inte får tillgång till samma erfarenheter som samhällsmedborgare på medeltiden fick är naturligtvis en viktig aspekt som jag tar upp till diskussion och analys.

My research is about monitoring the software development process to assess Capability maturity level. Capability Maturity Model (CMM) was developed to improve the software process based on subjective assessment by teams of experts. We propose an objective CMM assessment, which replaces expensive and time-consuming human effort by a knowledge-based system. Compared to Subjective CMM assessment, Objective CMM assessment can be less expensive, takes less time, and is easy to estimate the software development environment maturity. The accuracy of Objective CMM assessment can be the same as Subjective CMM assessment if enough activities are represented as objective activities. For example, if subjective activities total 80 % and objective activities total 20 %, then the accuracy of Objective CMM assessment is not reliable. It would be reliable if the objective activity is increased up to 80% from 20%. This dissertation presents how to change from Subjective CMM assessment to Objective CMM assessment, and we will prove that Objective CMM Assessment is effective.

This dissertation has focused on automated power system fault analysis. New contributions to fault section estimation, protection system performance evaluation and power system/protection system interactive simulation have been achieved. Intelligent techniques including expert systems, fuzzy logic and Petri-nets, as well as data from remote terminal units (RTUs) of supervisory control and data acquisition (SCADA) systems, and digital protective relays have been explored and utilized to fufill the objectives. The task of fault section estimation is difficult when multiple faults, failures of protection devices, and false data are involved. A Fuzzy Reasoning Petri-nets approach has been proposed to tackle the complexities. In this approach, the fuzzy reasoning starting from protection system status data and ending with estimation of faulted power system section is formulated by Petri-nets. The reasoning process is implemented by matrix operations. Data from RTUs of SCADA systems and digital protective relays are used as inputs. Experiential tests have shown that the proposed approach is able to perform accurate fault section estimation under complex scenarios. The evaluation of protection system performance involves issues of data acquisition, prediction of expected operations, identification of unexpected operations and diagnosis of the reasons for unexpected operations. An automated protection system performance evaluation application has been developed to accomplish all the tasks. The application automatically retrieves relay files, processes relay file data, and performs rule-based analysis. Forward chaining reasoning is used for prediction of expected protection operation while backward chaining reasoning is used for diagnosis of unexpected protection operations. Lab tests have shown that the developed application has successfully performed relay performance analysis. The challenge of power system/protection system interactive simulation lies in modeling of sophisticated protection systems and interfacing the protection system model and power system network model seamlessly. An approach which utilizes the "compiled foreign model" mechanism of ATP MODELS language is proposed to model multifunctional digital protective relays in C++ language and seamlessly interface them to the power system network model. The developed simulation environment has been successfully used for the studies of fault section estimation and protection system performance evaluation.

No description available.

Thesis (M.Sc. (Computer Science))--North-West University, Potchefstroom Campus, 2010.