Structural analysis of surface and subsurface data from the Middle Magdalena Valley basin and Eastern Cordillera fold-thrust belt to construct a kinematic model for its Cenozoic structural and stratigraphic evolution. The La Salina west-vergent thrust system marks the boundary between the Paleogene foreland basin of the Middle Magdalena basin and the Eastern Cordillera fold-thrust belt. New low-temperature thermochonological and sandstone petrographic analyses provide constraints on ages of thrust deformation and sediment dispersal. Apatite fission track (AFT) and U-Th/He thermochronological results show the timing of three structural events along the La Salina fault system: (1) late Eocene-early Oligocene (~43–35 Ma) initial hanging wall exhumation; (2) continued middle Miocene (~15 Ma) exhumation; and (3) continued but more rapid late Miocene (~12–3 Ma) hanging wall exhumation. Vitrinite reflectance results provide estimates of maximum burial depths for the hanging wall of the La Salina fault ranging from 4 to 6 km., this depth of burial estimates constrain the basin geometry during its late Eocene to late Miocene evolution. The eastern hanging wall of the La Salina fault displays a broad anticline-syncline pair affecting Cretaceous to Eocene strata with no significant faulting, whereas the western footwall contains a complex series of tight, thrust-related folds in Eocene-Quaternary strata. For foreland basin province, a proposed triangle zone accommodates a small amount of east-west shortening (< 1000 m) along the frontal thrust system by east-vergent backthrusting within a broader passive-roof duplex. East-west shortening in the Cenozoic stratigraphic section was also accommodated by detachment folding, which produced localized areas of steep dips. In the proposed kinematic restoration, the most recent phase of deformation represents out-of-sequence reactivation of the La Salina fault that is consistent with irregular crosscutting relationships of some footwall structures. Earliest exhumation by ~45–30 Ma in the Eastern Cordillera fold-thrust belt province matches (1) an increased proportion of sedimentary lithic fragments; and (2) a high degree of compositional maturity (Q88F4Lf8). Exhumation since ~15 Ma in the foreland province coincides with (1) the highest accumulation rates observed for the upper Miocene Real Group; and (2) a decrease in compositional maturity (Q55F8Lf36). / text

Alkalic porphyry style Au-Cu deposits of the Cadia district are associated with Late-Ordovician monzonite intrusions, which were emplaced during the final phase of Macquarie Arc magmatism at the end of the Benambran Orogeny. N-striking faults, including the curviplanar, northerly striking, moderately west-dipping basement thrust faults of the Cadiangullong system, developed early in the district history. NE-striking faults formed during rifting in the late Silurian. Subsequent E-W directed Siluro- Devonian extension followed by regional E-W shortening during the Devonian Tabberabberan Orogeny dismembered these intrusions, thereby superposing different levels porphyry Au-Cu systems as well as the host stratigraphy. During the late Silurian, the partially exhumed porphyry systems were buried beneath the Waugoola Group sedimentary cover sequence, which is generally preserved in the footwall of the Cadiangullong thrust fault system. The Waugoola Group is a typical rift-sag sequence, deposited initially in local fault-bounded basins which then transitioned to a gradually shallowing marine environment as local topography was overwhelmed. Basin geometry was controlled by pre-existing basement structures, which were subsequently inverted during the Devonian Tabberabberan Orogeny, offsetting the unconformity by up to 300m vertically. In the Waugoola Group cover, this shortening was accommodated via a complex network of minor detachments that strike parallel to major underlying basement faults. For this reason, faults and folds measured at the surface in the sedimentary cover can be used as a predictive tool to infer basement structures at depth.

La technologie des microarrays demeure à ce jour un outil important pour la mesure de l'expression génique. Au-delà de la technologie elle-même, l'analyse des données provenant des microarrays constitue un problème statistique complexe, ce qui explique la myriade de méthodes proposées pour le pré-traitement et en particulier, l'analyse de l'expression différentielle. Toutefois, l'absence de données de calibration ou de méthodologie de comparaison appropriée a empêché l'émergence d'un consensus quant aux méthodes d'analyse optimales. En conséquence, la décision de l'analyste de choisir telle méthode plutôt qu'une autre se fera la plupart du temps de façon subjective, en se basant par exemple sur la facilité d'utilisation, l'accès au logiciel ou la popularité. Ce mémoire présente une approche nouvelle au problème de la comparaison des méthodes d'analyse de l'expression différentielle. Plus de 800 pipelines d'analyse sont appliqués à plus d'une centaine d'expériences sur deux plateformes Affymetrix différentes. La performance de chacun des pipelines est évaluée en calculant le niveau moyen de co-régulation par l'entremise de scores d'enrichissements pour différentes collections de signatures moléculaires. L'approche comparative proposée repose donc sur un ensemble varié de données biologiques pertinentes, ne confond pas la reproductibilité avec l'exactitude et peut facilement être appliquée à de nouvelles méthodes. Parmi les méthodes testées, la supériorité de la sommarisation FARMS et de la statistique de l'expression différentielle TREAT est sans équivoque. De plus, les résultats obtenus quant à la statistique d'expression différentielle corroborent les conclusions d'autres études récentes à propos de l'importance de prendre en compte la grandeur du changement en plus de sa significativité statistique. / Microarrays remain an important tool for the measurement of gene expression, and a myriad of methods for their pre-processing or statistical testing of differential expression has been proposed in the past. However, insufficient and sometimes contradictory evidence has prevented the emergence of a strong consensus over a preferred methodology. This leaves microarray practitioners to somewhat arbitrarily decide which method should be used to analyze their data. Here we present a novel approach to the problem of comparing methods for the identification of differentially expressed genes. Over eight hundred analytic pipelines were applied to more than a hundred independent microarray experiments. The accuracy of each analytic pipeline was assessed by measuring the average level of co-regulation uncovered across all data sets. This analysis thus relies on a varied set of biologically relevant data, does not confound reproducibility for accuracy and can easily be extended to future analytic pipelines. This procedure identified FARMS summarization and the TREAT gene ordering statistic as algorithms significantly more accurate than other alternatives. Most interestingly, our results corroborate recent findings about the importance of taking the magnitude of change into account along with an assessment of statistical significance.

Darbo uždaviniai buvo: Nustatyti gerklų audinio MMP-2 ir MMP-9 raiškos pokyčius kai yra nepiktybiniai gerklų dariniai (balso klosčių polipai), ikivėžinė gerklų patologija (atsinaujinanti gerklų papilomatozė ir lėtinis hiperplazinis laringitas su keratoze) bei gerklų plokščių ląstelių karcinoma ir įvertinti šių pokyčių diagnozinę vertę. Įvertinti gerklų audinio MMP-2 ir MMP-9 raiškos pokyčių sąsajas su klinikiniais ir morfologiniais nepiktybinių gerklų darinių (balso klosčių polipai), ikivėžinės gerklų patologijos (atsinaujinanti gerklų papilomatozė ir lėtinis hiperplazinis laringitas su keratoze) bei gerklų plokščių ląstelių karcinomos požymiais. Palyginti matrikso metaloproteinazes koduojančių genų MMP-2 (-735 C/T), MMP-2 (-1306 C/T), MMP-9 (-1562 C/T) ir MMP-3 (-1171 5A/6A) polimorfizmo dažnį, kai yra organinės nepiktybinės gerklų ligos bei gerklų plokščių ląstelių karcinoma. Įvertinti matrikso metaloproteinazes koduojančių genų MMP-2 (-735 C/T), MMP-2 (-1306 C/T), MMP-9 (-1562 C/T) ir MMP-3 (-1171 5A/6A) polimorfizmo sąsajas su gerklų plokščių ląstelių karcinoma bei jos klinikiniais ir morfologiniais požymiais. / The goals of the study were as follows: 1. To determine the changes in the expression of the laryngeal tissues MMP-2 and MMP-9 in patients with benign laryngeal tumors (vocal fold polyps), precancerous laryngeal lesions (recurrent respiratory papillomatosis and laryngeal keratosis) and laryngeal squamous cell carcinoma, and assess the diagnostic value of the aforementioned changes. 2. To assess the correlations between the changes in the expression of the laryngeal tissues MMP-2 and MMP-9 and the clinical and morphologic indications of benign laryngeal tumors (vocal fold polyps), precancerous laryngeal lesions (recurrent respiratory papillomatosis and laryngeal keratosis) and laryngeal squamous cell carcinoma. 3. To compare the rate of MMP-2 (-735 C/T), MMP-2 (-1306 C/T), MMP-9 (-1562 C/T) and MMP-3 (-1171 5A/6A) gene polymorphism in cases of non-malignant laryngeal lesions and laryngeal squamous cell carcinoma. 4. To assess the association between MMP-2 (-735 C/T), MMP-2 (-1306 C/T), MMP-9 (-1562 C/T) and MMP-3 (-1171 5A/6A) gene polymorphism, the laryngeal squamous cell carcinoma as well as its clinical and morphologic indications.

Alkalic porphyry style Au-Cu deposits of the Cadia district are associated with Late-Ordovician monzonite intrusions, which were emplaced during the final phase of Macquarie Arc magmatism at the end of the Benambran Orogeny. N-striking faults, including the curviplanar, northerly striking, moderately west-dipping basement thrust faults of the Cadiangullong system, developed early in the district history. NE-striking faults formed during rifting in the late Silurian. Subsequent E-W directed Siluro- Devonian extension followed by regional E-W shortening during the Devonian Tabberabberan Orogeny dismembered these intrusions, thereby superposing different levels porphyry Au-Cu systems as well as the host stratigraphy. During the late Silurian, the partially exhumed porphyry systems were buried beneath the Waugoola Group sedimentary cover sequence, which is generally preserved in the footwall of the Cadiangullong thrust fault system. The Waugoola Group is a typical rift-sag sequence, deposited initially in local fault-bounded basins which then transitioned to a gradually shallowing marine environment as local topography was overwhelmed. Basin geometry was controlled by pre-existing basement structures, which were subsequently inverted during the Devonian Tabberabberan Orogeny, offsetting the unconformity by up to 300m vertically. In the Waugoola Group cover, this shortening was accommodated via a complex network of minor detachments that strike parallel to major underlying basement faults. For this reason, faults and folds measured at the surface in the sedimentary cover can be used as a predictive tool to infer basement structures at depth.

Abstract The Late Devonian-Early Carboniferous Drummond Basin of central Queensland, Australia is one of the oldest units of the New England Fold Belt. Samples of authigenic clay minerals have been collected from across the Drummond Basin and analysed using mineralogic, isotopic and geochronologic techniques. X-Ray diffraction analysis on 36 samples selected from six exploration wells was carried out on volcaniclastic and argillaceous sandstones and mudstones of the Drummond Basin sequence in order to ascertain authigenic illite content. Sixteen samples were found to be suitable for K-Ar dating purposes, containing abundant illite and illite/smectite mixed layers (I/S). K-Ar age dating was carried out on these selected samples yielding three age groups at 300, 250 and 200 Ma. Temperature of formation was estimated for the authigenic illite and illite/smectite minerals, based on illite crystallinity and illite content of illite/smectite mixed layers. Two groups of temperatures have been delineated, with a high temperature assemblage of between 275¨¬C-320¨¬C and a low temperature assemblage of approximately 100¨¬C. When compared with the age groups, it is seen that the older event was typically hotter. Stable isotope compositions for the authigenic clay minerals were analysed with ¥äD and ¥ä18O values of between -68¢¶ to -117¢¶ and +7.5¢¶ to +14.4¢¶ (SMOW) respectively. Isotopic compositions for the fluid in equilibrium with the clay minerals were calculated using palaeotemperatures estimated from the clay mineralogy and range between -90¢¶ and -41¢¶ and -0.6¢¶ and +8.7¢¶ (SMOW) for hydrogen and oxygen respectively. These compositions are more depleted in deuterium and more enriched in 18O than those previously reported for basins in the region. The data also produced three groups of fluid compositions, which correlate with the age distributions delineated by the K-Ar geochronology. The first fluid composition, which correlated with the Permo-Carboniferous age (~300 Ma) is interpreted to result from a mixing of Permo-Carboniferous meteoric water with highly evolved formation water trapped within the Drummond Basin since deposition of the basin. The regional extensional event at the Permo-Carboniferous boundary, which initiated the opening of the Bowen Basin to the east of the Drummond Basin allowed meteoric water to percolate deep into the basin, enabling the growth of illite rich clay minerals at this time. The second fluid group is considered to represent the evolution of Late Triassic meteoric water migrating through the Drummond Basin during another extensional period in the region at approximately 200 Ma. This event precipitated a new period of clay mineral growth in the basin (reflected in the K-Ar dates), raised the geothermal gradient in the region and extended the crust, forming new sedimentary basins within the New England Fold Belt. The third assemblage of fluid compositions were found to be very similar to the Late Triassic group, with ¥äD and ¥ä18O values plotting very close to the Late Triassic meteoric water evolution trend. This is interpreted as representing the same fluid as that which produced the Late Triassic compositions and therefore the 250 Ma ages may represent partial resetting of older ages by the Late Triassic thermal episode. However, if it is assumed that these K-Ar ages are not old ages partially reset by a thermal event, the stable isotope data could represent a mixing of Mid-Late Permian meteoric water with formation water trapped in the basin. This event may represent the regional compressive Hunter-Bowen event and may be responsible for dewatering the basin before the Late Triassic extensional episode.

Orientador: Antonio José Maria Cataneo / Resumo: Introdução: A paralisia de pregas vocais caracteriza-se como uma das principais complicações e sequelas após a tireoidectomia. A técnica convencional compreende a identificação visual do trajeto do nervo para sua preservação e a neuromonitorização do nervo laríngeo recorrente (NLR) durante a cirurgia de tireóide visa a redução do risco de paralisias por injúria ao NLR, porém sua utilidade ainda é discutível. Objetivos: Determinar através de revisão sistemática se o uso da neuromonitorização do NLR durante tireoidectomias realmente apresenta benefícios comparado á técnica convencional de identificação somente do nervo durante a cirurgia, especialmente em termos de redução do risco de paralisia de prega vocal, seja transitória ou permanente. Materiais e Métodos: A pesquisa nas principais bases de dados, MEDLINE via PUBMED, LILACS, SCOPUS, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL); clinicaltrials.gov e fontes adicionais foi realizada em Maio de 2018. Uma revisão sistemática e meta-análise foram feitas usando o modelo de efeitos fixos. O GRADE foi usado para classificar a qualidade das evidências. Os desfechos primários avaliados foram o total de paralisias do NLR por nervos em risco, paralisias transitórias e permanentes e o tempo de cirurgia comparando-se as duas técnicas. Como desfechos secundário avaliou-se o tempo de cirurgia. Foi realizada análise de subgrupos de pacientes de alto e baixo risco de injuria do NLR. Também avaliamos como análise de subgr... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Introduction: Vocal cord paralysis is characterized as one of the main complications and sequels after thyroidectomy. The conventional technique comprises the visual identification of the nerve path for its preservation and recurrent laryngeal nerve (RLN) neuromonitoring during thyroid surgery aims to reduce the risk of paralysis due to injury to the RLN, but its usefulness is still debatable. Objectives: To determine through systematic review if the use of neuromonitoring of the RLN during thyroidectomies actually presents benefits compared to the conventional technique of only identification of the nerve during surgery, especially in terms of reducing the risk of vocal fold paralysis, whether transient or permanent. Materials and Methods: The search in the main databases, MEDLINE, LILACS, SCOPUS, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL); clinicaltrials.gov and additional sources was performed in May 2018. A systematic review and meta-analysis was done using the fixed-effects model. GRADE was used to classify the quality of the evidence. The primary endpoints evaluated were the total nerve paralysis for nerves at risk, transient and permanent paralyzes, and surgery time comparing the two techniques. As secondary outcomes, the time of surgery was evaluated. We also evaluated as subgroup analysis the transient and permanent paralysis in a group of patients with high and low risk of RLN injury. Results: Four randomized clinical trials involving 1.379 pat... (Complete abstract click electronic access below) / Mestre

Submitted by TAMIRES FERREIRA SIQUEIRA (tamy_170@yahoo.com.br) on 2018-08-03T16:10:50Z No. of bitstreams: 1 Tese Mestrado Tamires.1.pdf: 1168639 bytes, checksum: b2029c52ab3322c660f0abd08f81dd9e (MD5) / Approved for entry into archive by Sulamita Selma C Colnago null (sulamita@btu.unesp.br) on 2018-08-06T13:19:27Z (GMT) No. of bitstreams: 1 siqueira_tm_me_bot.pdf: 1168639 bytes, checksum: b2029c52ab3322c660f0abd08f81dd9e (MD5) / Made available in DSpace on 2018-08-06T13:19:27Z (GMT). No. of bitstreams: 1 siqueira_tm_me_bot.pdf: 1168639 bytes, checksum: b2029c52ab3322c660f0abd08f81dd9e (MD5) Previous issue date: 2018-07-12 / Introdução: A paralisia de pregas vocais caracteriza-se como uma das principais complicações e sequelas após a tireoidectomia. A técnica convencional compreende a identificação visual do trajeto do nervo para sua preservação e a neuromonitorização do nervo laríngeo recorrente (NLR) durante a cirurgia de tireóide visa a redução do risco de paralisias por injúria ao NLR, porém sua utilidade ainda é discutível. Objetivos: Determinar através de revisão sistemática se o uso da neuromonitorização do NLR durante tireoidectomias realmente apresenta benefícios comparado á técnica convencional de identificação somente do nervo durante a cirurgia, especialmente em termos de redução do risco de paralisia de prega vocal, seja transitória ou permanente. Materiais e Métodos: A pesquisa nas principais bases de dados, MEDLINE via PUBMED, LILACS, SCOPUS, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL); clinicaltrials.gov e fontes adicionais foi realizada em Maio de 2018. Uma revisão sistemática e meta-análise foram feitas usando o modelo de efeitos fixos. O GRADE foi usado para classificar a qualidade das evidências. Os desfechos primários avaliados foram o total de paralisias do NLR por nervos em risco, paralisias transitórias e permanentes e o tempo de cirurgia comparando-se as duas técnicas. Como desfechos secundário avaliou-se o tempo de cirurgia. Foi realizada análise de subgrupos de pacientes de alto e baixo risco de injuria do NLR. Também avaliamos como análise de subgrupos as paralisias transitórias e permanentes em grupo de pacientes de alto e baixo risco de injúria do NLR. Resultados: Quatro ensaios clínicos randomizados envolvendo 1.379 pacientes submetidos à tireoidectomia utilizando a neuromonitorização ou com a identificação somente do NLR, sendo 2.605 o número total de nervos em risco foram avaliados. A neuromonitorização diminuiu o risco do total paralisias (transitórias e permanentes) de prega vocal em tireoidectomias (RR 0,64; IC 95% de 0,43 a 0,95, I 2 = 30%), assim como diminuiu o risco de paralisias transitórias (RR 0,60; IC 95% de 0,38 a 0,95, I 2 =10%), porém não diminuiu o risco de paralisias permanentes (RR 0,84; IC 95% de 0,36 a 1,93, I 2 = 0%). A análise da média do tempo de cirurgia foi conduzida em dois estudos, entretanto como a heterogeneidade entre os estudos foi maior que 75% a metanálise não foi apropriada para estabelecer a diferença do tempo médio de cirurgia entre os grupos. Quanto a análise de subgrupos, observou-se que a neuromonitorização não diminuiu o risco de paralisias transitórias (RR 0,61; IC 95% de 0,28 a 1,31, I 2 = 0%) e nem o risco de paralisias permanentes de prega vocal em tireoidectomias de baixo risco (RR 1,03; IC 95% de 0,21 a 5,07, I 2 não aplicável). Assim como também não diminuiu o risco de paralisias transitórias (RR 0,75; IC 95% de 0,18 a 3,07, I 2 = 71%) e de paralisias permanentes de prega vocal em tireoidectomias de alto risco (RR 0,69; IC 95% de 0,27 a 1,79, I 2 = 4%). Conclusões: Essa meta-análise utilizando apenas ensaios clínicos randomizados demonstrou que a neuromonitorização do nervo laríngeo recorrente em tireoidectomias possivelmente reduz ligeiramente o risco de paralisia transitória das pregas vocais, mas provavelmente faz pouca ou nenhuma diferença no risco de paralisia permanente. / Introduction: Vocal cord paralysis is characterized as one of the main complications and sequels after thyroidectomy. The conventional technique comprises the visual identification of the nerve path for its preservation and recurrent laryngeal nerve (RLN) neuromonitoring during thyroid surgery aims to reduce the risk of paralysis due to injury to the RLN, but its usefulness is still debatable. Objectives: To determine through systematic review if the use of neuromonitoring of the RLN during thyroidectomies actually presents benefits compared to the conventional technique of only identification of the nerve during surgery, especially in terms of reducing the risk of vocal fold paralysis, whether transient or permanent. Materials and Methods: The search in the main databases, MEDLINE, LILACS, SCOPUS, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL); clinicaltrials.gov and additional sources was performed in May 2018. A systematic review and meta-analysis was done using the fixed-effects model. GRADE was used to classify the quality of the evidence. The primary endpoints evaluated were the total nerve paralysis for nerves at risk, transient and permanent paralyzes, and surgery time comparing the two techniques. As secondary outcomes, the time of surgery was evaluated. We also evaluated as subgroup analysis the transient and permanent paralysis in a group of patients with high and low risk of RLN injury. Results: Four randomized clinical trials involving 1.379 patients undergoing thyroidectomy using neuromonitoring or with identification only of the RLN, of which 2.605 was the total number of nerves at risk evaluated. Neuromonitoring reduced the risk of total (transient and permanent) vocal fold paralysis after thyroidectomies (RR 0.64, 95% CI 0.93 to 0.95, I 2 = 30%), as well as decreased the risk of transient paralysis (RR 0.60, 95% CI 0.38 to 0.95, I 2 = 10%), but did not decrease the risk of permanent paralysis (RR 0.84, 95% CI 0.36 to 1.93, I2 = 0%). The analysis of the mean time of surgery was conducted in two studies, however, the heterogeneity between the studies was greater than 75% and the meta-analysis was not appropriate to establish the difference in the mean time of surgery between the groups. As the analysis of subgroups, it was observed that neuromonitoring did not reduce the risk of transient paralysis (RR 0.61, 95% CI 0.28 to 1.31, I 2 = 0%) and neither the risk of permanent paralysis in low-risk thyroidectomies (RR 1.03, 95% CI 0.21 to 5.07, I2 not applicable). As it also did not reduce the risk of transient paralysis (RR 0.75, 95% CI 0.18 to 3.07, I2 = 71%) and permanent vocal fold paralysis in high-risk thyroidectomies (RR 0, 69, 95% CI 0.27 to 1.79, I 2 = 4%). Conclusions: This meta-analysis using only randomized clinical trials has demonstrated that recurrent laryngeal nerve neuromonitoring in thyroidectomies possibly slightly reduces the risk of transient vocal fold paralysis but probably makes little or no difference in the risk of permanent paralysis.

xvi, 121 p. : ill. (some col.), maps (some col.) Also includes two large-scale maps in two separate pdf files. A print copy of this thesis is available through the UO Libraries. Search the library catalog for the location and call number. / Deformation across plate boundaries often occurs over broad zones with relative motions between plates typically accommodated by faults of different styles acting together in a complex system. Collision of the Yakutat microplate within the Alaskan portion of the Pacific-North America plate boundary drives deformation over 600 km away where the Denali fault divides predominantly rigid crustal block motions of southern Alaska from distributed deformation in central Alaska. Quaternary geologic mapping along the Nenana River valley and the Japan Hills of the northern foothills of the Alaska Range defines zones of Quaternary thrust faulting recorded in the progressive deformation of Pleistocene fluvial terraces. I use topographic profiles of these terraces and paleoseismic trenching of fault scarps to characterize the Quaternary activity and constrain the subsurface geometry of these faults. Radiocarbon and cosmogenic exposure dating methods provide age control on the stratigraphy in the trenches and landforms offset by these faults. These observations define a 1-1.5 mm/yr slip rate for the Gold King fault which changes laterally from a north-vergent thrust into a north and south vergent thrust wedge that uplifts the Japan Hills. Along the Nenana River valley, the progressive deformation of Pleistocene surfaces defines a north-vergent critically-tapered thrust wedge. The geometry of progressive uplift and folding requires a near planar, south-dipping basal thrust fault with two major north-dipping backthrusts. All three faults were active simultaneously on a scale of 10 4 yrs with slip rates of 0.25-1 mm/yr, until the late Pleistocene when we infer the retreat of glacial ice from the main axis of the Alaska Range caused a change in thrust wedge dynamics. I use the orientation of Quaternary deformation north of the Denali fault to show that strain is highly partitioned and establish geologic constraints on the regional horizontal stress orientation. North of the Denali fault, fault-normal principal shortening accommodates 3-5 mm/yr of strain transfer across the Denali fault system. Two appendices contain additional results of paleoseismic trenching and neotectonic investigations across 4 active faults near the Nenana River. This dissertation includes previously unpublished co-authored material. / Committee in charge: Ray Weldon, Chairperson, Geological Sciences; Joshua Roering, Member, Geological Sciences; David Schmidt, Member, Geological Sciences; Douglas Kennett, Outside Member, Anthropology

Made available in DSpace on 2016-08-03T12:19:54Z (GMT). No. of bitstreams: 1 vitor souza2.pdf: 2101245 bytes, checksum: 214591feb6d6907cb11972a37f74bb2d (MD5) Previous issue date: 2015-03-16 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / This research intends to demonstrate the theme of religion in the thought of Paul Ricoeur. It correlates philosophy and theology having in the question of God the main problem. The hypothesis of the thesis argues that the intersection of the ar-eas is productive and an original work of thought can arises from this cross. The thesis suggests the term of the fold of religion, considering the task of recogni-tion of the self within broken ontology. The reflective philosophy articulates the aporias with the ontology of the possible in existential categories, especially in terms of religious language, hope and the aporia of grace. The research utilizes the phenomenological and hermeneutical method, and it is divided into four stages: at first, introduces the relationship between philosophy and theology and the divine name as the first fold of religion. The second chapter deals with time, narrative, and the myth-poetic. The third chapter deals with the metaphorical in-terpretation of religion within the ontology of the possible. The fourth and final chapter presents the existential fold whose movement is as a philosophical spiral in the life of Ricoeur. The research is concluded on the horizon of the capable human being and the recognition of the self mediated by the fold of religion. The result will be a reflection that makes possible a better understanding of the philosophy of Ricoeur, as well as foundation for future studies on the philoso-phy of religion. / Esta pesquisa propõe-se a tematizar a religião no pensamento de Paul Ricoeur. Correlaciona filosofia e teologia e tem na nomeação de Deus o primeiro pro-blema. Ao analisar os limites do assunto, a hipótese da tese sustenta que a inter-secção das áreas é produtiva e que um trabalho original de pensamento pode vir deste cruzamento. A tese sugere o termo da dobra da religião, tendo em vista a apropriação da tarefa do reconhecimento do si na ontologia quebrada. O desdo-bramento das aporias, pela filosofia reflexiva, articula a ontologia do possível nas categorias existenciais do autor, sobretudo em termos da linguagem religio-sa, da esperança e da aporia da graça. A pesquisa é feita com base no método fenomenológico e hermenêutico, dividido em quatro etapas: num primeiro mo-mento, introduz-se a relação da filosofia com a teologia e o teônimo como a primeira dobra da religião. No segundo capítulo, aborda-se a importância tempo-ralidade e a narratividade na mito-poética. O terceiro capítulo versa sobre a in-terpretação metafórica da religião na ontologia do possível. O quarto e último capítulo apresenta a dobra existencial cujo movimento se dá como um espiral fi-losófico na própria vida de Ricoeur. A pesquisa é concluída no horizonte do ser humano capaz e o reconhecimento de si mediado pela dobra da religião. Espera-se que o resultado seja uma reflexão que permita uma melhor compreensão da filosofia de Ricoeur, bem como que sirva de referencial e fundamento para fu-turos estudos acerca da filosofia da religião.