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Two dopaminergic altering drugs, haloperidol and carbidopa + levodopa, and juice only conditions, were given to six squirrel monkeys in factorial combination with two novel environments and an alone condition. The point of this research was to assess differences in subjects' adaptation to various stimulus conditions under the differential influence of the two drug conditions. Control conditions for both drug and environmental variables were included in the design, which provided a baseline for comparison with active variables. Although no significant interactions between drugs and environments were found, some interesting reactions to the non-drug-laced vehicle were noted. The drugs, haloperidol and carbidopa-levodopa, have been used in many past comparative studies. However, the thrust of most research has been focused upon changes in movement capability, or deterioration of movement ability. Extrapyramidal side-effects, such as bizarre facial and tongue movement and postural changes, have generally been included in these investigations. Little attention has been placed upon adaptive change to novel environments, which may occur with these drugs. This research represents an initial investigation of such changes, an important consideration in view of their widespread use as therapeutic agents with humans.

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Inaug.-Diss.--Universität Erlangen-Nürnberg, Nürnberg. / Vita.

A desire to study congenital malformations of the CNS originated several years ago. It was found necessary first to acquire sufficient knowledge of anatomy of the normal adult human brain as well as of the morphogenesis of the developing human brain. The results of the work done in this field formed the subject for my M.Sc. thesis at the McGill University: Anatomical and Developmental Study of the Human Thalamus, 1951. This was subsequently published in the J. Comp. Neurology 1953 and 1954.

Many methods of gradually occluding blood vessels have been developed over the past Century. Some of these methods have withstood the effects of trial in time, and are still in use for clinical and experimental purposes. However, all of these methods have drawbacks of one sort or another. At present, there is need for a more efficient and less cumbersome means of occluding certain arteries for investigative and clinical purposes. One need has arisen from the desire to reproduce as realistically as possible many ominous disease states which result from aging and catastrophic vascular events.