Controversy remains about the contribution of hypoglycemia to brain damage in the newborn. Therefore, the objective of this study was to determine the effects of isolated hypoglycemia on damage to the immature rat brain. Seven-day-old rats, equivalent to a late preterm human newborn, were placed in either Sham or hypoglycemic groups. Hypoglycemia was induced by insulin infusion for variable periods of time. Outcomes were assessed by behavioral, neurochemical and neuropathologic determination. Rats were categorized as having mild, moderate, or severe hypoglycemia. Behavioral tests revealed no abnormality in hypoglycemic animals. Floro-JadeB showed significant damage in the thalamic reticular nucleus (TRN) of the severe hypoglycemic animals at PD9. However, neuronal (Neu-N), astrocytic (GFAP), and myelin (MBP) staining at PD21 showed no brain injury. There was a significant rise in aspartate and arginine, and drop in glutamine and alanine of hypoglycemic brains. Oxidative stress markers were also increased in hypoglycemic brains. We conclude that isolated prolonged severe hypoglycemia caused a transient, region specific increase in neuronal cell death within the TRN. Though transient in nature, the associated neurochemical alterations warrant further research to determine if more subtle long-term effects may result.

Purpose: The purpose of this study was three-fold; to investigate the use of pain assessment tools and pain reduction strategies during minor painful procedures in neonatal units in Australia; to map the history of an infant’s prolonged hospitalisation in a tertiary neonatal intensive care unit with respect to painful procedures and pain management practices, and to describe the effectiveness of oral sucrose in reducing procedural pain during the course of an infant’s prolonged hospitalisation (greater than/equal to 28 days). (For complete abstract open document)

Thesis (M.M.) -- Florida State University, 2004. / Advisor: Jayne Standley, Florida State University, School of Music. Title and description from thesis home page (viewed 9-24-04). Document formatted into pages; contains 30 pages. Includes biographical sketch. Includes bibliographical references.

Thesis (M.D. 1972) from the Dept. of Child Health, University of Adelaide.

Thesis (M.S.P.H.)--University of Michigan, 1941.

The authors' Thesis (Ph. D.)--Ohio State University: Pratt, 1927; Nelson, 1928; Sun, 1928. / Autobiographies. Issued also as Ohio State University studies, Contributions in psychology, no. 10. This issue is identical except for different cover and the addition of the autobiographies. Bibliography: p. 213-234.

Thesis (M.S.P.H.)--University of Michigan, 1941.

Thesis (M.S.)--University of Wisconsin--Madison. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 57-58).

Thesis (M.Med.Sc.)--University of Hong Kong, 2002. / Includes bibliographical references (leaves 74-83) Also available in print.

Thesis (M.A.)--University of Delaware, 2008. / Principal faculty advisor: Karen Rosenberg, Dept. of Anthropology. Includes bibliographical references.