South Africa is currently an emerging economy and has various trade agreements with the United States of America and the United Kingdom according to which South Africa enjoys different preferential rules of origin. In some respects, current customs and excise legislation relating to rules of origin places South Africa at a disadvantage in the global arena. In some cases, preferential rules of origin with developed countries benefit South Africa little if they are not properly structured, or if the rules of various trade agreements contradict each other. The aim of this study was to ascertain whether South Africa’s rules of origin are sufficiently aligned with those of more developed economies to improve the economy, thereby increasing trade growth and tax revenue. This study compared the South African rules of origin with rules of origin that are applied in another developing country, namely Brazil, as well as to those applied in two developed countries, namely the United Kingdom and the United States. To illustrate the application of the rules of origin, this study focused specifically on rules of origin applicable to individual quick frozen poultry. This comparative study identified similarities and differences between the countries, and noted possible improvements to South African customs and excise tax legislation for this industry. It was found that the rules of origin applied in South Africa are similar in some respects to those used in the UK. An improvement that South Africa could make is to minimise the number of rules in effect by negotiating better preferential rates of duty across more than one country. South Africa could also ensure that it can comply with all obligatory conditions of trade agreements entered into to avoid under-utilisation of the benefits of a trade agreement. By adopting or adapting some of the advantages of the rules of origin in the countries chosen for comparison, South Africa can grow its international trade and generate increased tax revenue to support the government’s revenue income demand. / Dissertation (MCom)--University of Pretoria, 2014. / tm2015 / Taxation / MCom / Unrestricted

BACKGROUND A great interest of researchers has been attracted to the phenomenon of country-of-origin (Andéhn et al., 2016). It is argued that companies could increase competitiveness in the market by implementing a COO into the company's branding strategy (Guercini & Ranfagni, 2013). However, prior research on COO has been focused mainly on the investigation of customer perspective, while the producer's (e.g.firm) perspective was not taken into account (Brodie & Benson-Rea, 2016). Thus, the understanding of COO branding has to be expanded. Furthermore, the use of a COO can not be managed as independent marketing activity (Bhaskaran & Sukumaran, 2007) and has to be rationally implemented into the brand (Brodie & Benson-Rea, 2016). This creates a gap in the knowledge of how firms manage the use of a COO and how the COO is implemented into the company's brand identity. This gap can be addressed by evaluating the producer's perspective and the COO's impact on the brand identity and branding strategies. PURPOSE The aim of this study is to extend the understanding of the impact of the COO on the brand identity of Swedish SMEs. Additionally, to investigate the use of Sweden in branding. METHOD To fulfill the purpose of the study, exploratory qualitative research is executed, employing a multiple-case study design where nine cases were selected to develop an in-depth understanding of the research topic. CONCLUSION Based on the research, the COO has a strong impact on the brand identity of Swedish SMEs. As it can be seen from the empirical data, the brand identity of Swedish SMEs is impacted by the COO in terms of personality, physique, and culture dimensions on the key characteristics of the origin. Additionally, the COO is implemented into the Swedish SMEs branding through nine strategies.

Thanks to the wide range of features offered by the World Wide Web (WWW), many web applications have been published and developed through different libraries and programming languages. Adapting to new changes, the Web quickly evolved into a complex ecosystem, introducing many security problems to its users. To solve these problems, instead of re-designing the Web, the vendors added the security patches (protocols, mechanisms)to the Web platform to provide a more convenient and more secure environment for web users. However, not only did these patches not completely resolve the security problems, but their implementations also introduced other security risks unbeknownst to website operators and users. In this thesis, I propose a novel research on two different security patches to understand and analyze their deployment in real-world scenarios and discover the unseen, neglected factors and the elements involved in exploiting their use: one security protocol, OAuth, and one security mechanism, CORS. As this thesis is based on offensive approaches, I develop automated methodologies, including novel strategies for analyzing and measuring the security qualities of the OAuth protocol and CORS mechanism in real-world scenarios.

The origin of the 0 -methyl and the N -methyl group in the alkaloid ricinine has been determined. Carbon 14 labelled sodium bicarbonate sodium formate and C14 methyl labelled L-methionine and choline were administered to growing seedlings of Ricinus communis which elaborate the alkaloid ricinine. Methionine was the only metabolite that produced C14 activity in the alkaloid. The activity was located entirely in the methyl groups and the specific activity of the O-methyl and N-methyl group was found, within experimental error, to be identical. / Thesis / Master of Science (MSc)

Syfte: Syftet med denna studie är att undersöka vilka effekter COO har på svenska konsumenter gällande varumärken och produkter med ursprung från Kina.  Metod: Studien har utgått från en deduktiv process med en kvantitativ metod. Dock använder studien inte hypoteser utan istället en frågeställning för att ha möjligheten att analysera resultaten mer fritt. Data har samlats in genom en webbaserad enkät som publicerades på sociala kanaler. Totalt kom 112 svar in varav 4 resulterade i bortfall, vilket till följd gav 108 användbara svar. Datan analyserades genom att utföra en korrelationsanalys samt en deskriptiv analys genom statistikprogrammet Jamovi. Resultat och slutsats: Undersökningen indikerar att svenska konsumenters köpbeteende i hög grad påverkas av ursprungslandseffekter (Country-of-origin effects, förkortat COO). Effekterna av COO visade sig vara särskilt stora vid utvärdering av kinesiska produkter, där svenska konsumenter visade sig ha en tydlig negativ uppfattning av produkter med detta ursprung. Detta gällde i synnerhet för den undersökta produktkategorin bilar där få konsumenter kunde tänka sig att köpa en kinesisk bil jämfört med andra ursprung. Trots detta rankade svenska konsumenter ursprung betydligt lägre än andra attribut vid köp, vilket tyder på att effekterna av COO vid bilköp underskattades av svenska konsumenter.  Examensarbetets bidrag: Denna studie bidrar med kunskap om hur COO påverkar svenska konsumenter vid bilköp, samt hur svenska konsumenter uppfattar kinesiska produkter. Den bidrar även med information om hur svenska konsumenter rankar olika attribut vid bilköp. / Aim: The purpose of this study is to examine the Country-of-origin effects on Swedish consumers regarding Chinese brands and products Method: The study is based on a deductive process that uses a quantitative method. The study does not use hypotheses, instead a research question was concluded. This choice was made to have the opportunity to analyze the results more freely. Data was collected through a web-based survey that was published on social channels. A total of 112 responses were received, of which 4 resulted in non-response and 108 usable. The data was analyzed by performing a correlational- and descriptive analysis through the statistical program Jamovi. Result & Conclusions: The results from the study indicates that Swedish consumers purchasing behavior is greatly influenced by the country-of-origin effect. The country-oforigin effect was found to be particularly large when evaluating Chinese products. Swedish consumers were found to have a negative perception of products with this origin. This was particularly true for the investigated product category, where few consumers could imagine themselves buying a Chinese car compared to other origins. Despite this, Swedish consumers ranked origin lower than other attributes when purchasing, which suggests that the countryof-origin effect in car purchases were underestimated by Swedish consumers. Contribution of the Thesis: This study contributes with knowledge about how country of origin affects Swedish consumers when buying a car, as well as how Swedish consumers perceive Chinese products. It also contributes with information about how Swedish consumers rank various attributes when buying a car.

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This master thesis deals with the origin of goods which is one of the key concepts in international trade. The origin of goods signifies the country where were acquired and processed. The country of origin is defined by the rules of origin and then it could be preferential or non-preferential. The first aim of this work is to explain correct proof and determination of the origin of goods, especially the emphasis is put on preferential origin of goods in the EU. The cumulation of goods is an important part of this thesis that plays the role by the producer's decision from where certain materials would be imported. The entry of the Czech Republic to the European Union stood for the acceptance of the common trade policy but also the Czech customs administration and customs policy as a whole were transformed. The final part of the work is dedicated to their competences and responsibilities.

The Master´s thesis deals with origin of goods and its importance in customs and international trade. The main objective of the thesis is to provide a complex summary of principles and rules for determination of origin of goods. A secondary objective of the thesis is to either confirm or rebut the assumption that origin frauds occur mostly in connection with non-preferential origin. The first part explains basic customs terms. The second part analyses non-preferential and preferential origin of goods. Last two parts focus on theoretical and practical aspects of origin frauds.

Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain tumor that mainly affects adults. GBM displays remarkable intra- and inter-tumoral heterogeneity and contains a subpopulation of cells named glioma stem cells that is believed to be responsible for tumor maintenance, progression and recurrence. We have established and characterized a biobank of 48 cell lines derived from GBM patients. The cells were explanted and maintained as adherent cultures in serum-free, defined neural stem cell medium. These GBM cells (GCs) displayed NSC marker expression in vitro, had orthotopic tumor initiating capability in vivo, harboured genomic alterations characteristic of GBM and represented all four TCGA molecular subtypes. Our newly established biobank is also connected with a database (www.hgcc.se) that provides all molecular and clinical data. This resource provides a valuable platform of valid in vitro and in vivo models for basic GBM research and drug discovery. By using RCAS/tv-a mouse models for glioma, we found that GBMs originating from a putative NSC origin caused more tumorigenic GCs that had higher self-renewal abilities than those originating from putative glial precursor cell origin. By transcriptome analysis a mouse cell origin (MCO) gene signature was generated to cluster human GCs and GBM tissue samples and a functional relationship between the differentiation state of the initially transformed cell and the phenotype of GCs was discovered, which provides the basis for a new predictive MCO-based patient classification. LGR5 was found to be highly expressed in the most malignant mouse GC lines of putative NSC origin and also enriched in proneural GBMs characterized by PDGFRA alterations and OLIG2 up-regulation. By overexpressing or depleting LGR5 we discovered that high LGR5 expression in proneural GC lines increased the tumorigenicity, self-renewal and invasive capacities of the cells and could potentiate WNT signalling through its ligand RSPO1. Through transcriptome analysis we identified the candidate genes CCND2, PDGFRA, OLIG2, DKK1 that were found to be regulated by LGR5. In the last study, we found that mouse OPCs could initiate both astrocytic and oligdendroglial gliomas, which indicated that oncogenic signalling is dominant to cell of origin in affecting the histology of gliomas.

BACKGROUND:Neoadjuvant chemotherapy followed by cytoreduction surgery has been used where an accurate cytologic or pathologic diagnosis is usually required before the initiation of neoadjuvant chemotherapy. However, it is difficult to make definitive diagnosis of presence of cancer cells, particularly gynecologic versus non-gynecologic origin, from those ascites specimens due to the absence of specific biomarkers of gynecologic cancers. In the present study, we evaluated if, in addition to the routine morphologic diagnosis, the biomarker PAX8 could be useful in recognition of ovarian epithelial cancer cells prior to the neoadjuvant chemotherapy.METHODS:Two hundred and two cytology specimens including 120 pretreatment ovarian cancer samples, 60 benign controls, and 22 malignant non-gynecologic cases were studied. All cytology slides were morphologically reviewed in a blinded fashion without knowing corresponding pathology diagnosis, if present. A total of 168 cytology specimens with a cell block were stained with PAX8 and Calretinin. These included patients with potential for ovarian cancer neoadjuvant chemotherapy (n=96), metastatic cancers (n=22), and benign controls (n=50).RESULTS:Among the 96 ascitic samples prior to neoadjuvant chemotherapy, 76 (79%) showing morphologic features consistent with cancers of ovarian primary were all PAX+/Calretinin-. The remaining 20 (21%) cases were positive for adenocarcinoma, but morphologically unable to be further classified. Among the 22 metastatic cancers into the pelvis, one case with PAX8+/Calretinin- represented a renal cell carcinoma and the remaining 21 PAX8-/Calretinin- metastatic cancers were either breast metastasis (n=4) and the metastasis from gastrointestinal tract (n=17). Among the 50 benign control pelvic washing cases, 5 PAX8+/Calretinin-cases represented endosalpingiosis (n=4) and endometriosis (n=1), 25 PAX8-/Calretinin+cases showed reactive mesothelial cells, and the remaining 20 specimens with PAX8-/Calretinin- phenotype typically contained inflammatory or blood cells without noticeable diagnostic epithelia.CONCLUSIONS:PAX8 identifies all Mullerian derived benign or malignant epithelia. When combining with Calretinin, PAX8 is a sensitive marker to diagnose the carcinomas of ovarian origin, which will be ideal to be used for those patients with a possible advanced ovarian cancer prior to receiving neoadjuvant chemotherapy.