The modern psychiatric crisis has become a global epidemic as the prevalence of psychiatric disorders continues to rise. These numbers have only been exacerbated by the COVID-19 pandemic, and the long-term psychological effects resulting from the social isolation and fear of the disease have yet to be seen. Those already suffering from psychiatric disorders have limited options for treatment, as current therapeutic methods for mood, anxiety, and substance use disorders demonstrate high failure rates with many individuals suffering from treatment resistance. Individuals that do respond to modern therapies typically require treatment for several weeks or months, occasionally even years, before experiencing any reductions in their symptoms. Tryptamine psychedelics have been used for millennia by indigenous cultures through highly ritualized religious ceremonies to purge individuals of disease and offer spiritual guidance, however their application within modern medicine did not begin until Albert Hofmann’s discovery of LSD in 1938. The next several decades saw an explosion in clinical studies involving tryptamine psychedelics showcasing their ability to demonstrate immediate treatment after single doses in individuals suffering from diseases such as depression and PTSD, however research and clinical practices came to a halt after the passing of the Controlled Substances Act of 1970. As renewed interest in psychedelic medicine continues to grow, this review details the therapeutic potential of tryptamine psychedelics while exploring their current status within clinical trials.

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Classic psychedelic substances, such as lysergic acid diethylamide and the active compound in magic mushrooms, psilocybin, are being studied again in a renaissance of psychedelic research. Psychedelic substances have profound effects on perception, emotion, and cognition, as well as the capacity to induce mystical-type experiences and ego-dissolution. Recent clinical studies indicate that these substances have positive effects on patient populations and healthy participants, both acutely and long-term. Neuroimaging studies show that psychedelics alter neural integration, by the disintegration of normally stable resting state networks, and increasing network connectivity between normally anticorrelated networks. This thesis will review the phenomenological characteristics of the psychedelic-induced altered state of consciousness, the therapeutic potential of the psychedelic-induced altered state of consciousness, and neuroimaging studies on the psychedelic state. Two theoretical accounts are compared on the brain basis of psychedelic-induced altered state of consciousness. From the recent research on psychedelics a novel theory of conscious states has evolved, the entropic brain theory. This theory will be compared to the integrated information theory, a well-established theory of consciousness within cognitive neuroscience.

In this paper, we explore mystical experiences and knowledge through the application of Miranda Fricker's framework of epistemic injustice. Focusing on experiences in which the usual division between Self and Other temporarily dissolves (brought about spontaneously, through contemplative or religious practice, or through the ingestion of psychedelics), we examine the knowledge gained from these experiences in its multiple forms and discuss how the mystic, when attempting to share the knowledge she has gained, may face challenges to effective testimonial exchange which constitute testimonial injustices. Similarly, due to a cultural privileging of the rational and objective, we imagine how the mystic’s interlocutor in an exchange may lack the necessary epistemic resources to understand an account of the mystic’s experience and its epistemic fruits as knowledge, thus subjecting the mystic to a hermeneutical injustice. Exploring the possibility of an anti-mystical bias, we present a new realm for the application of Miranda Fricker’s concepts.

abstract: Users of psychedelic drugs frequently report various types of healing effects after the experience has completed. How these substances actually do the healing work is still being understood. I argue that the phenomenology of the psychedelic experience is relevant to and doing at least some of the healing work. This occurs in part via the phenomenon of transformative experiences. Psychedelic experiences provide insight into first and second order desires of an individual. They alter an individual’s self-narrative and provide an ideal to aim for in addition to the motivation to achieve that ideal. Additionally, psychedelic experiences foster feelings of connection to other people and nature. This heals through altering an individual’s in-group/out-group perceptions and provide a sense of oneness which increases accurate perspective taking. The experience of ego-dissolution had under psychedelics can be compared to the ultimate transformative experience—death—which facilitates the healing process. These experiences promote social healing and serve as a reopening of previously closed possibilities due to trauma or mental illness. / Dissertation/Thesis / Masters Thesis Philosophy 2020

Several trials have reported rapid antidepressant response from the anesthetic drug ketamine although the mechanism behind this effect is not fully understood. Research has focused mainly on ketamine’s action in the brain, including its effects on chemical balance, connections between brain cells and networks, and cognition. Trials with psychedelic drugs have had similar antidepressant results as ketamine, and the quality of the subjective psychedelic experience seems to mediate antidepressant action. Ketamine causes similar alterations of consciousness, which have been viewed as side effects. This thesis examines whether ketamine works in a similar way as psychedelics, where the ketamine-induced dissociative-like experience has a relationship to antidepressant response. Leading theories of depression and ketamine’s action in the brain are presented, and eight studies examining the relationship between ketamine-induced subjective experience and antidepressant response are reviewed. Three included studies found a relationship between psychedelic- and dissociative-like symptoms and reduction in depression, while five did not. The supposed relationship between psychedelic- and dissociative-like symptoms and antidepressant action has not been adequately explored and needs further examination in clinical trials.

Backgroud: Current research suggests that psychedelics might have a significant therapeutic potential for the treatment of addictions, as well as the treatment of depression, anxiety, post-traumatic stress disorder and other mental illnesses. The current renaissance of psychedelic research, as well as changes in the approach towards these substances we see in some countries, suggest that it is only a matter of time until psychedelics are officially used as a therapeutic tool in treatment. The progressive field of addictology in the Czech Republic could be one of the pioneers of psychedelic research in the treatment of addictions. Aim: The theoretical part of this work provides insights into the current events in the field of psychedelic research in the Czech Republic and in the world. The research part maps the perspectives and attitudes of Czech experts and representatives of leading institutions (areas of addictology, research on psychedelics and mental health and state administration) on the use of psychedelics in the treatment of addictions. The aim of this work was to find out how these experts approach this issue and what possibilities and limits of implementation of research on psychedelics in the treatment of addictions they perceive. Methods: Twelve respondents took part in a qualitative...

Background: Psychedelic experience is a phenomenon that has become increasingly important in recent years. It is the subject of much research. The therapeutic potential of psychedelic substances and psychedelic experience for mental disorders, but also for addiction disorders, is interesting. This is a phenomenon that goes deep into history. Psychedelic substances were sought for altered states of consciousness during shamanic rituals. In recent history, these are substances that are often associated with the name Albert Hofmann in connection with the discovery of the effects of LSD. These are substances that are relatively safe and do not have the potential to be addictive, and are therefore of great scientific interest. Aim: The aim of this thesis is to understand the psychedelic experience and its influence on attitudes to the use of addictive substances, as well as the importance of the respondents themselves to this experience. The main goal is to describe the influence of psychedelic experience on attitudes to the use of addictive substances. How is the change taking place, whether the respondents themselves are aware of it and how they perceive it. Sample: The research group consists of 5 respondents who were selected by the method of intentional selection and the method of snowball....

This theoretical thesis is focused on mapping and comparing the leading psychological transpersonal approaches to the conception of development of consciousness of an individual. This research is exploring the theory of Ken Wilber, Michael Washburn and Stanislav Grof also paying attention to the main disagreement among them regarding the confusion of prepersonal and transpersonal spheres of consciousness. This disagreement is further elaborated in an effort to find a conclusion and to seek for an integrative theory. The theories are compared with regard to the findings about psychedelic experience. The psychedelic experience is psychologically elaborated with emphasis on the current scientific knowledge in the field and their embedding in the context of the developmental theories of consciousness taking the effort of unravelling the pre/trans fallacy and the clinical implications into account. KEYWORDS Developmental theory, consciousness, transpersonal, psychedelics, pre/trans fallacy

Recently, psychedelic science (PS) has been going through a resurge with a vast increase in publications. Psychedelic-Assisted Therapy (PAT) is demonstrating promising results across the treatment of various psychiatric disorders; however, psychedelic science remains absent from the curriculum of both medical and psychology students in Sweden. This study examined medical students' attitudes towards PS, comparing them with psychology students' attitudes, which were previously investigated. The medical students' knowledge and attitudes towards psychedelic science and its therapeutic potential were analysed using a cross-sectional survey study design. Data from psychology students were collected in the spring of 2023, while data from medical students were collected in the fall of 2023. Both datasets were based on a digital survey, Attitudes on Psychedelics Questionnaire, APQ. Multiple Mann-Whitney U tests and a chi-square test were performed across the two groups. n = 316 psychology students and n = 709 medical students answered the survey. Psychology students held more positive attitudes, rated themself as more knowledgeable and followed new findings about psychedelic science to a higher degree compared to medical students. There were no differences between the groups concerning the interests in learning about psychedelics as part of their curriculum, nor the current amount of education in PS they have received. Students who have used psychedelics themselves for recreational purposes held more positive attitudes compared to non-users. This study revealed an unmet request for education about PS from students. We argue this lack of education in PS may delay a future potential implementation of PAT in Sweden.