Environmental degradation is a burgeoning problem owing to the continual expansion of industrial production and high-levels of energy and material consumption world-wide. CP (CP) is a preventive environmental approach, aimed at increasing resource efficiency and reducing the generation of pollution and waste at source, which is being implemented globally and in South Africa. CP is not just an environmental initiative; it also supports other productivity-oriented programmes and strategies. This report deals with the development of an assessment model for CP to support the business process of a company using TM. A conceptual model for CP assessment including TM assessment of identified CP improvement options is derived. The research investigates the possibility of improving the understanding of CP by using TM frameworks. Through direct participation data was collected to compile case studies with in the South African automotive industry. Case studies identify CP focus areas and improvement techniques. Results from the CP assessments were used to forecast cost saving through the implementation of the CP techniques. The CP improvement options were assessed using three different TM methods. The main reason behind the TM assessment of CP technologies was to develop a better understating of CP from a TM perspective. Results derived from the TM assessment were used to suggest strategies to benefit managers of companies and other stake holders. The research provides a different approach towards the understanding of CP technologies and improvement options. The study attempts to link the CP process to the business process in a company using TM methods. The study contributes towards the understanding and growth of CP technologies in the South African automotive sector and states the challenges with regards to the implementation of CP in South Africa. Based on the TM assessment results, technologies strategies for CP implementation were proposed. / Dissertation (MEng (Technology Management))--University of Pretoria, 2007. / Graduate School of Technology Management (GSTM) / MEng / unrestricted

ITC/USA 2011 Conference Proceedings / The Forty-Seventh Annual International Telemetering Conference and Technical Exhibition / October 24-27, 2011 / Bally's Las Vegas, Las Vegas, Nevada / The main objectives of iNET (Integrated Network Enhanced Telemetry) are increased data rate and improved spectral efficiency [1]. In this paper we propose that transmission scheme for the physical layer is coded 16-QAM OFDM (Quadrature Amplitude Modulation-Orthogonal Frequency Division Multiplexing) which enables high data rate and spectrum efficiency. However in high mobility scenarios, where the channel is time-varying the receiver design is more challenging. Therefore in this paper pilot-assisted channel estimation is used at the receiver, with convolutional coding and error correction to enhance the performance; while the effect of inter symbol interference (ISI) is mitigated by cyclic prefix. The focus of this paper is to evaluate the performance of OFDM with 16-QAM over an aeronautical channel. The 16-QAM with OFDM enables 4 bits/symbol and provides a higher data rate than QPSK hence it is chosen in this paper. The implementation of OFDM is done using Inverse Fast Fourier Transform (IFFT) and the Fast Fourier Transform (FFT). In this paper we simulate how the performance of Coded 16-QAM OFDM is enhanced using equalization to compensate for inter symbol interference, convolutional coding is used for error correction, puncturing for improving data rate and the insertion of cyclic prefix (CP) to avoid inter carrier interference.

No description available.

LHCb is a high-precision experiment dedicated to measuring the decays of B hadrons. Particle identification at LHCb relies upon two Ring Imaging Cherenkov (RICH) detectors, and this thesis describes work carried out relating to these detectors. It includes an analysis performed to investigate ion feedback in the Hybrid Photon Detectors (HPDs) used as photosensors for the RICH system, and studies of the performance of a RICH prototype in test beam conditions. A time alignment system for the RICH detectors has been designed and implemented, and this work is presented here. Excellent particle identification performance is required for efficient reconstruction of the b → s penguin decay B0s → ØØ a channel in which visible New Physics effects are possible. An analysis of this decay has been performed, encompassing event selection at trigger and offline levels, resolution, tagging and acceptance studies, and toy monte carlo experiments on sensitivity and systematic errors in measuring the total weak phase. The results are discussed within.

The LHCb experiment (CERN) will offer a precise hadronic probe with which to study CP violation, rare decays and possible New Physics (NP) effects occurring in the b-system. Contained within the vast physics program is a dedicated and intense effort to measure the CP violating weak mixing phase, βs. This phase, observable in the neutral Bs-system, presents a sensitive indicator to NP occurring at the TeV scale. This phase appearing through the theoretically clean ¯b → ¯cc¯s quarklevel transition, can be measured precisely using Bs → J/ψφ decays. The analysis of Bs → J/ψφ decays requires using its decay angular information to separate out the CP eigenstates. The sensitivity to βs can then be extracted from the angular differential rates for this mode. This thesis presents the selection and reconstruction of this decay channel, analysis of the background specific to this channel and the method for fitting the data to extract βs. Previous studies within the collaboration have shown the βs sensitivity using a reduced angular expression for the decay rates. By studying the full angular expression, we find both a quantitative and qualitative improvement in the precision with which βs is obtained: the precision improves by approximately 20%, from ± 0.027 to ± 0.022 radians. In addition, we find it is possible to extract the b-tagging parameter from data itself, which aids to minimise the overall systematic effect. This thesis, in preparation for data taking at the LHCb, presents this expected improvement in measuring βs.

Olika typer av klorfenoler (CP) användes flitigt i impregneringsmedel under 1950–70-talen i Sverige. Det var under miljonprogrammet som CP fick sin största spridning, då en miljon hushåll skulle byggas där bland annat syllarna i husen skulle vara impregnerade med CP. På 1970-talet skedde också den så kallade Teckomatorpskandalen, där företaget BT Kemi, som tillverkade en mängd olika kemiska ämnen inklusive CP, hade grävt nercirka1000 tunnor med giftiga ämnen i marken. I samband med att skandalen uppdagades förbjöds CP år 1977-1978 i Sverige, detta innefattade även produkten KP-Cuprinol som använts som impregnering i miljonprogramhusen. Frågetecken kvarstår till hur plötsligt CP förbjöds utan att det förklarades varför. CP i trä-skyddsmedel har lett till stora inomhusproblem.

Previous work in the Rosenberg group showed that the half-sandwich complexes Ru(η5-indenyl)Cl(PR2H)(PPh3) (2i), where R = cyclohexyl (Cy), isopropyl (Pri), phenyl (Ph), para-tolyl (Tolp), react with the strong, bulky base KOBut to give highly reactive complexes Ru(η5-indenyl)(PR2)(PPh3) (6i) containing a ruthenium-phosphorus double bond, Ru=PR2. The reactions of these phosphido complexes 6i with some reagents, such as alkenes, carbon monoxide and dihydrogen, illustrate their rich and varied reactivity. To better understand the mechanisms of these reactions (whether the indenyl effect is necessary), synthesis of analogous secondary phosphine complexes containing the pentamethylcyclopentadienyl (Cp*) ligand, Ru(η5-Cp*)Cl(PPh3)(PR2H) (2) were prepared via ligand substitution at Ru(η5-Cp*)Cl(PPh3)2 (1). Cp* phosphido complexes Ru(η5-Cp*)(PR2)(PPh3) (6) were generated in situ and their reactivity was investigated to see if they behaved similarly to the indenyl complexes. Experimental evidence in this thesis suggests that variable hapticity is not necessary in our indenyl system. In addition, these experimental evidence highlights enhanced lability of ligand at the bulky Cp*Ru fragment and higher Bronsted basicity of the phosphido ligand (PR2-) in Cp* phosphido 6 relative to the indenyl analogues 6i. / Graduate / 2017-12-11 / 0488 / yangjin@uvic.ca

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

The LHCb experiment at the Large Hadron Collider (LHC) at CERN is designed to make precise measurements of processes including B and D mesons to test the Standard Model (SM) predictions for CP violation, and to search for new physics. From its inception one of the key aims of the LHCb collaboration has been to precisely measure the CP violating phase ϕs, the weak phase due to the interference between B⁰/s -B¯⁰/s mixing and decay. Having collected 3 fb-1 of data in Run 1, the combined results of LHCb measurements of ϕs from various decay modes are in agreement with SM predictions. The aim now is to improve the precision of the LHCb measurement to be sensitive to any small deviation from the SM prediction of ϕs. One strategy to achieve this, in addition to collecting more data, is to expand the number of modes used to measure ϕs to improve the sensitivity of the combination. This thesis presents the measurement of the CP violating phase ϕs in the yet unstudied B⁰/s→ ψ(2S)ϕ decay mode. In addition to providing a measurement of ϕs the study of this mode presents an opportunity to confirm the lifetime difference of the B⁰/s mass eigenstates ∆Γs, currently only measured in the B⁰/s→ Jψϕ decay mode. The results from 3 fb-1 of LHCb data are; ϕs = 0:23+0:29-0:28 ± 0:02 rad, ∆Γs = 0:066+0:041-0:044 ± 0:007 ps-1. which are in agreement with the SM and the results from the LHCb measurement from B⁰/s→ Jψϕ decays.

Cannabis (known in its common forms as Cannabis sativa or Cannabis indica) is the most widely used illicit drug in the world and has been used for thousands of years for medicinal, religious and hedonistic purposes. In the last half of the 20th century the therapeutic uses of cannabis were largely ignored as most Western governments prohibited the use of the drug. Prohibition has come about largely as a result of the view that cannabis is a dangerous drug that poses major risks to both mental and physical health. However, this view is being increasingly challenged in recent years with a major popular movement towards decriminalization of cannabis occurring in some Western countries and a resurgence of interest in the medicinal properties of cannabis. Since Mechoulam and colleagues first isolated delta 9-tetrahydrocannabinol (delta 9-THC) as the main psychoactive constituent of cannabis, considerable advances have been made in the pharmacology of cannabis and cannabis-like drugs (cannabinoids). Central and peripheral cannabinoid receptors have been isolated and two endogenous ligands have been discovered. In addition, two cannabinoid receptor antagonists have been developed. However, our knowledge of the behavioural, neural and emotional effects of cannabis and the cannabinoids has often lagged behind our understanding of basic cannabinoid pharmacology. The present thesis attempts to further the understanding of the behavioural, neural and emotional effects of cannabinoids, using laboratory rats as subjects. A synthetic analogue of delta 9-THC (CP 55,940), is used as the primary pharmacological tool. The thesis offers a broad perspective with three major areas of investigation. These are: 1) the effects of CP 55,940 on anxiety-related behaviour (Chapters 2 and 3); 2) the effects of CP 55,940 on patterns of brain activation as indicated by c-fos expression (Chapter 4) and; 3) the addictive potential of CP 55,940 and its capacity to produce sensitization to the effects of other drugs such as cocaine (Chapters 5 and 6). A recurring theme throughout the thesis is that genetic factors may partially determine the behavioural, neural and emotional response to cannabinoids. To this end, the thesis compares Lewis and Wistar trains of rat in a wide variety of assays. Previous research has isolated Lewis rats as an "addiction-prone" and a "cannabinoid-preferring" strain, as they are more sensitive to the rewarding effects of various drugs of abuse including cannabinoids. Conversely, cannabinoids appear to have aversive effects in Wistar rats. A long-standing puzzle in cannabinoid research has been the question of why rats do not self-administer cannabis or cannabinoids. One likely reason is that cannabinoids have predominately aversive effects in rats. It is proposed here that these aversive effects arise because cannabinoids are anxiogenic agents in most rat strains. However some evidence indicates that the Lewis strain of rat are the only strain to find cannabinoids rewarding. It is hypothesised that Lewis rats may be more susceptible to the rewarding effects of cannabinoids because they are less susceptible to the anxiogenic effects of these compounds. In Chapters 2 and 3 the anxiogenic effects of the synthetic cannabinoid agonist CP 55,940 were compared in Lewis and Wistar rats in several different animal models of anxiety. In Chapter 2, the predatory odour avoidance, open area avoidance and conditioned ultrasonic vocalization (USV) models were utilised. In the predatory odour avoidance model, rats were exposed to cat odour in a rectangular arena and given the opportunity to hide in a small box. Both Lewis and Wistar rats displayed high levels of hiding during odour exposure. In Wistar but not Lewis rats, 50 �g/kg of CP 55,940 (i.p.) enhanced this avoidance response. Unfortunately, Lewis rats showed exceptionally high avoidance of the cat odour making it difficult to discern the effects of CP 55,940. To avoid this problem a second experiment was conducted, where rats were tested in the same arena as in the first experiment but with no cat odour present. Again in Wistar, but not Lewis rats, 25 and 50 �g/kg of CP 55,940 (i.p.) increased the avoidance of the open space. In the third experiment, Lewis and Wistar rats were placed in a chamber in which they had previously received footshock. Wistar but not Lewis rats re-exposed under the influence of 10, 25 or 50 �g/kg CP 55,940 (i.p.) emitted significantly more USVs than vehicle-treated rats. Thus, CP 55,940 clearly increased anxiety-related behaviour in Wistar rats but not Lewis rats, supporting the notion of a genetic predisposition towards cannabinoid-induced anxiety. In Chapter 3 the generality of the findings made in Chapter 2 were tested by utilising two further animal models of anxiety, the social interaction and light-dark emergence tests. From the results of Chapter 2, it could be claimed that Lewis rats were merely subsensitive to the effects of CP 55,940. Therefore a higher dose range (0, 25, 50 and 75 �g/kg i.p.) of CP 55,940 was employed in Chapter 3. In addition, the rotarod test was used to assess whether CP 55,940 has ataxic effects at these doses. In the first experiment, two unfamiliar rats were placed in a large arena and the time the rats spent socially interacting was recorded. CP 55,940 significantly reduced the total time rats spent socially interacting in Lewis (25 and 75 �g/kg) and Wistar rats (50 and 75 �g/kg). However, CP 55,940 has a significantly greater effect in Wistar rats compared to Lewis rats. In the second experiment, rats were placed in a small box within a large open arena and the latency to emerge from this box was measured. CP 55,940 increased emergence latency (at 75 �g/kg) and mean time per entry into the box (at 25 and 75 �g/kg) in Wistar but not Lewis rats. Furthermore, CP 55,940 caused a greater decrease in time spent in the open arena (at 25 and 75 �g/kg) and frequency of emergence (at 75 �g/kg) in Wistar rats in comparison to Lewis rats. In the third experiment, CP 55,940 (at 25, 50 and 75 �g/kg) caused mild incoordination only in Lewis rats as measured by the rotarod test. This finding argues against the assertion that the CP 55,940-induced anxiety-like behaviours in Wistar rats are merely a result of motoric impairment. Furthermore, it illustrates that Lewis rats are not generally subsensitive to the effects of CP 55,940. That is, when compared to other rat strains, Lewis rats may be more or less sensitive to the effects of CP 55,940 depending on what behaviour is being assessed. From the results of Chapters 2 and 3 it can be seen that Lewis rats are less sensitive to the anxiogenic effects of CP 55,940 than Wistar rats. In Chapter 4 it was hypothesised that in Lewis rats the effects of CP 55,940 on neural substrates of reward far outweigh the effects the compound has on neural substrates mediating anxiety. To examine this issue, the effects of CP 55,940 at a moderate (50 �g/kg i.p.) and high (250 �g/kg i.p.) dose were observed on c-fos expression (a measure of neural activation) and behaviour in Lewis and Wistar rats. CP 55,940 dose-dependently inhibited locomotor activity and reduced body temperature with Lewis rats being significantly less affected than Wistar rats. The 250 �g/kg dose caused significant catalepsy in both strains with a significantly greater effect in Wistar rats. These strain differences in the effects of CP 55,940 on body temperature and motor behaviour clearly correlated with c-fos expression in various regions and subregions. In general, Lewis rats showed significantly less Fos-labeled cells in comparison to Wistar rats. These strain differences in the effects of CP 55,940 on c-fos expression appeared unique to cannabinoids, as cocaine (15 mg/kg i.p.) had equivalent effects on c-fos expression in Lewis and Wistar rats. CP 55,940 promoted c-fos expression in areas not previously assessed, such as the median preoptic nucleus (MnPO), medial preoptic nucleus (MPO), anterior hypothalamic area (AH), islands of Calleja (ICjM), periaqueductal gray (PAG) and the pedunculopontine tegmental nucleus (PPTg). The strain differences uncovered in Chapters 2 and 3 correlated well with strain differences in the effects of CP 55,940 on c-fos expression in areas implicated in cannabinoid-induced anxiety, such as the central nucleus of the amygdala, bed nucleus of the stria terminalis, paraventricular nucleus of the hypothalamus and PAG. However, the effects of CP 55,940 on c-fos expression in a neural circuit which may underlie reward, which includes the shell of the nucleus accumbens (NAS) and PPTg, were also less in Lewis rats in comparison to Wistar rats. Future investigations must address whether the reduced effects of CP 55,940 on the Lewis rat are due to pharmacokinetics or pharmacodynamics. In addition, future studies must reconcile the pattern of c-fos expression observed here with prior reports of the Lewis rat being a unique "cannabinoid-preferring" strain. In Chapter 4, CP 55,940 administration promoted c-fos expression in areas of the brain thought to play a critical role in behavioural sensitization such as the ventral tegmental area and NAS. This is interesting because it is possible that c-fos is involved in promoting neuroadaptations that underlie drug addiction. To examine this idea, Chapter 5 investigated a behavioural assay of the long-term neural adaptations that may occur with the chronic administration of cannabis, namely, behavioural sensitization. This chapter also examined an animal model of the "gateway hypothesis", that is, the hypothesis that prior exposure to cannabis increases an individuals vulnerability to using other drugs. This animal model is known as cross-sensitization. First it was shown that Lewis, but not Wistar rats, given cocaine (15 mg/kg i.p.) every second day over a two week period displayed a progressively greater locomotor response to the drug over days indicating behavioural sensitization. When CP 55,940 (0, 10, 25 or 50 �g/kg i.p.) was administered under a similar regime, no such sensitization was observed in either strain. Rather, the two highest doses of CP 55,940 (25 and 50 �g/kg) caused locomotor suppression that lasted throughout administration. When Lewis or Wistar rats pre-exposed ten times to CP 55,940 were challenged with cocaine (15 mg/kg), no exaggerated locomotor response to cocaine was evident relative to non pre-exposed rats. When these rats were subsequently re-tested with CP 55,940, it continued to produce a dose-dependent suppression of locomotor activity. Finally, when CP 55,940 (50 �g/kg) was co-administered with cocaine in Lewis rats, it significantly reduced the locomotor hyperactivity produced by the drug but did not block the development of behavioural sensitization to cocaine. These results show that CP 55,940 does not sensitize locomotor activity with repeated administration in the same way as cocaine, and that pre-exposure or concurrent exposure to CP 55,940 does not enhance sensitivity to the subsequent behavioural effects of cocaine. Therefore, unlike Chapters 2, 3 and 4 where strain differences were observed in CP 55,940?induced anxiety, hypothermia, catalepsy, c-fos expression and ataxia, there were no strain differences with respect to behavioural sensitization. Landmark studies by Gardner and colleagues showed that Lewis rats are particularly susceptible, in comparison to other rat strains, to the rewarding effects of delta 9-THC on: 1) medial forebrain bundle (MFB) self-stimulation behaviour and; 2) dopamine (DA) efflux in the NAS. However, in Chapter 4 Lewis rats were less susceptible than Wistar rats to CP 55,940-induced c-fos expression in the NAS. Further, Lewis rats showed no behavioural sensitization to the chronic administration of CP 55,940. In light of these findings, Chapter 6 assessed whether CP 55,940 does have a rewarding effect on MFB self-stimulation behaviour in Lewis rats. Lewis rats were trained to self-stimulate the MFB using a rate?frequency paradigm and then administered CP 55,940 (0, 10, 25 and 50 �g/kg i.p.). CP 55,940 had no effect on MFB self-stimulation behaviour as assessed by the M50, the stimulation frequency at which half-maximal response rates were obtained. This result calls into question previous assertions that Lewis rats are a "cannabis-preferring" strain of rat. Previous studies utilising the cannabinoid CB1 receptor antagonist, SR 141716, have shown that the endogenous cannabinoid system may have some involvement in the rewarding effects of cocaine, morphine, sucrose and alcohol. Thus, Chapter 6 also assessed the effects of SR 141716 (0, 1, 3, 10 and 20 mg/kg i.p.) on MFB stimulation in Lewis rats. The role of DA in MFB stimulation reward has already been established, so for comparison purposes the effects of the DA D1 receptor antagonist SCH 23390 (0.06 mg/kg i.p.) was also assessed. Only a very high dose of SR 141716 (20 mg/kg) caused a significant inhibition of the rewarding efficacy of the stimulation with all other doses (1, 3, and 10 mg/kg) being ineffective in modulating the rewarding impact of brain stimulation. This was seen as an increase in M50. By comparison, a relatively low dose (0.06 mg/kg) of SCH 23390 caused a large increase in M50. These results indicate a relatively modest influence of the endogenous cannabinoid system on reward-relevant neurotransmission in the self-stimulation paradigm. Chapter 7 concludes the thesis and discusses the implications of the results obtained. The main findings of the current thesis are: 1) that the suggested "addiction-prone" Lewis strain of rat is less susceptible to cannabinoid-induced anxiety in comparison to Wistar rats; 2) Lewis rats show less cannabinoid-induced c-fos expression in comparison to Wistar rats (including in brain regions implicated in cannabinoid-induced anxiety and reward); 3) cannabinoid-induced c-fos expression exists in a number of brain regions never previously assessed such as the MPO, ICjM and PPTg; 4) behavioural sensitization does not occur with the repeated administration of CP 55,940; 5) cannabinoid pre-exposure or co-administration does not increase the sensitivity of the locomotor-activating effects of cocaine; 6) the endogenous cannabinoid system, at most, only has a minor influence on the neural substrate of brain stimulation reward and; 7) that there are previously unreported strain differences in cannabinoid-induced hypothermia, catalepsy and ataxia. These results add to our understanding of the effects of the behavioural, emotional and neural effects of cannabinoids and the endogenous cannabinoid system.