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Introdução - A concentração sérica de vitamina D pode variar em indivíduos de diferentes grupos etários e de diversas regiões geográficas e pode ser influenciada pela exposição solar, estação do ano, bem como pelos valores de IMC e paratormônio (PTH). A classificação utilizada para definir concentração sérica adequada de vitamina D refere valores de 25(OH)D acima de 30 ng/mL. Porém, essa classificação pode estar inapropriada para a população brasileira, devido às particularidades climáticas e alimentares. Objetivo - Verificar as concentrações séricas médias de 25(OH)D e PTH e sua relação com IMC, exposição solar e estação do ano e identificar os valores de corte da 25(OH)D associados à elevação do paratormônio (PTH) em adultos e idosos de amostra representativa da população do município de São Paulo. Métodos - Para esta dissertação foi desenvolvido um artigo original. O artigo original descreve o estudo transversal realizado com indivíduos do estudo ISA-Capital, estudo multicêntrico e de base populacional, onde foram investigados 589 indivíduos, de ambos os sexos, dos grupos etários: 20 a 59 (adultos) e 60 e mais (idosos). Foram coletadas amostras de sangue, para dosagens de 25(OH)D e PTH. Os indivíduos que aceitaram participar da coleta de sangue, também responderam um questionário sobre exposição solar. A análise estatística incluiu a curva ROC, testes t de Student, correlação e ANOVA. Os cálculos foram realizados pelo software SPSS versão 17.0. e p 0,05 foi considerado significante. Resultados - No artigo original observou-se idade média de 54,83 (19,21) anos, sendo 61,3 por cento do sexo feminino e 38,7 por cento do sexo masculino. A concentração sérica média de 25(OH)D foi 50,02 (22,69) ng/mL, já entre os grupos foi de 47,48 (23,03) (adultos) e 52,68 (22,06) ng/mL (idosos) havendo diferença significativa entre eles (p=0,005). Observou-se variação sazonal da concentração sérica de 25(OH)D e correlação positiva entre 25(OH)D e IMC (r = 0,114, p = 0,006). O novo valor de corte 55.8 ng/mL, determinado pela análise da curva ROC, encontrou 67,6 por cento dos indivíduos insuficientes de 25(OH)D e entre os grupos 72,1 por cento (adultos) e 62,8 por cento (idosos). Conclusão - Os resultados demonstram a presença de variação sazonal nas concentrações séricas de 25(OH)D no municipio de São Paulo. O ponto de corte proposto para nossa população indicou elevada prevalência de insuficiência de vitamina D. Portanto, se faz necessário políticas públicas de prevenção de insuficiência de vitamina D visando os efeitos benéficos na saúde e qualidade de vida desta população. / Introduction - The serum concentration of vitamin D may vary in individuals of different age groups and geographic regions and may be influenced by sun exposure, season and by BMI and parathyroid hormone (PTH). The classification widely used as a cut-off for appropriate vitamin D status refers serum 25 (OH) D above 30 ng/mL. However, this classification may be inappropriate for the Brazilian population, due to the particular food and the climate of our population. Objective - To determine the mean serum concentrations of 25(OH)D and PTH and correlate them with BMI, sunlight exposure and season and to identify the cutoff values of 25 (OH) D associated with elevation in PTH. Methods For this dissertation, one original article were developed. Original article describe cross-sectional study performed with subjects from the ISA Capital, multicenter population-based. We investigated 589 individuals were of both sexes, age groups: 20-59 (adults) and 60 (elderly). Blood samples for laboratory measurements of 25(OH)D and PTH were collected. Individuals, who agreed to participate in blood collection, also answered a questionnaire on sunlight exposure. Statistical analysis included ROC curve, Student t test, correlation tests, ANOVA. The calculations were performed by the software SPSS version 17.0. and p 0.05 was considered significant. Results - In the original article, the mean age of participants was 54.83 (19.21) years, 61.3 per cent female and 38.7 per cent were male. The mean serum 25 (OH) D was 50.02 (22.69) ng/mL, between the groups was 47.48 (23.03) (adults) and 52.68 (22.06) ng/ mL (elderly) and significant difference between them (p = 0.005). A seasonal variation in serum 25 (OH) D was observed and positive correlation between 25(OH)D and BMI (r = 0.114, p = 0.006). The new cutoff value 55.8 ng / mL, determined by ROC curve analysis found 67.6 per cent of subjects insufficient 25 (OH) D and between groups 72.1 per cent (adults) and 62.8 per cent (elderly). Conclusion - The results demonstrate the presence of seasonal variation in serum 25 (OH) D in the municipality of Sao Paulo. The cutoff point proposed for our population showed a high prevalence of insufficient vitamin D. Therefore, public policy is needed to prevent vitamin D insufficiency in order to beneficial effects on health and quality of life in this population.

Developing from the recent surge of interest in the Royalist cause during the Civil Wars, this thesis explores the question of how Royalists were portrayed in the press between 1637 and 1646. It addresses the question through textual analysis and specifically examines printed material in an effort to investigate the construction of Royalist identity as well as the peculiarities of Royalist discourse. At its most fundamental level, this thesis seeks to address the issue of Royalist identity, and in doing so suggests that it was predicated on an inconsistent and problematic form of English patriotism. According to the argument presented here, Charles I led a cause that was supposed to protect and champion the core institutions and cultural norms upon which the very nature of Englishness rested. Royalism existed to preserve England from what were perceived as the foreign and anti-English agendas of Parliament. An underlying argument in this thesis is that Royalist print aspired to define and anchor language, with the implication that textual meaning was solidly formed and unquestionable. Royalist text, unlike that of Parliament, was supposed to represent truth, effectively rendering Royalist print a force for stability in an increasingly chaotic world. Alongside its focus on the ways in which the Royalist press tried to fashion an English identity for the King’s supporters, this thesis also explores the image of the cavalier stereotype. It aims not to debunk such a stereotype, but to explore the implications behind it and show how they challenged and undermined the Royalists’ Englishness.

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Puritans entered a novel position of power in the early 1640s. Their attempts to ‘combat’ heretics and further reform in the 1640s/50s were impeded by the dismantling of legal and ecclesiastical apparatus previously employed against them. Influential Presbyterians and Independents in Parliament, the Westminster Assembly, and the New Model Army, were also divided over defining orthodoxy, enforced conformity to a national Church and liberty of conscience. Chapter one addresses crucial developments in defining and punishing heresy, in the Early Church, and in England, from the first noted burning of a heretic under Henry IV up until the outbreak of Civil War. Existing fractures within Puritanism intensified as lapsed censorship produced an explosion of new or public heterodox ideas. Chapter two explores disagreements over legitimate means of reform and establishing ‘truth’, by examining the case of anti-Trinitarian Paul Best which initiated a Parliamentary Ordinance to enable execution of obstinate heretics. This legislation generated public controversy, especially in print. Chapter three addresses the significance of preaching, fasting and prayer as spiritual means to oppose heresy, and emphasis on collective national responsibility and repentance. Particular attention is paid to the Humiliation for heresy on 10 March 1647. Chapter four compares the differing political and ecclesiological contexts which produced the Heresy Ordinance and the 1650 Blasphemy Act, especially a shift from Presbyterian to Independent dominance in positions of government. The Rump settlement was predominantly shaped by a magisterial Independent vision of reform. Chapter five addresses Interregnum problems with enforcing the Blasphemy Act and upholding liberty offered in the Instrument of Government. The cases of Socinian John Biddle and Quaker James Nayler reveal fears of unrestricted definitions of heresy, and rigidly defined orthodoxy. Overall across these decades, concerns to avoid establishing precedents which could endanger the godly prevented systematic suppression of heresy and blasphemy.

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Though the debate surrounding the extent to which pessimism dominated in the late nine-teenth century asylum is extensive, the same debate in the twentieth century remains un-der-explored. Relatively few academics have offered a cross-century analysis that goes beyond the beginning of the First World War to analyse the twentieth century and none of these studies have explored how changes were implemented in the institutions in the West Riding of Yorkshire. This thesis attempts to redress this imbalance by offering an original analysis of a selection of developments and innovations that were carried out in the West Riding of Yorkshire between the years 1888-1938. Consideration is given to four specific innovations and an analysis is made of how successful these new develop-ments were with relation to the eradication of the stigmas of pauperism and certification. Innovations relating to how to segregate mentally deficient children and adults and ser-vice patients will be assessed, along with the establishment of outpatient departments and the local implementation of the 1930 Mental Treatment Act. By offering an analysis of these developments this thesis contributes to our understanding of how successful these social and legal changes were in the administration of mental health care throughout these years. Primarily this thesis is concerned with an analysis of these different innovations and an observation of the impact that these attempts at change had on the patients. Wherever possible close attention is given to the voices of the patients and their families in order to assess their roles in accessing the services provided. This thesis argues that these innova-tions represent significant legal and social changes in the administration and admission of the mentally ill over the years covered. Despite this however, this thesis identifies that these changes were all beset with many inherent problems, usually linked to a lack of fi-nance and overcrowded institutions, which meant that they were all significantly limited in their capacity to change the system for all but a small minority of sufferers of mental illness and learning disability.

The focus of this thesis is an investigation of secondary school history in post-genocide Rwanda. The thesis addresses a knowledge gap by examining the 2008 O-level Rwandan history curriculum as a case of a post-genocide secondary school history curriculum. The issues surrounding the construction of the 2008 O-level history curriculum and the wider opportunities and challenges of teaching and learning history in Rwandan schools are addressed. The research is located in the field of literature that investigates school history in different post-genocide and post-conflict countries and the connections between history education, conflict, peace and reconciliation. Research involved two periods of fieldwork in Rwanda of 11 weeks and 16 weeks respectively. During this time curriculum documents were collected and field-notes taken. Also, interviews were conducted with Rwandan policy-makers (3), secondary history teacher-educators (5) and secondary history student-teachers (10). Informal discussions were held with four additional policy-makers. The empirical research was related to the research question: What opportunities and challenges does teaching history face in post-genocide Rwanda - perceptions of what, why and how history is taught to secondary school pupils? A thematic analysis of the data resulted in three key inter-related findings. Firstly, there are competing policy visions and curriculum processes at the heart of the 2008 O-level secondary school history curriculum. Secondly, the memory of the 1994 genocide is central to the 2008 O-level history curriculum construction (policy), mediation (teacher-educators) and implementation (student-teachers). Finally, and related to finding two above, limited learner-centeredness in student-teachers’ classroom practice demonstrates how the legacy of the Rwandan 1994 genocide impacts on the delivery of the 2008 O-level history curriculum. Based on these findings the thesis makes three original contributions to knowledge. The legacy of the genocide in terms of post-genocide fears of future violence and aspirations for unity and reconciliation needs to be at the centre of our understanding of school history curriculum reform in post-genocide Rwanda. Also, over 20 years after the 1994 genocide the on-going emotional legacy of the genocide in the classroom shapes the classroom practice of a new and university trained generation of history teachers. Yet, student-teacher classroom practice also challenges the uniform depiction of teacher-led history teaching by writers, suggesting a more complex history classroom reality. Finally, this is the first empirical study to use the theoretical framework of ‘unity in homogeneity’, ‘unity in diversity’ and ‘diversity’ approaches to frame and investigate the opportunities and challenges the teaching of history faces in post-genocide Rwanda.

Triacetyl-D-glucal, an unsaturated sugar has been prepared and submitted to the hydroformylation reaction, which is the addition of carbon monoxide and hydrogen to an unsaturated compound at high pressure and temperature. A cobalt catalyst is generally used, in this case, cobalt acetate tetrahydrate. The mixture of products obtained was separated by column chromatography and distillation. The main products are probably triacetyl-D-deoxyglucose obtained by the addition of water to the starting material, 1,2-hydroglucal obtained by hydrogenation of the starting material, a small amount of the theoretical hydroformylation compound and varying amounts of the starting material. / Science, Faculty of / Chemistry, Department of / Graduate