Ο σκοπός της παρούσης εργασίας είναι να εξετάσουμε την κινητική απελευθέρωσης υδρόφιλων και λιπόφιλων μορίων που εγκλωβίζονται σε λιποσώματα, όταν τα λιποσώματα διασπείρονται σε συστήματα φορέων- υδρογελών. Στην παρούσα εργασία μελετάται η απελευθέρωση της υδατοδιαλυτής ουσίας καλσεΐνης και της λιποδιαλυτής γκριζεοφλουβίνη τόσο από σταθερά λιποσώματα (DSPC:Chol) όσο και από ασταθή (PC) διεσπαρμένα σε φορείς υδρογελών. / Release of calcein and griseofulvin (GRF) from control (gels in which solutes are dissolved in) and liposomal gels was studied using agarose-assisted immobilization as a technique to separate gels from drug-receptor compartments.Results show that calcein release from liposomal gels is slower compared to control gels, and can be further retarded by using rigid-membrane liposomes (faster release from PC-liposome compared to DSPC/Chol-liposome gels).Additionally, calcein release is not affected by the lipid amount loaded (in the range from 2 to 8 mg/ml), therefore solute loading can be controlled according to needs. Oppositely, GRF release from liposomal gels is determined by drug loading. At high drug loading levels (compared to GRF aqueous solubility), GRF is released with constant rate from liposomal gels irrespective of liposome type (PC or DSPC/Chol). Thereby, for amphiphilic/lipophilic drugs, drug properties (solubility, log P) determine the system behavior. Calcein and GRF release from control carbopol gels is faster compared to HEC and mixture gels. The same is true for calcein in liposomal gels. Carbopol gel rheological properties were found to be significantly different (compared to the other gels), implying that these characteristics are important for drug diffusion from gels.