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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 201 to 210 of 694 (0.022 seconds)Spelling suggestions: "subject:"“neoplasms”"" "subject:"“neoplasia”""
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Exploring the many facets of cell deathMénard, Isabelle. January 2007 (has links)
This thesis summarises research performed with the intent of exploring the many facets of cell death. In the first part of the thesis, the fate of the formin-homology domain containing protein FHOD1 during apoptosis is examined (research performed in the laboratory of Dr. Sophie Roy) and evidence for the cleavage of FHOD1 by caspase-3 at the SVPD616 site is demonstrated. Moreover, the C-terminal FHOD1 cleavage product is shown to translocate to the nucleolus where it inactivates RNA polymerase I transcription. / In the second part of the thesis, the role of the RNA-binding protein HuR in cancer cell migration and invasion, as well as in multidrug resistance is determined using RNA interference to knockdown the expression of HuR in HeLa and KB-V1 cells respectively (research performed in the laboratory of Dr. Imed Gallouzi). In this part of the thesis, HuR is shown to promote cancer cell migration and invasion by stabilizing the beta-actin mRNA in a U-rich-dependent manner. Moreover, evidence is shown for the potential involvement of HuR in the phenomenon of multidrug resistance possibly through the post-transcriptional regulation of the multidrug resistance 1 gene.
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| 202 |
On the mechanisms and consequences of cell to cell DNA transfer /Ehnfors, Jacob, January 2007 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.
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| 203 |
Colon cancer : management and outcome in a Swedish populaiton /Sjövall, Annika, January 2007 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.
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| 204 |
Immunological studies in malignant melanoma : importance of TNF and the thioredoxin system /Barral, Ana María, January 2001 (has links)
Diss. (sammanfattning) Linköping : Univ., 2001. / Härtill 5 uppsatser.
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| 205 |
Novel genes in gonadal development /Töhönen, Virpi, January 2002 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2002. / Härtill 5 uppsatser.
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| 206 |
Prognostic factors in early stages (FIGO I-II) of epithelial ovarian carcinoma /Ingiríður Skírnisdóttir. January 2002 (has links)
Diss. (sammanfattning) Uppsala : Univ., 2002. / Härtill 5 uppsatser.
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| 207 |
Molecular genetic markers of prostate cancer development /Valdman, Alexander, January 2003 (has links)
Licentiatavhandling (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 3 uppsatser.
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| 208 |
Molecular markers and new techniques in the evaluation of colorectal cancer /Lenander, Claes, January 2002 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2002. / Härtill 5 uppsatser.
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| 209 |
Multiparameter flow cytometry and minimal residual disease in patients with acute leukemia /Björklund, Elisabet, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 6 uppsatser.
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| 210 |
Resistance mechanisms for nucleoside analogues - with focus on metabolism and apoptosis /Månsson, Emma, January 2002 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2002. / Härtill 6 uppsatser.
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