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Photodynamic therapy (PDT) currently utilizes drug and light doses which are primarily based on clinical experience. This can lead to a dose which is not sufficient to destroy the entire tumor, or alternatively, it can lead to the undesirable destruction of healthy tissue around the treatment area. PDT of topically applied photosensitizers is one focus of this research. This concerns the diffusion of an externally applied drug into the tissue, as well as its subsequent destruction during the irradiation procedure. This work involves the non-invasive measurement of the inherent fluorescence of the photosensitizer, allowing the determination of the concentration and distribution of drug within the tissue, and thus optimizing this treatment. To do this, one must be able to describe the propagation of light within the tissue. Consequently, a photon diffusion model has been developed to calculate the steady-state spatially resolved fluorescence from a pencil beam excitation in a depth dependent medium. The validity of this model was then verified by comparison with Monte Carlo simulations and measurements made on phantoms with optical properties similar to those of human tissue. Theoretical conditions were then explored, and potential uses of the model were demonstrated. / Thesis / Master of Science (MS)

Yes / Local scour around submarine pipelines can affect the stability of the pipeline. The accurate estimation of the scour around submarine pipelines has been a hot topic of research among marine engineers. This paper presents results from a numerical study of clear-water scour depth below a submarine pipeline for a range of the steady flow conditions. The flow field around the pipeline under scour equilibrium condition is numerically simulated by solving the Reynolds-Averaged Navier-Stokes (RANS) equations with the standard k-ε turbulence closure. The flow discharge through the scour hole for various flow conditions is investigated. The results are used to establish the relationship between the flow discharge and the maximum scour depth. Incorporated with the Colebrook-White equation, the bed shear stress is obtained and an iterative method is proposed to predict the scour depth around the submarine pipeline. The calculated scour depths using the present method agree well with the laboratory measurements, with the average absolute relative error being smaller than that using previous methods, indicating that the proposed method can be used to predict the clear-water scour around the submarine pipeline with satisfactory accuracy. / National Nature Science Fund of China (Grant No.50879084, 51279189), the Open Fund from the State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University (SKHL1302),China Scholarship Council, Public Projects of Zhejiang Province (2016C33095) and the Natural Science Fund of Zhejiang Province (LQ16E090004).

As the world moves towards more green technology and energy-resources, the need for rare earth elements (REE) has increased rapidly. A potential secondary resource for REE’s are mine tailings, and a technique to estimate the thickness of a tailing is the horizontal-to-vertical spectral ratio (HVSR) method. In this project, the depth of a mine-tailing along a profile in Blötberget was estimated using this method. The HVSR method is a non-invasive environmentally friendly seismic method which utilizes ambient noise of the Earth. The method uses seismic sensors consisting of 3 components, which measures ground motion in three directions. The acquired data was processed in the Geopsy software, where certain parameters, such as filtering and window selection, are set to make the most satisfactory results. The Geopsy software provides the user HVSRs for the selected windows. This ratio makes up a curve in the frequency domain, where a fundamental resonant frequency can be derived. The fundamental frequency is determined as the sharp, lowest-frequency peak in the data in case of a strong velocity contrast. This fundamental frequency must fulfil certain criteria to be considered reliable. When the fundamental resonant frequencies could be determined reliable, they were mathematically calculated into the thickness of the tailing by a simple mathematical formula in Excel, using the shear-wave velocity of the overlying layer and the fundamental frequency. The elevation at the location of each sensor and the thickness of the contrasting interface is used to provide a 2-D depth of the mine-tailing. This profile was compared to radiomagnetotelluric measurements. Although the measurement locations were not coinciding reasonable results were obtained.

In recent years, the placement of phasor measurement units (PMUs) in electric transmission systems has gained much attention. Engineers and mathematicians have developed a variety of algorithms to determine the best locations for PMU installation. But often these placement algorithms are not practical for real systems and do not cover the whole process. This thesis presents a strategy that is practical and addresses three important topics: system preparation, placement algorithm, and installation scheduling. To be practical, a PMU strategy should strive for full observability, work well within the heterogeneous nature of power system topology, and enable system planners to adapt the strategy to meet their unique needs and system configuration. Practical considerations for the three placement topics are discussed, and a specific strategy based on these considerations is developed and demonstrated on real transmission system models. / Master of Science

Feeding selectivity by the rainbow mussel (Villosa iris) was examined for three age groups; 2-3 days old, 50-53 days old, and 3-6 years old. The mussels were fed an algal diet consisting of Scenedesmus quadricauda (22.3 - 44.5 μm), Nannochloropsis oculata (2.8 – 8.1 μm), and Selenastrum capricornutum (3.6 – 8.5 μm) in equal cell densities. The change in relative abundance of each algal species within feeding chambers over a 5 hr feeding trial was used to discern selectivity. At the conclusion of the feeding trials, the gut contents of mussels were analyzed for preferential ingestion. The mussels selected for N. oculata and S. capricornutum over S. quadricauda (p < 0.05). This may be an indication of particle size-dependent selection. Feeding trials also suggest that selectivity by the rainbow mussel does not change with age. Gut content analyses showed a preferential ingestion of algae, in the sequence N. oculata, S. capricornutum, then S. quadricauda. The suitability of two algal diets, S. quadricauda and N. oculata, for rearing captive juveniles of V. iris in 145-L recirculating culture systems was compared. Juveniles were fed their assigned diet at a density rate of approximately 30,000 cells/ml for 42 days, and sampled weekly for percent survival and shell length. Regardless of diet, juvenile survival decreased rapidly after 21 days, and growth did not exceed approximately 450 μm. High mortality rates and slow growth of juveniles was likely due to inadequate diets. Juveniles that were fed S. quadricauda lacked chlorophyll coloration in their guts, indicating that the juveniles did not ingest this species of algae. Colonies of S. quadricauda were likely too large for the juveniles to ingest. The gut content of juveniles fed N. oculata showed chlorophyll coloration, indicating that the juveniles ingested this species, but N. oculata may have been difficult for the juveniles to assimilate. Under the culture conditions provided, survival and growth did not compare favorably to those of other studies with V. iris. Newly metamorphosed juveniles of V. iris were reared in 145-L recirculating culture systems containing sediment (< 600 μm) of two depths, 5 mm and 15 mm. Mussels were fed a bi-algal diet of Nannochloropsis oculata and Neochloris oleoabundans. Survival differed significantly between treatments (p=0.04), and was higher for juveniles reared in 5 mm of sediment over a 40-day period. Growth was not significantly different between treatments. After 40 days, juveniles achieved a mean length of approximately 578 μm in both treatments. Survival and growth of juveniles compared favorably to those of other culture studies using juveniles of V. iris. A shallow layer of sediment is recommended for the culture of juvenile mussels. / Master of Science

Traditional laser scanning systems, such as those used for microscopy, typically image objects of finite thickness. If the depth-of-focus of such systems is low, as is the case when a simple clear pupil is used, the object must be very thin or the image will be distorted. Several methods have been developed to deal with this problem. A microscope with a thin annular pupil has a very high depth-of-focus and can image the entire thickness of a sample, but most of the laser light is blocked, and the image shows poor contrast and high noise. In confocal laser microscopy, the depth-of-focus problem is eliminated by using a small aperture to discard information from all but one thin plane of the sample. However, such a system requires scanning passes at many different depths to yield an image of the entire thickness of the sample, which is a time-consuming process and is highly sensitive to registration errors. In this thesis, a novel type of scanning system is considered. The sample is simultaneously scanned with a combination of two Gaussian laser beams of different widths and slightly different temporal frequencies. Information from scanning with the two beams is recorded with a photodetector, separated electronically, and processed to form an image. This image is similar to one formed by a system using a difference-of-Gaussians pupil, except no light has been blocked or wasted. Also, the entire sample can be scanned in one pass. The depth-of-focus characteristics of this synthesized difference-of-Gaussians pupil are examined and compared with those of well-known / Master of Science