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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 961 to 970 of 1467 (0.039 seconds)| 961 |
The Role of the Prefrontal Cortex and Stress in Huntington Disease-Mediated AggressionVyas, Kadambari 01 January 2022 (has links)
Huntington Disease (HD) is a fatal neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric symptoms. Although HD onset is determined by motor symptoms, psychiatric symptoms, like depression and aggression, can develop earlier, have a larger impact on quality of life, and are understudied due to stigma. Our lab has observed hyper aggression in our humanized HD mouse model (Hu97/18) compared to our knock-in HD mouse model (Q175FDN). We characterized these differences and found that the Hu97/18 mice overreact in neutral situations, behaving as if they are in threatening situations. We are now using this novel model of HD-related aggression to study its neurological basis. Increased reactive aggression has been linked to stress levels and the prefrontal cortex (PFC) due to its role in emotional regulation. This study seeks to determine if HD-related aggression is associated with increased stress levels and changes in the PFC. Our cortisol study shows that the Hu97/18 mice display significantly higher cortisol levels than baseline, suggesting a link between systemic stress and heightened aggression. Additionally, quantified PFC volumes show a moderate relationship between PFC volume and aggression in wild-type (WT) mice that is lost in the Hu97/18 mice. This data will help elucidate factors that modulate aggression in HD and may identify therapies with high potential to alleviate this devastating symptom in patients.
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| 962 |
IN VIVO ACTIVATION OF CHANNELRHODOPSIN-2 USED TO DETERMINE THE ROLE OF SPONTANEOUS NEURAL ACTIVITY IN AXONAL GUIDANCEKastanenka, Ksenia V. January 2011 (has links)
No description available.
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| 963 |
DORSAL HIPPOCAMPUS INFUSIONS OF CNQX INTO THE DENTATE GYRUS DISRUPT EXPRESSION OF TRACE FEAR CONDITIONINGPierson, Jamie L. 12 December 2012 (has links)
No description available.
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| 964 |
Dynamical Architectures for Controlling Feeding in <i>Aplysia californica</i>Shaw, Kendrick Matthew 21 February 2014 (has links)
No description available.
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| 965 |
Role of the Reticulospinal and Corticoreticular Systems for the Control of Reaching in Non Human Primates.Montgomery, Lynnette Ruth January 2013 (has links)
No description available.
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| 966 |
Neuroprotection of Dopaminergic Neurons and their Subcellular Structures from Parkinson's Disease-like TreatmentWiemerslage, Lyle N. 12 June 2014 (has links)
No description available.
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| 967 |
Multifunctionality of the I3 Muscle of Aplysia via Regional Activation by Identified NeuronsMcManus, Jeffrey M. 11 June 2014 (has links)
No description available.
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| 968 |
Interactions between hippocampal and cerebellar theta oscillations during cerebellar theta-contingent trace eyeblink conditioning acquisition and extinction in the rabbit.Hoffmann, Loren C. 21 April 2014 (has links)
No description available.
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| 969 |
Role of RACK1 in axonal outgrowth of developing neuronsSerre, Joel M. 16 May 2014 (has links)
No description available.
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| 970 |
Parsing Variability: Variability in Aplysia Feeding Motor Programs and Behavior Performance due to Behavioral Differences, Individuality, and Sensory FeedbackCullins, Miranda J. 02 September 2014 (has links)
No description available.
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