The present kinetic study of the permeability of rabbit erythrocytes has established that carrier systems are involved in the penetration of certain non-electrolytes. Saturation, competitive inhibition, and butanol inhibition kinetics were used to demonstrate the presence of carrier systems and the values of half-saturation constants (ø) were determined for the following water soluble non-electrolytes: glycerol, ethylene glycol, urea, and thiourea. These non-electrolytes are commonly used in permeability studies because they are relatively non-toxic and their small sizes allow penetration of the erythrocyte membrane within a reasonable length of time.

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No description available.

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<p> Carrageenan, a mixture of sulphated galactans extractable by hot water from certain marine algae, has been known for its activity in a reversible stimulation of connective tissue growth. One subcutaneous injection of this polysaccharide elicits a granuloma formation which regresses after a few weeks. A single injection after regression results in heightened response; this suggested an immunological reaction. Serial injections of either lambda or kappa carrageenan into rabbits resulted in the formation of precipitins. The present study gives both qualitative and quantitative studies of the reaction involved. Fractions of carrageenans from different species of marine algae were tested for their ability to precipitate either anti-lambda carrageenan antiserum or anti-kappa carrageenan antiserum. Deductions were made from the data as to the structure of the polysaccharides.</p> / Thesis / Master of Science (MSc)

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

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This study, conducted at Camp Pickett, Virginia, attempted to evaluate several rabbit management practices currently in use on this deactivated military reservation. The methods being applied by the Virginia Come mission of Game and Inland Fisheries consist of establishment of wildlife food plots, the seeding of fire lanes and mowing and burning as a means of retarding ecological succession. Results of these evaluations indicated that the annual mixture plot is the type most heavily utilized by rabbits during the fall. Next in importance was the clover-winter grain combination planting. These conclusions were determined by means of live trapping and these trapping data were substantiated by pellet counts. A total of 211 rabbits were handled in this phase of the study; 135 were marked and 76 were recaptured. Of the 135 animals marked, 40.8 per cent were marked in the annual mix plots. This trapping demonstrated a sex ratio of 130 males to 100 females and an immature to adult female ratio of 2.3:1. A relationship between trapping success and temperature seemed to exist; a coefficient of correlation of -0.273 was calculated. A vegetative inventory inferred that both mowing and burning may be desirable rabbit management practices. An attempt was made to test three population estimation formulae on a known, enclosed rabbit population. Results of trapping within the five acre enclosure gave a comparable population estimate fer the Lincoln index, the Krumholz formula and the Schumacher-Eschmeyer formula. This experiment was not carried to the refined point of supplying definite conclusions; further investigation is necessary before concrete recommendations may be made. Records of the hunting season harvest were maintained. When these kill figures were combined with a rough estimate of the rabbit population on Camp Pickett, it was indicated that approximately 26 per cent of the cottontails were harvested. Hunting kill records maintained by the Game Commission over the past three years show a marked increase in hunter success, probably due te the effects of management. All bot fly parasitism cases were noted; 155 infestations were observed among the 325 rabbits handled. The larvae demonstrated no preference as to sex of the host but immature cottontails were more heavily parasitized than were adults, Records of tularemia incidence throughout Virginia have been maintained. Two areas of greater incidence occur; however, the Camp Pickett area appears to be average for the state. Cost comparisons were made between annual mix plots and clover-winter grain plots. The annual mix type of food plot cost an estimated $7.30 per half acre te install; the clover plot cost $18.09 per half acre. Which type plot, annual or perennial, is used depends upon the budget and Labor available. The writer favors use of the clover plots for rabbits both from the economical and biological points of view. / Master of Science

Master of Science