Thesis (M.S.)--Mississippi State University. Department of Agricultural and Biological Engineering. / Title from title screen. Includes bibliographical references.

Thesis (Ph. D.)--University of Michigan, 1930. / Caption title: Comparative studies of the metabolism of the amino acids. V. The oxidation of phenylalanine and phenylpyruvic acid in the organism of the rabbit, by Joseph P. Chandler and Howard B. Lewis. "Reprinted from the journal of biological chemistry, vol. XCVI, no. 3 ... June, 1932." Bibliography: p. 635-636.

Thesis (Ph. D.)--University of Michigan, 1930. / Caption title: Comparative studies of the metabolism of the amino acids. V. The oxidation of phenylalanine and phenylpyruvic acid in the organism of the rabbit, by Joseph P. Chandler and Howard B. Lewis. "Reprinted from the journal of biological chemistry, vol. XCVI, no. 3 ... June, 1932." Bibliography: p. 635-636.

Thesis (M.S.)--University of Alabama at Birmingham, 2007. / Title from PDF of title page (viewed October 13, 2009). Additional advisors: Brigitta C. Brott, Jack E. Lemons, Steven G. Lloyd. Includes bibliographical references (p. 28-31).

Thesis (M. Med. Sc.)--University of Hong Kong, 2003. / Includes bibliographical references (leaves 81-94). Also available in print.

Thesis (doctoral)--Københavns Universitet. / Summary in Danish.

Thesis (Ph. D.)--University of Wisconsin, 1947. / Typescript (carbon copy). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 127-145).

Thesis (Ph. D.)--University of Alabama at Birmingham, 2006. / Description based on information viewed Oct. 3, 2006; title from title screen. Includes bibliographical references (p. 87-90).

Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 192-211).

O papel dos nucleotídeos da adenina na função vascular e plaquetária já está bem estabelecido. Apirase (CD39) faz parte de uma família de ecto-enzimas capazes de hidrolisar nucleosídeos di- e trifosfatados da adenosina e sua participação no sistema tromborregulador tem sido estudada. Nós utilizamos um modelo experimental in vivo de trombose arterial aguda para testar a hipótese de que a administração de apirase solúvel pode prevenir a formação de trombos. Vinte e cinco coelhos brancos Nova Zelândia foram submetidos à lesão arterial com cateter balão e, após 15 dias, a um protocolo indutor de trombose. Treze animais receberam duas administrações intravenosas de apirase solúvel (com 90 minutos de intervalo) e 12 animais foram utilizados como controle. Após 3 horas do protocolo indutor de trombose, os animais foram mortos e a taxa e área de trombose foram avaliadas. A taxa de trombose no grupo apirase foi significativamente menor que no grupo controle (69% vs. 16,7%, respectivamente, P=0,015) assim como a área de trombose (1,7 mm2 ± 4,3 vs. 21,7 mm2 ± 37,4, respectivamente, P=0,008). Nossos resultados confirmam a participação da apirase na homeostasia através de um potente efeito antitrombótico. / The role of adenine nucleotides on vascular and platelet functions has long been established. Apyrase (CD39) takes part of a family of ecto-enzymes that hydrolyze adenosine di and triphosphate and its participation on thromboregulatory system is under study. We used an in vivo experimental model of acute arterial thrombosis to test the hypothesis that administering soluble form of potato apyrase could prevent thrombus formation. Twenty five white New Zealand male rabbits suffer balloon aortic endothelium denudation and fifteen days after were submitted to a thrombosis triggering protocol with a procoagulant (Russel’s viper venom) and epinephrine. After the thrombosis triggering protocol 13 animals received two soluble apyrase administration (with 90 minutes interval) and 12 animals that received no treatment were used as controls. Three hours after the triggering protocol, the animals were killed and the rate and area of arterial thrombosis were analyzed. The rate of thrombosis in the apyrase group was significantly lower than the control group (69% vs. 16,7%, respectively, P= 0,015) as well as the area of thrombosis (1,7 mm2 ± 4,3 vs. 21,7 mm2 ± 37,4, respectively, P=0,008). Our results confirm that apyrase do participate in homeostasis through a potent antithrombotic effect.