Thousands of animal experiments have demonstrated that androgenic hormones, such as testosterone, during the prenatal and early postnatal periods, masculinise and defeminise various neural and behavioural characteristics that differ by sex. Can these findings from animal experiments be generalised to human behaviour? Can early androgen exposure shape subsequent gender-related disorders in humans? Chapter 1 (Introduction) provides an overview of the literature. Chapter 2 (Kung et al., 2016a) is the first study to demonstrate that testosterone concentrations in saliva samples collected during the early postnatal testosterone surge at 1 to 3 months of age can negatively predict subsequent expressive vocabulary size (how many words a child can say) during toddlerhood. Notably, males typically have a smaller expressive vocabulary than do females during toddlerhood and a small expressive vocabulary is predictive of subsequent language difficulties, such as dyslexia and stuttering, which are more common in boys. Chapters 3 (Kung et al., 2016b) and 4 (Kung et al., 2016c) evaluate a popular theory of autism, the extreme male brain theory, which argues that heighted androgen exposure during early development causes the male preponderance in autism. To test the hypothesised relationship, Chapters 3 and 4 use different measures and study populations, including testosterone concentrations in amniotic fluid samples obtained prenatally and saliva samples obtained during the early postnatal testosterone surge in typically developing children, as well as examining the adjustment in children exposed to unusually high levels of androgens prenatally due to congenital adrenal hyperplasia (CAH), a rare clinical condition occurring in approximately 1 in 18,000 births. Findings from these two chapters converge to show that any relationship between early androgen exposure and subsequent development of autistic traits is small, non-existent, or unreliable, providing a much-needed clarification of the role of early androgen exposure in the aetiology of autism. Using data from a general population study, Chapter 5 (Kung et al., 2018a) is the first study to show that male-typical play behaviour in early childhood, a trait that has been linked to increased early androgen exposure in previous research, can positively predict adolescent physical aggression, which is typically higher in males than in females. This positive association between play and aggression supports potential influences of early androgen exposure, as well as socio-cognitive influences involved in gender development. Chapter 6 (Kung et al., 2018b) is the first study to compare emotional and behavioural adjustment in children with CAH, their unaffected siblings, and children in the general population. Findings from this chapter suggest that although within the families with a child with CAH there are generally no differences in emotional or behavioural problems between boys or girls with CAH and their unaffected same-sex siblings, both girls with CAH and their unaffected sisters are at risk of developing behavioural problems when compared with girls in the general population. Familial influences and social stigma may contribute to this gender-specific pattern of behavioural adjustment. Finally, Chapter 7 (Discussion) integrates the findings and previous research and provides directions for further research. Chapter References Chapter 2 Kung, K. T. F., Browne, W. V., Constantinescu, M., Noorderhaven, R. M., and Hines, M. (2016). Early Postnatal Testosterone Predicts Sex-Related Differences in Early Expressive Vocabulary. Psychoneuroendocrinology, 68, 111-116. Chapter 3 Kung, K. T. F., Constantinescu, M., Browne W. V., Noorderhaven, R. M., and Hines, M. (2016). No Relationship Between Early Postnatal Testosterone and Autistic Traits in 18 to 30-Month-Old Children. Molecular Autism, 7:15. Chapter 4 Kung, K. T. F., Spencer, D., Pasterski, V., Neufeld, S., Glover, V., O'Connor, T. G., Hindmarsh, P. C., Hughes, I. A., Acerini, C. L., and Hines, M. (2016). No Relationship Between Prenatal Androgen Exposure and Autistic Traits: Convergent Evidence from Studies of Children with Congenital Adrenal Hyperplasia and of Amniotic Testosterone Concentrations in Typically-Developing Children. Journal of Child Psychology and Psychiatry, 57, 1455-1462. Chapter 5 Kung, K. T. F., Li, G., Golding, J., and Hines, M. (2018). Preschool Gender-Typed Play Behavior at Age 3.5 Years Predicts Physical Aggression at Age 13 Years. Archives of Sexual Behavior, 47, 905-914. Chapter 6 Kung, K. T. F., Spencer, D., Pasterski, V., Hindmarsh, P. C., Neufeld, S. A. S., Hughes, I. A., Acerini, C. L., and Hines, M. (2018). Emotional and Behavioral Adjustment in 4- to 11-Year-Old Boys and Girls with Classic Congenital Adrenal Hyperplasia and Unaffected Siblings. Psychoneuroendocrinology. 97, 104-110.

O decanoato de nandrolona é um esteróide anabólico-androgênico (EAA), derivado da testosterona, utilizado de maneira abusiva por indivíduos procurando ganho de força física ou apenas efeitos estéticos. Doses suprafisiológicas desses compostos têm sido associadas a efeitos psiquiátricos adversos, especialmente episódios de impulsividade e aumento no comportamento agressivo. Considerando o desconhecimento dos mecanismos neurais envolvidos nessa desinibição comportamental, nós investigamos a integridade da transcrição de componentes do sistema serotoninérgico (intimamente relacionados à expressão de comportamentos emocionais) em diversas áreas cerebrais de camundongos sob a administração prolongada de nandrolona. Camundongos machos adultos da linhagem C57Bl/6J receberam uma injeção subcutânea diária de 15 mg/kg de decanoato de nandrolona durante 28 dias. Diferentes grupos de animais foram utilizados para a análise de comportamentos emocionais e para a quantificação da expressão de genes relacionados à serotonina (5-HT), utilizando a transcrição reversa do RNA associada à técnica de PCR em tempo-real. Os camundongos tratados apresentaram um aumento na massa corporal, hiperatividade motora e aumento de comportamentos relacionados à ansiedade em ambientes novos. A imobilidade avaliada no teste de nado forçado apresentou-se reduzida. Os animais que receberam a nandrolona se mostraram mais agressivos e impulsivos para iniciar o ataque aos camundongos oponentes, no modelo de residenteintruso. O EAA induziu uma redução significante na quantidade de transcritos da maioria dos receptores pós-sinápticos de 5-HT investigados na amígdala e no córtex pré-frontal. A expressão do gene do receptor 5-HT1B (reconhecidamente envolvido com as alterações comportamentais observadas) estava também reduzida no hipocampo e hipotálamo. No mesencéfalo, região onde se encontram os corpos neuronais dos neurônios serotoninérgicos que inervam o sistema límbico e demais áreas cerebrais, não se observou nenhuma alteração na expressão dos genes relacionados aos receptores serotoninérgicos pré-sinápticos. Os transcritos do transportador e da enzima de síntese de 5-HT, indicadores da integridade serotoninérgica pré-sináptica, também não se apresentaram alterados. Dessa maneira, concluímos que o efeito de altas doses do EAA decanoato de nandrolona em camundongos confirma os dados encontrados em literatura quanto à desinibição comportamental observada em usuários abusivos humanos. Nosso modelo também foi eficiente em mostrar pela primeira vez alterações moleculares induzidas por este EAA. A redução generalizada na expressão dos genes de receptores de 5-HT na amígdala e córtex pré-frontal sugere essas áreas, pós-sinápticas ao sistema serotoninérgico, como críticas nos efeitos induzidos pelo EAA. Nosso trabalho também sugere um papel importante para o receptor 5-HT1B na desinibição comportamental observada / Nandrolone decanoate is a highly abused anabolic-androgenic steroid (AAS) by individuals looking for gains in physical strength or body appearance. Supraphysiological doses of this testosterone synthetic derivative have been associated with many physical and psychiatric adverse effects, especially reported episodes of impulsiveness and overt aggressive behavior. Since the neural mechanisms underlying AAS-induced behavioral disinhibition are unknown, we investigated the integrity of serotonergic system transcription in several brain areas of mice under prolonged nandrolone administration. Male C57Bl/6J mice received 15 mg/kg of nandrolone decanoate subcutaneously once daily for 28 days, and different sets of animals were used to investigate motor and emotion-related behaviors or 5-HT-related gene expression by qRT-PCR. AAS-injected mice had increased body weight, were hyperactive and displayed more anxious-like behaviors in novel environments. They exhibited reduced immobility in the forced swim test, higher probability of being aggressive and elevated impulsivity to attack the opponent. AAS induced substantial reduction in the transcription of most postsynaptic 5-HT receptors investigated in the amygdala and prefrontal cortex. Interestingly, 5-HT1B mRNA was further reduced in the hippocampus and hypothalamus. At the midbrain level, there was no alteration in 5- HT receptors, transporter or synthetic enzyme gene transcription. In conclusion, high doses of AAS nandrolone in male mice recapitulate the behavioral disinhibition observed in abusers. Furthermore, they are associated with overall decrease in 5-HT receptor gene expression in the amygdala and prefrontal cortex, implicating these areas as critical sites for AASinduced effects and indicating a role for the 5-HT1B receptor in this behavioral disinhibition

The current study investigated how three distinct types of childhood abuse—witnessing of parental domestic violence, experiencing physical abuse and total in-home violence, and experiencing sexual abuse—predicted partner reports of relational violence through the mediating factors self-perceptions of attachment and partner reports of relational aggression. The study used paired dyadic data from 1,658 couples who had completed the RELATionship Evaluation (RELATE). The Family Violence, the Brief Accessibility and Responsiveness, Couples Relational Aggression and Victimization, and the Conflict Tactics scales were the measures used. Data was analyzed by using structural equation modeling to estimate an actor-partner interdependence model exploring these relationships. Results showed only female childhood sexual abuse had direct associations with male relational violence; however, several mediating paths were identified.

The purpose of this study was to investigate the relationship between relational aggression and sexual satisfaction, as well as the mediating role of attachment on this relationship. Data came from the Relationship Evaluation Survey (RELATE) comprised of the matched-pair responses of 797 couples in serious dating, engaged, or married relationships. Results showed the greater the perceived relational aggression the lower the sexual satisfaction for both self and partner, regardless of gender. Additionally, it appears a more satisfying sexual relationship can occur when an individual experiences a secure attachment base and can feel confident that his/her relationship is safe. For both genders, the more relationally aggressive behaviors reported, the lower the reports of secure attachment behaviors. Implications for clinicians and future research are discussed.

There are studies that found parental psychological control was related to children’s antisocial behavior (e.g., Kuppens, Grietens, Onghena, & Michiels, 2009; Soenes, Vansteenkiste, Goossens, Duriez, & Niemiec, 2008) and other psychological outcomes such as self-esteem and depressive symptoms (e.g., Costa, Soenens, Gugliandolo, Cuzzocrea, & Larcan, 2015; Inguglia et al., 2016; Kline, Killoren, & Alfaro, 2016); however, it is hard to find studies examining how all those variables are dynamically related. The current study aims to examine if parental psychological control during adolescence is related to children’ antisocial behaviors (e.g., social/relational aggression) during college as well as if this association is mediated by children’s social self-esteem and/or depressive symptoms. In addition to examining the dynamic among these variables, the current study is expected to contribute by examining the role of paternal psychological control as well as maternal psychological control. The majority of studies of parental psychological control and children’s outcomes only focus on maternal psychological control findings (e.g., Valdes, Laursen, guimond, Harti, & Denner, 2016). Also, the current study would fill the gap in the existing studies in the matter of ages of children. A number of studies of parental psychological control have mainly been conducted with relatively younger aged children; very few studies examine the development of college students related to parental psychological control (e.g., Kline, Killoren, & Alfaro, 2016). Methods & Results Four hundred two undergraduate college students in the south of the U.S. participated in the current study by completing a survey (female = 51% and male = 49%). They are mainly White (80.3%) and 91 percent were between 19 and 25 years of age (M = 22.01 years; SD = .2.65). Parental Psychological Control during Adolescence was created by calculating the mean of a total of 21 items (α = .95 for maternal/α = .91 for paternal). The example questions are “In general, my mother/father was less friendly with me, if I did not see things her way.” College Students’ Social Self-Esteem was measured with 8 items (α = .82). The example questions are: “I am easy to like.” College Students’ Depressive Symptoms were measured by calculating the mean of a total 20 items (α = .93). The example questions are: In the past week….“I could not shake off the blues.” Relationally/Socially Aggressive Behaviors were measured by 10 items (α = .79), such as “When I am frustrated with my partner/colleague/friend, I give that person the silent treatment.” Structural Equation Model was used to examine the mediation of social esteem and depressive symptoms between parental psychological control and children’s social/relational aggressive behaviors (see the Table 1 for descriptive statistics of the variables). As seen in Figure 1, there were indirect significant positive associations between maternal psychological control and antisocial behaviors via depressive symptoms; however, paternal psychological control was directly positively associated with antisocial behaviors as well as indirectly associated with antisocial behaviors via social esteem. More findings, interpretations, and limitations of the current study will be discussed at the conference.

This longitudinal study examined the relationship between husband and wife shame and husband and wife sexual satisfaction one year later with husband and wife relational aggression as mediating variables. The sample included 353 heterosexual married couples who participated in the Flourishing Families Research Project, a longitudinal study of daily family life. Results showed that husband and wife shame was negatively related with husband and wife sexual satisfaction, respectively. Husband love withdrawal was negatively related with both husband and wife sexual satisfaction, while wife love withdrawal was negatively related with only husband sexual satisfaction. Each partner's use of social sabotage was negatively related with their partner's sexual satisfaction. Research and clinical implications were discussed.

Partant d’une pratique clinique en milieu pénitentiaire, nous nous sommes rendus compte de l’importance de la violence tant de celle contenue dans les motifs d’incarcération que celle amenée comme une énigme silencieuse dans les problématiques subjectives pouvant se faire entendre à la faveur des entretiens à visée thérapeutique que nous avons avec les personnes incarcérées.Au moyen d’outils prélevés dans des champs de recherche se référant à la méthode expérimentale, nous avons procédé à des observations et les avons traduites au moyen de traitements statistiques pour en tirer des conclusions faisant écho aux hypothèses formulées en amont. Cette approche a été confrontée à celle de la clinique en psychologie en prenant appui sur l’analyse et la construction de cas. Des cas et vignettes ont été exposés dans le but d’en prélever la part transversale ou généralisable d’un fonds singulier.Cette méthodologie comparative est utilisée comme une opportunité pour nous permettre d’interroger le choix épistémologique parfois implicite auquel nous nous sommes référés. Ce détour s’est présenté comme une nécessité didactique, propice, à consolider notre désir de savoir et, à être soumis à un examen critique.Ce parcours heuristique nous a permis de mettre à l’étude les énigmes toujours particulières que nous lègue chaque patient et parmi elles, des blessures anciennes et silencieuses qui accompagnent un malaise postcolonial dont l’un des modes prévalents d’expression sans parole est l’agir violent. Ce qui ne fait pas équivaloir l’agir violent à une maladie mais à une rupture en quête de sens ou encore à une manifestation d’un défaut de sens.Le travail thérapeutique avec les personnes détenues reçues comme patients montre que le traitement par la parole peut être une opportunité pour initier une autre forme d’élaboration subjective par le truchement d’un moment de reconnaissance. / Initiating from a clinical practice at a penitentiary, we realized the importance of violence both on grounds for incarceration and presented as a silent enigma in the subjective problems that can be heard through therapeutic interviews that we have with prisoners.Using tools taken from research fields based on the experimental method, observations were made and translated using statistical methods to draw conclusions in relation with the hypothesis formulated beforehand.This approach was compared with that of clinical psychology supported by analysis and case construction. Cases and thumbnails have been exhibited in order to extract the common factor of a singular framework.This comparative methodology’s purpose allow us to interrogate the sometimes implicit epistemological choice by which we are driven. This detour presented itself as a didactic necessity, conducive at consolidating our desire to know and to be subjected to a critical examination.This heuristic path allowed us to study the ever-present enigmas left to us by each patient and among them the old and silent wounds that accompany postcolonial discomfort, one of the prevalent modes of speechless expression is act violently. This does not equate violent action as a disease but as a fracture in the search for meaning or as a demonstration of a deficience of meaning.The therapy sessions of the detainees received as patients shows that treatment via speech can be an opportunity to initiate another form of subjective elaboration through a moment of recognition.

For a while, video games have been the target of scrutiny with regards to their perceived potential to adversely affect younger individuals. In particular, it is often argued that these video games, particularly those of violent nature, may increase hostility to an extent that it manifests itself in violent behavior. This thesis aims to denote what effects these video games have on young adults, particularly in relation to the respondents’ indicated extent of adverse childhood experiences, trait anger, and competitiveness, all three of which were assumed to have a positive relationship with hostility. A survey was distributed to students attending Western Kentucky University in an attempt to measure what effects these three aforementioned variables have on young adults, in addition to what affects video game playing and violence in video games may have on hostility and aggression. From the data acquired, it was clear that while adverse childhood experiences had no statistical significance in this study and higher competitiveness indicated a very slight decline in hostility, trait anger did in fact appear to raise hostility in the respondents. Additionally, increases in exposure to both video game play and violence in video games were shown to lead to a decrease in hostility. From this, it would appear that trait anger was the only variable to truly increase hostility in young adults, and the often-discussed variables of video game play and violence in video games both appear to decrease hostility in respondents as exposure to either factor increases, thus going against the common assumptions.

The current study examines associations between community violence exposure (CVE) and internalizing and externalizing symptoms. The emotional desensitization hypothesis states that moderate levels of CVE will be associated with increased internalizing symptoms, whereas high levels of CVE will be associated with decreases in internalizing distress. The current study extends prior research by examining whether patterns of emotional desensitization differ based on the route of exposure – either being personally victimized or witnessing community violence. Further, associations examined the influence of interpersonal proximity to the victims of violence – that is, whether individuals are victims themselves (most proximal), witness violence against known individuals, or witness violence against strangers (least proximal). Participants include 714 undergraduate students (Mage = 20.5 years, SD = 3.9) who completed an online survey of CVE, internalizing and externalizing outcomes, and cognitions supporting aggression. Results revealed significant moderation by interpersonal proximity. Specifically, curvilinear associations between CVE and internalizing symptoms, reflecting emotional desensitization, were stronger at lower levels of proximity, whereas positive linear associations emerged at higher levels of proximity. Associations between CVE and more externalizing behaviors were stronger at low, compared to high, levels of proximity. Internalizing symptoms and cognitions supporting aggression partially mediated the association between CVE and externalizing behaviors. Further, latent profile analysis revealed that distinct groups of individuals were classified based on cumulative frequency of CVE and types of violent experiences. Thus, route of exposure, relationship to the victims of violence, and type of violence are each salient characteristics of CVE that may relate differentially to adjustment.

There is convincing support for the link between family composition and adolescents’ problem behaviors. What is less clear is the extent to which these relations exist for African-American adolescents. Previous studies have demonstrated that this relation varies by gender. However, there is limited evidence to suggest the potential moderating influence of adult support. The purpose of this study was to examine the influence of family composition on adolescents’ physical aggression, delinquency, and substance use. The study comes from secondary analyses of a larger study that evaluated the effectiveness of a violence prevention program. The current study included 1,116 African-American middle school students from an urban setting who endorsed living with their biological mother and considered her to be their parent. Results indicated that among adolescents who identified their nonresidential biological father as their parent, those in stepfather families reported lower levels of delinquency than those in single-mother families. Support was not found for similar differences in self-report of delinquency and substance use, and teacher-report of adolescents’ physical aggression. No other differences in family composition were found for adolescent problem behavior. Support was also not found for the moderating roles of gender or adult support. However, self-report of delinquency and substance use, and teacher-report of physical aggression were negatively related to adult support. This was not the case for self-report of physical aggression. These findings suggest that interventions may need to provide additional resources that would help both parents and adolescents within single-parent families.