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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Phosphorylierung des Angiotensin konvertierenden Enzyms Identifikation und funktionelle Bedeutung /

Kohlstedt, Karin Herta. January 2002 (has links)
Frankfurt (Main), Univ., Diss., 2002.

Angiotensin-converting enzyme inhibitors in heart failure clinical end points to assess therapeutic efficacy /

Broek, Stanislaus Antonius Jacobus van den. January 1994 (has links)
Proefschrift Rijksuniversiteit Groningen. / Auteursnaam op omslag: Stan A.J. van den Broek.

A Comprehensive Study of Phenolics and Peptides from Three Legume Varieties

Zhang, Yan 06 May 2017 (has links)
Lentil, black soybean and black turtle have been proved to be phenolic-rich legume varieties and possess higher antioxidant activity. In this study, the three legume varieties were subjected to broad range of processing conditions, and the effects on phenolic contents, antioxidant capacity and individual phenolic acid were investigated. The results showed all processing methods could decrease the total phenolic content, and steaming processing could preserve more phenolics and antioxidant activity than boiling processing. Phenolic acids mainly existed in nonree form and the content of individual free phenolic acids was dependent on the thermal process applied. When in vitro gastrointestinal simulation digestion was applied to the thermally processed beans, it was found that the properties of hydrolysates including total phenolic content, antioxidant activity, degree of hydrolysis, and ACE (angiotensin converting enzyme) inhibitory activity were all affected by thermal conditions employed. There was a weak correlation between the degree of hydrolysis and ACE inhibition. In the current study, for each legume variety, cooking conditions which yielded the highest phenolic content and antioxidant activity were selected. Phenolics of the raw and cooked seeds from each legume variety were extracted, semi-purified (XAD-7) and further fractionated (Sephadex LH-20). The results showed cooking had great effects on yield, phenolic content, antioxidant capacity, and individual phenolic compounds. The phenolic content and antioxidant activity could be enriched tremendously in the semi-purified extracts and some fractions. Some phenolic compounds which were absent in raw material could be found after cooking in the fractions and some phenolic compounds which were present in raw material disappeared after cooking. Among crude phenolic extracts, semi-purified extracts and fractions, only crude extracts showed ACE inhibition. In addition, protein isolates from the legumes varieties were treated with in vitro GI (gastrointestinal) digestion and then separated by ultrafiltration, DEAE anion exchange chromatography and gel permeation chromatography. After ultrafiltration, the lowest molecular weight fraction (< 3kD) had the highest ACE inhibition and the three legume varieties showed different peptide distribution, ACE inhibition, and antioxidant profile in the hydrolysates. Gel filtration chromatography further revealed that the most potent ACE inhibitors were peptides of 2-5 amino acids long.

Towards an integrated approach on RAAS-blockade

Lely, Anna Titia, January 2007 (has links)
Proefschr. Rijksuniversiteit Groningen. / Met lit. opg.-Met samenvatting in het Nederlands.

Angiotensin-Converting-Enzyme (CD143) in der Tumorpathologie von Mensch und Tier : immunhistochemischer Beitrag zur Expression von ACE in Tumoren und ihrer Vaskularisation /

Kerkman, Luke. January 2001 (has links)
Universiẗat, Diss., 2000--Giessen.

Ace inhibitors and cardiovascular regulation the importance of autocrine and paracrine mechanisms /

Wijngaarden, Jan van. January 1992 (has links)
Proefschrift Rijksuniversiteit Groningen. / Met lit.opg. - Met samenvatting in het Nederlands.

Rational design and delivery of peptide drugs

Gupta, Sona January 2000 (has links)
No description available.

Mechanisms underlying the inotropic response to angiotensin II in the heart

Mielke, Marilyn January 1999 (has links)
No description available.

Mentally Ill Caregivers And Differential Patterns of Substance Abuse in a Sample of University Students

Cobb, Teliyah, Gretak, Alyssa P, Puszkiewicz, Kelcey L, Stinson, JIll D, Quinn, Megan 05 April 2018 (has links)
MENTALLY ILL CAREGIVERS AND DIFFERENTIAL PATTERNS OF SUBSTANCE ABUSE IN A SAMPLE OF UNIVERSITY STUDENTS Teliyah A. Cobb1, Alyssa P. Gretak1, MA, Kelcey L. Puszkiewicz1, MA, Jill D. Stinson1, PhD, and Megan Quinn2, DrPH, MSc, East Tennessee State University, Johnson City, TN 1Dept. of Psychology, College of Arts and Sciences 2Dept. of Biostatistics and Epidemiology, College of Public Health Existing literature demonstrates a dose-responsive relationship between adverse childhood experiences (i.e., abuse, neglect, and household dysfunction) and the risk of problematic substance use later in life. While controlling for the effects of early adversity, a recent study found that childhood household dysfunction independently increased the risk of excessive alcohol use in adulthood. However, there are few studies focusing specifically on differences in substance use behaviors in individuals who had a caregiver with a mental health diagnosis. This study aims to fill this gap by examining whether having a caregiver with mental illness during one’s childhood increases the risk of abusing alcohol and illegal or prescription drugs in adulthood in a college sample. Our sample includes University students in the Southeastern U.S. (N = 995) who are mostly Caucasian (84%) and female (63%). Participants completed an online, anonymous survey for course credit. Approximately 23% (n = 227) reported having a caregiver with mental illness or who attempted or died by suicide. Regarding substance abuse, nearly 11% of the sample (n = 106) reported abuse of alcohol, 13% (n = 126) indicated abuse of illegal drugs, and almost 5% (n = 47) reported abuse of prescription medication. Pearson Chi-square tests were conducted to analyze the relationship between caregiver mental illness, including a caregiver who attempted or died by suicide, and abuse of alcohol, illegal, and prescription drugs in adulthood. Interestingly, individuals with a mentally ill caregiver were less likely to abuse alcohol, c2 (1, N = 983) = 12.56, p = .000, and illegal drugs, c2 (1, N = 984) = 22.68, p = .000, as an adult, compared to those without a mentally ill caregiver. In contrast, students with a mentally ill caregiver were more likely to abuse prescription drugs as adults, c2 (1, N = 979) = 32.54, p = .000, compared to those without a caregiver suffering from a mental illness. Thus, findings suggest that having a mentally ill caregiver differentially impacted the risk of abusing varying types of substances. Additional analyses examining the influence of mental illness in biological versus non-biological caregivers (e.g., stepparent, foster parent) and further discussion of implications will be included.

Implementation and evaluationof the ACE DTLS framework : Reducing the authentication workload of a constrained device / Implementering och utvärdering av ACE-ramverket

Johansson, Jacob January 2019 (has links)
IoT-devices are becoming more advanced and powerful than ever, and the applicationpotential is increasing rapidly. It is starting to become normal to have IoT-devices takingover mundane jobs such as controlling the climate at home, or monitoring e.g the water us-age of a household. These devices are usually constrained to be as cheap and primitive asthe task allows. Most of the time, they are only used to send collected data which only re-quires a one way secure channel. However, in order to apply updates or manage the deviceremotely, the communication has to be secured both ways. There are multiple suggestionson how a two way secure channel can be established while still operating on a constraineddevice. Each security specializes in its own area e.g privacy, scalability, or simplicity. Thispaper will describe how to implement the ACE-DTLS framework and analyze the perfor-mance with respect to energy consumption and security. While ACE-DTLS is quite simpleto implement without having to understand the complex math of a key exchange, it comeswith the cost of a high overhead in order to establish a secure two way connection. It mightnot be the best suited framework for small amount of data transfers available.

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