This study explores Sibelius's last and, perhaps, most enigmatic Symphony from historical (source-critical), Schenkerian, and transtextual perspectives. Through a detailed study of its genesis, musical architecture, and meaning, the author maintains that the Seventh, its composer, and its generative process, can best be understood as a series of verges: conceptual points of interaction between two or more forces. Verges between Sibelius's nature mysticism and the dramatic biographical circumstances of the period (1914-1924), between inspired and reasoned modes of composition, between genres (symphony and fantasy), between various form types, between tragic despair and hopeful yearning, between innovation and classicism, and between a host of other seeming oppositions, all define the Seventh Symphony and illuminate various facets of the composer's life and thought.

A spectroscopic analysis of 10 intergalactic star-forming objects (ISFOs) and a photometric analysis of 67 ISFOs in a sample of 14 interacting systems is presented. The majority of the ISFOs have relative polycyclic aromatic hydrocarbon (PAH) band strengths similar to those of nearby spiral and starburst galaxies. In contrast to what is observed in blue compact dwarfs (BCDs) and local giant H II regions in the Milky Way (NGC 3603) and the Magellanic Clouds (30 Doradus and N 66), the relative PAH band strengths in ISFOs correspond to models with a significant PAH ion fraction (<50%) and bright emission from large PAHs (∼100 carbon atoms). The [Ne III]/[Ne II] and [S IV]/[S III] line flux ratios indicate moderate levels of excitation with an interstellar radiation field that is harder than the majority of the Spitzer Infrared Nearby Galaxies Survey and starburst galaxies, but softer than BCDs and local giant H II regions. The ISFO neon line flux ratios are consistent with a burst of star formation ∼6 million years ago. Most of the ISFOs have ∼106 M ⊙ of warm H2 with a likely origin in photo-dissociation regions (PDRs). Infrared Array Camera photometry shows the ISFOs to be bright at 8 μm, with one-third having [4.5]-[8.0] > 3.7, i.e., enhanced non-stellar emission, most likely due to PAHs, relative to normal spirals, dwarf irregulars, and BCD galaxies. The relative strength of the 8 μm emission compared to that at 3.6 μm or 24 μm separates ISFOs from dwarf galaxies in Spitzer two-color diagrams. The infrared power in two-thirds of the ISFOs is dominated by emission from grains in a diffuse interstellar medium. One in six ISFOs have significant emission from PDRs, contributing ∼30%-60% of the total power. ISFOs are young knots of intense star formation.

Each year more international students enroll in American universities, and administrators nationwide must determine how to meet students' unique writing needs. Compared to similar institutions of higher learning, Brigham Young University (BYU) has a large percentage of international students—4.3 percent of the student body, approximately 2,000 students each year from 112 countries. Prior to Fall 2004, international students were placed in courses offered through the English composition program, which focuses on "mainstream" college writers who compose in their first language (L1) and not on second language writers and their unique needs. As a result, many international students did poorly and often failed their general education freshman writing requirement. The Department of Linguistics and English Language at BYU offers some English as a Second Language (ESL) courses in an effort to prepare students for freshman writing, but since these courses are electives and do not count towards the university general education requirement, many students opt not to take them. International students need a viable alternative to the "mainstream" freshman writing course. They need a course in academic literacy, combining the rhetorical and composition elements of a freshman writing course as well as the multicultural and applied linguistic elements of writing. The needs of writers need to be discussed and met through a balanced, interdisciplinary approach. Under the direction of the Department of Linguistics and English Language, I developed a course based upon an interdisciplinary approach to second language writing and academic literacy. I researched the needs of second language writing students, evaluated current ESL programs nationwide, created, implemented, and evaluated a curriculum for an international freshman writing course. It is a course in academic literacy, called Elang 105, which was specifically designed to meet the needs of international students and is now one of the general education (GE) first year writing options at BYU.

Micro (mi)RNAs have recently been found to play an important role in cancer biology. In order to further understand how miRNAs affect prostate tumour progression, we evaluated miRNA expression in two invasive prostate tumour lines, PC3 and DU145. We then focused our evaluation on a novel miRNA, miR-105, whose levels were significantly decreased in both tumour cell lines as compared to normal prostate epithelial cells. As miR-105 levels were reduced in prostate tumour cell lines, we restored its expression following transfection of cells with mimic constructs to over-express miR-105 in both cell lines, in order to determine its effect on various tumourigenic properties. Over-expression caused decreased tumour cell proliferation, anchorage-independent growth and invasion in vitro and inhibited tumour growth in vivo. We further identified CDK6 as a putative target of miR-105, which likely contributed to its inhibition of tumour cell growth. Our results suggest that miR-105 inhibits tumour cell proliferation and may be an interesting target to regulate tumour growth or potentially used as a biomarker to differentiate between less and more aggressive tumours in patients.

Micro (mi)RNAs have recently been found to play an important role in cancer biology. In order to further understand how miRNAs affect prostate tumour progression, we evaluated miRNA expression in two invasive prostate tumour lines, PC3 and DU145. We then focused our evaluation on a novel miRNA, miR-105, whose levels were significantly decreased in both tumour cell lines as compared to normal prostate epithelial cells. As miR-105 levels were reduced in prostate tumour cell lines, we restored its expression following transfection of cells with mimic constructs to over-express miR-105 in both cell lines, in order to determine its effect on various tumourigenic properties. Over-expression caused decreased tumour cell proliferation, anchorage-independent growth and invasion in vitro and inhibited tumour growth in vivo. We further identified CDK6 as a putative target of miR-105, which likely contributed to its inhibition of tumour cell growth. Our results suggest that miR-105 inhibits tumour cell proliferation and may be an interesting target to regulate tumour growth or potentially used as a biomarker to differentiate between less and more aggressive tumours in patients.

Micro (mi)RNAs have recently been found to play an important role in cancer biology. In order to further understand how miRNAs affect prostate tumour progression, we evaluated miRNA expression in two invasive prostate tumour lines, PC3 and DU145. We then focused our evaluation on a novel miRNA, miR-105, whose levels were significantly decreased in both tumour cell lines as compared to normal prostate epithelial cells. As miR-105 levels were reduced in prostate tumour cell lines, we restored its expression following transfection of cells with mimic constructs to over-express miR-105 in both cell lines, in order to determine its effect on various tumourigenic properties. Over-expression caused decreased tumour cell proliferation, anchorage-independent growth and invasion in vitro and inhibited tumour growth in vivo. We further identified CDK6 as a putative target of miR-105, which likely contributed to its inhibition of tumour cell growth. Our results suggest that miR-105 inhibits tumour cell proliferation and may be an interesting target to regulate tumour growth or potentially used as a biomarker to differentiate between less and more aggressive tumours in patients.