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Predictors of Muscle Function in Hemodialysis PatientsMahdavi, Sara 15 July 2013 (has links)
Decreased skeletal muscle function (MF) is ubiquitous in hemodialysis (HD) patients and linked to functional decline. Serum vitamin D (25-OHD) and habitual physical activity (PA) are decreased in HD and linked to reduced MF in other populations. The associations between 25-OHD, PA, and MF were investigated in 81 stable HD patients. PA intensity was quantified using accelerometery, MF using handgrip strength dynamometery, 25-OHD via serum measures, and dietary and supplementation of vitamin D intake via three-day food records. MF correlated with PA (r =0.411, p = 0.003) when controlled for body mass (BM) and with 25-OHD (r =0.298, p = 0.023) when controlled for BM, age, and sex. Both MF (r=0.285, p=0.025) and 25-OHD (r=0.314, p=0.005) correlated with vitamin D supplementation. MF remained correlated with supplementation after controlling for 25-OHD (r=0.269, p=0.037). These findings should be further explored in interventional studies to assess how their manipulation influences MF in HD.
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Predictors of Muscle Function in Hemodialysis PatientsMahdavi, Sara 15 July 2013 (has links)
Decreased skeletal muscle function (MF) is ubiquitous in hemodialysis (HD) patients and linked to functional decline. Serum vitamin D (25-OHD) and habitual physical activity (PA) are decreased in HD and linked to reduced MF in other populations. The associations between 25-OHD, PA, and MF were investigated in 81 stable HD patients. PA intensity was quantified using accelerometery, MF using handgrip strength dynamometery, 25-OHD via serum measures, and dietary and supplementation of vitamin D intake via three-day food records. MF correlated with PA (r =0.411, p = 0.003) when controlled for body mass (BM) and with 25-OHD (r =0.298, p = 0.023) when controlled for BM, age, and sex. Both MF (r=0.285, p=0.025) and 25-OHD (r=0.314, p=0.005) correlated with vitamin D supplementation. MF remained correlated with supplementation after controlling for 25-OHD (r=0.269, p=0.037). These findings should be further explored in interventional studies to assess how their manipulation influences MF in HD.
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