Higher speeds and higher capacity will cause the Swedish rail network to be exposed to disturbing dynamic effects. Higher speeds cause higher vertical acceleration levels of the bridge deck. In this thesis, a numerical analysis of a three span end-frame bridge subjected to train induced vibrations is performed. The aim is to identify which structural components and boundary conditions that affect the dynamic behavior of the bridge. Furthermore, the influence of soil structure interaction (SSI) will be investigated as it may have contribution to the stiffness and damping of the structural system.  In order to capture the dynamic response of the bridge, an analysis in the frequency domain was preformed where frequency response functions (FRF) and acceleration envelopes were obtained. For this purpose, a detailed FE-model in 3D was created. Three different cases were studied, model subjected to ballast, model subjected to soil and model subjected to both ballast and soil in coherence. A high speed load model (HSLM) was used to create simulation of train passages at different speeds and applied to all cases so that the bridge deck accelerations could be studied. A simplified 2D-model with impedance functions representing the soil-structure interaction was created to validate the results from the detailed 3D-model and for practical design purposes.  The result of this numerical analysis showed that the vertical accelerations were within acceptable levels of the maximum allowed limits given in governing publications. Considering the surrounding soil, the results revealed an increase of the dynamic response in the midspan at resonant frequency. However, it was identified that this behavior is not explained by the influence of soil structure interaction but rather the change in boundary conditions of the end-shields. The same dynamic behavior was identified for the simplified 2D-model, with a slight underestimation of the vertical accelerations at resonance.