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La presencia de residuos de sustancias antimicrobianas en la leche supone un riesgo toxicológico para la salud pública así como un problema tecnológico para la industria láctea. La información disponible sobre la termoestabilidad de los antimicrobianos en la leche a las diferentes temperaturas empleadas a lo largo de la cadena de producción, es hasta el momento muy limitada. Por ello se planteó la realización de este trabajo donde se ha evaluado la influencia de las condiciones de almacenamiento de la leche sobre algunos antimicrobianos pertenecientes a los antibióticos betalactámicos, tetraciclinas y sulfonamidas así como el efecto del calentamiento de la leche a distintas temperaturas sobre la estabilidad de estas sustancias. El estudio de la influencia de la refrigeración (4 ± 2 ºC) y congelación (-20 ± 2 ºC) se realizó sobre muestras de leche enriquecidas con 20 sustancias antimicrobianas a unas concentraciones equivalentes a los Límites Máximos de Residuos (LMR), así como de sus correspondientes extractos obtenidos previo al análisis cromatográfico y las determinaciones se realizaron a diferentes tiempos de almacenamiento mediante un equipo HPLC-MS/MS. Los resultados obtenidos indican que la refrigeración y la congelación de la leche afectan en mayor medida a los antibióticos betalactámicos que a las tetraciclinas, tanto en los extractos como en las propias muestras, y no presentan ningún efecto sobre la estabilidad de las sulfonamidas. También se observa como en los extractos las pérdidas son, en general, menores que en las muestras de leche y que la congelación mejora también, en la mayoría de los casos, la estabilidad de las sustancias antimicrobianas en comparación con la refrigeración. Se recomienda por lo tanto conservar tanto las muestras de leche como los extractos en refrigeración y congelación el mínimo tiempo posible para intentar reducir la variabilidad entre resultados analíticos realizados en una misma muestra de leche en diferentes etapas de cont / Roca Marugán, MI. (2008). Termoestabilidad de sustancias antimicrobianas en la leche [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/3022

Polynesian architecture has tended to be neglected or dismissed as a field of serious study by architects in New Zealand. This is also true of the indigenous art forms in general, which have been the source of substantial scholarship by ethnologists; scholarship of which art specialists, are often unaware. The result is that apart from monographs with an ethnological viewpoint, the treatment of indigenous architecture has been superficial at best.

Polynesian architecture has tended to be neglected or dismissed as a field of serious study by architects in New Zealand. This is also true of the indigenous art forms in general, which have been the source of substantial scholarship by ethnologists; scholarship of which art specialists, are often unaware. The result is that apart from monographs with an ethnological viewpoint, the treatment of indigenous architecture has been superficial at best.

Drainage codes exist to provide appropriate and safe means of disposal of effluent from buildings. If it is seen that those codes may not be written in a way which leads to an assured appropriate outcome, then they need to be questioned. Accordingly, this thesis follows up on the author's concerns regarding the approach taken to the layout of drainage under today's building regulatory regime. Under the New Zealand Building Code any standards may be used or any approach may be taken to methods of building, drainage and plumbing, providing the approach used can be justified as complying with the non-prescriptive objectives and performance requirements of the Building Code. Under this approach drains are now being installed more often under buildings with their maintenance access points within the building. This situation, and the consequent likely emission of microbiological aerosols, are cause for concern: that is the airborne release of microscopic particles. The "Report of the Departmental Committee - Intercepting Traps in House Drains" of 1912 from the UK, parts of which are quoted in Section 7.0, reinforced these concerns of the author. But these concerns were not shared by many others who have a major influence on the form and shape of our buildings, and it was assumed that current code requirements may not have been based on any significant research. Based on a relatively widespread lack of knowledge, there was a scenario of doubt and denial as to whether or not there were shortcomings in current code requirements in New Zealand. This provided incentive for the research project within this thesis, on the basis that there may be encouragement for future code requirements to be based on even more research in order to confirm their validity. This thesis demonstrates that the ambiguity in existing approved methods of compliance with current building codes fails to adequately protect the populace from adverse potential health effects. / Whole document restricted, but available by request, use the feedback form to request access.

Polynesian architecture has tended to be neglected or dismissed as a field of serious study by architects in New Zealand. This is also true of the indigenous art forms in general, which have been the source of substantial scholarship by ethnologists; scholarship of which art specialists, are often unaware. The result is that apart from monographs with an ethnological viewpoint, the treatment of indigenous architecture has been superficial at best.