Substance abuse is a significant challenge facing the World and in particular South Africa. In this study, various Western and African traditional perspectives were considered to gain an understanding of the substance abuse problem among adolescents. The study was conducted in one of the rural villages of the Ramotshere Moiloa Local Municipality in the North West Province of South Africa. Participants included 24 African male and female adolescents between 13 and 19 years of age, as well as 2 parents and 9 professionals. The 9 professionals are educators, a social worker, a clinical psychologist, a mental health worker, a traditional leader and a traditional healer, between 37 to 53 years of age. A qualitative, explorative research design was employed. Data sources included individual face-to-face interviews, focus group discussions, and a document review. Thematic analysis was employed to analyse data. The findings were based on the perceptions of participants and revealed that adolescents are socially entrapped to substances such as alcohol, tobacco, cannabis, cocaine, glue, nyaope, and segonyamahlo. Reasons for their use of substances included individual, family, and environmental factors. The findings revealed the severe impact of substance abuse on adolescents and their families. There was evidence of primary, secondary, and tertiary levels of substance abuse prevention programmes targeting adolescents and other community members. In addition, stakeholders such as parents, peers, professionals, traditional leaders, traditional healers, government, and non-government organisations were recommended to implement substance abuse prevention programmes to address the substance abuse problem among adolescents. Furthermore, the study highlighted efforts made to reflect on the implemented substance abuse prevention programmes. / Psychology / D. Phil. (Psychology)