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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Damage to DNA induced by low energy electrons and photons : mechanisms and analysis at the molecular level

Śmiałek, Małgorzata January 2007 (has links)
No description available.

Investigation of the biological effects of radiofrequency radiation using the nematode caenorhabditis elegans

Dawe, Adam Sean January 2004 (has links)
No description available.

Biophysical interaction of nanoparticles and radiation

Elsaesser, Andreas Karl Gerhard January 2011 (has links)
Whilst nanotechnology and the use of nanomaterials in research and industry are growing rapidly, the understanding of interactions between nanomaterials and biological systems is still in its infancy. Nanomaterials of high interest to scientists are nanoparticles due to their high surface-to-volume ratio and hence increased surface reactivity. When in contact with biological matter, nanoparticles are ingested by cells and tissue, accumulate and travel within the living system. This is why nanoparticles not only attract great interest in medicine but also create great concern amongst toxicologists. The in vitro and in vivo mechanisms and pathways of nanoparticles are subject to intense research and exposure to nanoparticles may pose a serious public health risk. Although radiophysical and radiobiological effects of ionising radiation are well understood, research into interactions between electromagnetic radiation and nanoparticles has been sparse. Whilst medicine articulates strong interests in nanoparticles as radiosensitisers, understanding biophysical interactions of nanoparticles and radiation still demands further research. This thesis aims to address fundamental interaction mechanisms between nanoparticles and radiation and to establish the biological impact of photoelectron production as a consequence of nanoparticle irradiation. Our data confirms that X-ray irradiation of gold nanoparticles produces secondary electrons. However, secondary electron production had no perceptible biological effects in terms of cell survival or DNA damage. The absence of DNA damage can be explained by the fact that nanoparticles accumulate in lysosomal compartments and electrons generated there are unable to reach the nuclear target. Free electron production entails the generation of reactive oxygen species, a key component when assessing nanoparticle toxicity. This study confirms that an increase in reactive oxygen species due to nanoparticle irradiation is particle size dependent and detectable at the chemical level. However, in vitro experiments show that such an increase in reactive oxygen species due to particle size is irrelevant. This is likely to be caused by nanoparticle agglomeration in cytoplasmic vesicles. The agglomerated particles act as a cluster rather than individual particles leading to increased reabsorption of secondary electrons by nearby particles. In conclusion, this work confirms the size and energy dependent production of secondary electrons by nanoparticles at the physical and chemical level. In a biological context, however, and with the parameters used in this study, secondary electron production seems to play a minor role with little impact for therapeutic applications or potential carcinogenic effects of background radiation.

Laser driven acceleration of ions and its application in radiobiology

Kakolee, Kaniz Fatema January 2012 (has links)
No description available.

The feasibility and toxicity of direct intratumoral injections of yttrium-90 ('9'0Y) radioimmunoconjugates in the treatment of patients with malignant gliomas

Hopkins, K. January 1996 (has links)
No description available.

Measurements of the complex permittivity of dielectric reference liquids and human tissues

Jenkins, Sharon January 1991 (has links)
No description available.

The relationship between cellular radiation sensitivity and normal tissue response to radiotherapy : prospects for individualising radiotherapy prescriptions

Burnet, Neil Gunn January 1993 (has links)
No description available.

A scattering method for bone density measurements with polychromatic sources

Koligliatis, Thanos January 1990 (has links)
No description available.

Experimental techniques to characterise localisation in nuclear magnetic resonance spectroscopy

Keevil, Stephen Frederick January 1996 (has links)
No description available.

Effects of radiation on the structure and vasculature of the small intestinal villus

Abbas, Babar January 1990 (has links)
No description available.

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