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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 1 to 10 of 32 (0.007 seconds)| 1 |
Expression, localisation and function of Rab27 proteinsBarral, Duarte Custal Ferreira January 2003 (has links)
No description available.
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Chromatin remodelling in T cell tuningGuyver, Carly Jane January 2007 (has links)
No description available.
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The role of Fyn in regulating T cell responsesFilby, Andrew John January 2005 (has links)
We have addressed the role of Fyn in T cells using two different transgenic mouse systems. Using the class I-restricted F5 TCR transgenic model, we found that Fyn CD8 cells showed normal triggering and entry into cell division over a range of peptide concentrations, but subsequently proliferated more than WT CD8 cells. Increased proliferation of F5 Fyn cells was driven by their ability to produce more IL-2, which occurred only after cross-linking TCR and CD8 molecules with antibodies or pMHC, not by triggering through the TCR alone. Additionally, F5 Fyn cells showed differences in the induction of specific AP I members that could influence IL-2 production. F5 Fyn7 cells required only 1 hr stimulation with Ag to commit to IL-2 production, whereas F5 WT cells needed -5 hrs, and yet IL-2 production by Fyn cells remained sensitive to the Src-inhibitor PP2, added after 3 hrs. These data suggest that loss of Fyn uncouples Lck activity from the need for sustained exposure to antigen and therefore, that Fyn acts as a negative regulator to limit IL-2 production in CD8 T cells. Not only was proliferation of F5 Fyn7 cells increased compared to WT controls, but so was the CTL response as judged by effector molecule expression and also specific killing activity. Like the increase in proliferation, the improved generation/function of Fyn7 CTL compared to WT was dependent on the levels of IL-2 produced by these cells. In our second transgenic model, Fyn7 mice expressing reduced amounts of Lck were generated. These animals develop a fatal lymphoproliferative disorder, characterized by gut pathology and weight loss, an expansion of effector-memory like CD4*CD44" cells, and the appearance of anti-nuclear antibodies (ANA). Disease was ameliorated by turning off Lck expression, suggesting that an appropriate balance of Lck and Fyn activity is required in vivo to achieve cell survival without stimulating autoimmunity. Our data provides functional in vivo and in vitro evidence for a regulatory role for Fyn in both CD4 and CD8 T cells.
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Physiology of anergic CD8 T cells in a transgenic mouse modelStamou, Panagiota January 2003 (has links)
No description available.
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Cellular and molecular characterisation of HIV-resistance mechanisms in CD4 T cellsKing, Deborah Frances Louise January 2005 (has links)
No description available.
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Dynamics of the T-cell response to HTLV-IMosley, Angelina Jane January 2004 (has links)
No description available.
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Functional and molecular characterisation of CD4(204)CD25(204) regulatory T cellsRobertson, Nathan Jones January 2004 (has links)
No description available.
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Involvement of centromeric localisation of genes in murine T cell lineage commitment and allelic exclusionRoldaÌn, Esther January 2003 (has links)
No description available.
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Protein interactions mediated by CD86 and related molecules of the immune systemTurner, Alison Victoria January 2006 (has links)
No description available.
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The nature of gamma-delta T cell / macrophage interactions in a pathogen induced immune responseDalton, Jane E. January 2004 (has links)
No description available.
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